GREMLIN Database
GUB_WAK_bind - Wall-associated receptor kinase galacturonan-binding
PFAM: PF13947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (104)
Sequences: 3479 (2746)
Seq/√Len: 269.3
META: 0.063

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_F93_S3.9121.00
60_T96_R3.4991.00
31_L51_V3.2701.00
41_K50_E2.7111.00
68_S71_C2.7051.00
31_L42_L2.4401.00
84_L88_L2.4321.00
85_S88_L2.2471.00
52_L64_S2.1151.00
20_G30_E2.1131.00
41_K44_L1.9951.00
7_K12_S1.9681.00
53_N62_R1.8891.00
55_S58_N1.7561.00
7_K10_N1.7531.00
40_P44_L1.7471.00
24_G30_E1.7281.00
82_S85_S1.6831.00
73_N76_G1.6091.00
73_N77_S1.6011.00
34_N39_P1.5831.00
89_P92_F1.5641.00
14_P56_L1.5231.00
18_G24_G1.4871.00
89_P93_S1.4851.00
91_F94_S1.4821.00
4_C23_C1.4311.00
84_L87_T1.4261.00
55_S60_T1.4071.00
74_S78_S1.3671.00
82_S86_L1.3621.00
81_N87_T1.2941.00
40_P43_F1.2781.00
50_E64_S1.2511.00
27_P30_E1.2461.00
28_G61_L1.2171.00
68_S72_Y1.1991.00
62_R65_D1.1911.00
90_F94_S1.1501.00
81_N84_L1.1451.00
6_S14_P1.1281.00
5_P20_G1.1241.00
5_P19_I1.0691.00
83_S88_L1.0611.00
52_L62_R1.0481.00
76_G79_S1.0421.00
49_Y63_V1.0331.00
71_C74_S1.0251.00
83_S86_L1.0231.00
74_S77_S0.9731.00
69_S72_Y0.9721.00
38_G42_L0.9701.00
14_P18_G0.9601.00
39_P43_F0.9571.00
11_V59_G0.9341.00
18_G103_G0.9341.00
56_L61_L0.9251.00
78_S81_N0.9201.00
73_N78_S0.9141.00
34_N37_T0.9061.00
18_G22_G0.9001.00
7_K11_V0.9001.00
81_N88_L0.8981.00
39_P42_L0.8941.00
51_V54_I0.8791.00
81_N85_S0.8681.00
69_S74_S0.8681.00
60_T71_C0.8551.00
73_N79_S0.8531.00
19_I31_L0.8461.00
83_S87_T0.8411.00
78_S82_S0.8401.00
67_I72_Y0.8280.99
31_L40_P0.8260.99
79_S82_S0.8200.99
71_C76_G0.8120.99
91_F105_N0.8080.99
80_S87_T0.7830.99
36_S40_P0.7810.99
82_S87_T0.7780.99
27_P46_S0.7770.99
37_T40_P0.7710.99
97_N103_G0.7650.99
93_S99_F0.7640.99
14_P31_L0.7560.99
29_F94_S0.7540.99
49_Y65_D0.7410.99
61_L66_P0.7390.99
82_S88_L0.7350.99
51_V61_L0.7310.99
57_E95_T0.7280.99
61_L65_D0.7130.98
94_S97_N0.7110.98
75_S78_S0.7100.98
6_S12_S0.7100.98
70_D75_S0.7050.98
21_P30_E0.7000.98
9_G23_C0.6980.98
13_I19_I0.6940.98
60_T64_S0.6930.98
12_S58_N0.6910.98
98_K101_V0.6820.98
70_D77_S0.6800.98
55_S62_R0.6760.98
76_G80_S0.6670.98
8_C16_P0.6670.98
35_N39_P0.6660.97
68_S73_N0.6600.97
36_S41_K0.6600.97
21_P48_N0.6560.97
72_Y76_G0.6530.97
36_S57_E0.6480.97
70_D105_N0.6470.97
39_P50_E0.6410.97
21_P27_P0.6400.97
19_I24_G0.6390.97
53_N57_E0.6280.96
14_P97_N0.6160.96
25_L28_G0.6140.96
3_G12_S0.6130.96
15_Y97_N0.6100.96
11_V42_L0.5950.95
29_F33_C0.5950.95
56_L59_G0.5850.95
10_N20_G0.5800.94
26_D94_S0.5730.94
58_N64_S0.5700.94
72_Y79_S0.5660.94
52_L70_D0.5650.94
3_G27_P0.5640.94
60_T94_S0.5600.93
72_Y75_S0.5530.93
5_P26_D0.5480.93
2_P57_E0.5410.92
84_L96_R0.5300.91
2_P63_V0.5290.91
101_V104_C0.5280.91
14_P90_F0.5260.91
5_P32_T0.5250.91
86_L89_P0.5240.91
61_L78_S0.5240.91
4_C9_G0.5190.91
59_G62_R0.5170.90
3_G52_L0.5120.90
70_D73_N0.5110.90
32_T45_G0.5100.90
92_F97_N0.5080.90
58_N91_F0.5080.90
62_R86_L0.5080.90
80_S84_L0.5060.89
24_G27_P0.5060.89
3_G6_S0.5020.89
24_G105_N0.5010.89
11_V46_S0.5010.89
72_Y82_S0.5000.89
31_L41_K0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kdxA 1 0.4245 3 0.924 Contact Map
2cq7A 1 0.1604 2.4 0.928 Contact Map
2hm3A 1 0.1038 2 0.931 Contact Map
1oznA 1 0.8396 1.9 0.932 Contact Map
3j20W 1 0.3868 1.9 0.932 Contact Map
1n7dA 1 0.8491 1.7 0.934 Contact Map
4p8sA 1 0.8396 1.6 0.936 Contact Map
1dvpA 2 0.5566 1.5 0.936 Contact Map
3ml4A 2 0.5377 1.4 0.937 Contact Map
2id5A 3 0.8396 1.4 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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