GREMLIN Database
PGG - Domain of unknown function
PFAM: PF13962 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (112)
Sequences: 3181 (1924)
Seq/√Len: 181.8
META: 0.075

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_S107_V3.7511.00
6_K9_N3.3391.00
32_G42_G2.6431.00
11_L74_L2.4931.00
60_N113_S2.3421.00
55_V111_A2.3251.00
25_A56_F2.2431.00
36_D39_H2.2151.00
15_A71_I2.1841.00
37_D40_D2.0561.00
12_L16_T1.9961.00
57_F113_S1.8581.00
34_W39_H1.8411.00
83_F87_L1.8091.00
32_G46_L1.7951.00
36_D40_D1.7031.00
31_G42_G1.6551.00
62_I100_L1.6541.00
27_F60_N1.6281.00
13_V16_T1.6151.00
18_I105_M1.5591.00
26_G60_N1.5401.00
22_T63_A1.5211.00
36_D41_A1.5151.00
32_G45_I1.5151.00
44_P47_A1.5071.00
56_F60_N1.5011.00
34_W41_A1.4811.00
35_Q42_G1.4021.00
61_T65_F1.3841.00
83_F86_S1.3711.00
59_S111_A1.3621.00
26_G112_G1.3281.00
15_A67_S1.3211.00
96_V99_F1.3121.00
63_A104_S1.3011.00
85_R88_P1.2861.00
34_W37_D1.2391.00
55_V59_S1.2361.00
16_T71_I1.1961.00
108_A111_A1.1851.00
18_I63_A1.1751.00
94_L100_L1.1641.00
12_L71_I1.1601.00
91_L94_L1.1591.00
64_F76_I1.1571.00
52_R114_Y1.1481.00
24_A28_T1.1371.00
85_R89_R1.1371.00
34_W45_I1.1351.00
60_N109_F1.1051.00
10_S17_L1.1021.00
84_L88_P1.0971.00
31_G53_F1.0471.00
86_S89_R1.0361.00
95_L99_F1.0291.00
65_F71_I1.0271.00
78_T87_L1.0070.99
74_L94_L1.0060.99
20_T28_T1.0040.99
16_T19_A0.9780.99
10_S13_V0.9690.99
63_A66_A0.9660.99
43_T49_K0.9600.99
42_G53_F0.9430.99
21_V64_F0.9330.99
89_R92_I0.9260.99
42_G46_L0.9250.99
47_A50_P0.9230.99
58_I62_I0.9040.99
25_A63_A0.9020.99
23_F27_F0.8870.99
19_A68_L0.8820.99
42_G45_I0.8810.98
37_D45_I0.8760.98
44_P53_F0.8460.98
73_L78_T0.8450.98
27_F108_A0.8430.98
17_L21_V0.8390.98
35_Q45_I0.8370.98
41_A45_I0.8360.98
47_A52_R0.8320.98
80_E97_L0.8280.98
57_F60_N0.8260.98
74_L102_L0.8140.97
20_T30_P0.8090.97
62_I66_A0.8040.97
34_W40_D0.7660.96
10_S16_T0.7570.96
91_L95_L0.7540.96
29_P57_F0.7510.96
92_I100_L0.7410.96
19_A22_T0.7400.96
47_A53_F0.7390.96
20_T24_A0.7370.95
81_D85_R0.7340.95
27_F33_Y0.7330.95
27_F57_F0.7300.95
23_F57_F0.7200.95
95_L105_M0.7180.95
97_L100_L0.7180.95
29_P33_Y0.7180.95
22_T60_N0.7000.94
66_A98_L0.6960.94
23_F101_S0.6890.94
14_V18_I0.6890.94
3_W12_L0.6880.94
66_A100_L0.6880.94
82_D87_L0.6850.93
86_S92_I0.6850.93
50_P55_V0.6800.93
35_Q50_P0.6760.93
80_E83_F0.6760.93
5_K9_N0.6750.93
52_R57_F0.6710.93
27_F114_Y0.6680.93
9_N81_D0.6670.92
77_S90_K0.6650.92
24_A68_L0.6620.92
50_P54_K0.6610.92
35_Q41_A0.6610.92
16_T47_A0.6610.92
62_I104_S0.6550.92
101_S104_S0.6510.92
65_F69_V0.6370.91
17_L20_T0.6340.90
45_I48_K0.6280.90
62_I115_R0.6250.90
26_G64_F0.6250.90
11_L75_L0.6180.89
22_T67_S0.6120.89
72_L90_K0.6120.89
86_S96_V0.6050.88
60_N108_A0.6050.88
52_R58_I0.6040.88
68_L106_M0.6040.88
25_A30_P0.6040.88
93_V107_V0.6010.88
22_T84_L0.5970.88
25_A108_A0.5970.88
12_L88_P0.5950.87
25_A60_N0.5940.87
37_D41_A0.5920.87
29_P71_I0.5920.87
20_T63_A0.5910.87
64_F67_S0.5900.87
102_L113_S0.5900.87
20_T101_S0.5780.86
70_A75_L0.5730.85
82_D86_S0.5700.85
11_L29_P0.5690.85
26_G113_S0.5650.85
32_G35_Q0.5540.84
29_P106_M0.5500.83
101_S105_M0.5490.83
87_L90_K0.5440.82
26_G46_L0.5400.82
28_T94_L0.5400.82
31_G44_P0.5390.82
76_I99_F0.5330.81
77_S93_V0.5240.80
21_V30_P0.5230.80
49_K52_R0.5150.79
12_L69_V0.5130.79
52_R55_V0.5090.78
52_R56_F0.5080.78
9_N13_V0.5020.77
21_V44_P0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o9uB 2 0.7672 2.8 0.929 Contact Map
3cw1L 1 0.1638 2.5 0.931 Contact Map
4or2A 2 0.9483 2 0.934 Contact Map
4a34A 5 0.2845 1.8 0.936 Contact Map
1ci4A 2 0.2586 1.8 0.936 Contact Map
4oo9A 1 0.8793 1.6 0.938 Contact Map
2kbvA 1 0.2241 1.5 0.938 Contact Map
3j39U 1 0.3276 1.5 0.939 Contact Map
4ev6A 3 0.5862 1.4 0.94 Contact Map
4pypA 1 0.8793 1.4 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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