GREMLIN Database
DUF4212 - Domain of unknown function (DUF4212)
PFAM: PF13937 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (76)
Sequences: 9630 (4157)
Seq/√Len: 476.8
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_A75_E2.6211.00
11_L68_R2.6091.00
68_R71_R2.5741.00
22_V57_V2.3511.00
21_V26_F2.1651.00
64_V68_R2.0791.00
10_R14_I2.0291.00
67_R71_R2.0081.00
33_E36_Q1.9671.00
13_A17_A1.9311.00
30_F33_E1.9041.00
63_F67_R1.9011.00
26_F49_F1.8301.00
38_R41_G1.8071.00
9_L13_A1.7641.00
35_N46_G1.7351.00
33_E37_I1.6521.00
31_A35_N1.6171.00
15_L64_V1.5561.00
25_G29_L1.5521.00
7_A76_Y1.5421.00
45_L49_F1.4681.00
26_F30_F1.3981.00
3_A7_A1.3911.00
23_S58_F1.3811.00
60_V64_V1.2971.00
21_V25_G1.2521.00
14_I18_I1.2211.00
3_A76_Y1.1651.00
14_I17_A1.1631.00
25_G30_F1.1431.00
64_V67_R1.1261.00
17_A21_V1.1221.00
68_R72_L1.1201.00
7_A11_L1.0971.00
3_A6_R1.0941.00
8_N12_T1.0761.00
7_A10_R1.0751.00
38_R44_P1.0411.00
15_L61_L1.0211.00
47_F51_Q1.0181.00
71_R75_E1.0091.00
69_M73_D0.9821.00
37_I45_L0.9641.00
28_I50_A0.9501.00
59_V63_F0.9291.00
14_I64_V0.9091.00
48_W52_Q0.8931.00
69_M72_L0.8431.00
8_N69_M0.8301.00
70_N74_R0.8281.00
40_F43_F0.8281.00
10_R13_A0.8191.00
7_A72_L0.8161.00
62_I65_Y0.7971.00
6_R10_R0.7961.00
18_I61_L0.7901.00
18_I57_V0.7871.00
35_N44_P0.7701.00
24_F28_I0.7611.00
51_Q55_I0.7601.00
11_L72_L0.7461.00
24_F29_L0.7391.00
67_R70_N0.7331.00
2_K6_R0.7281.00
19_W58_F0.7211.00
52_Q56_Y0.7171.00
16_L19_W0.7051.00
40_F45_L0.6961.00
63_F66_A0.6931.00
48_W51_Q0.6871.00
66_A70_N0.6851.00
22_V26_F0.6841.00
4_Y73_D0.6711.00
65_Y69_M0.6711.00
6_R9_L0.6641.00
18_I64_V0.6631.00
71_R74_R0.6591.00
43_F46_G0.6491.00
32_D35_N0.6381.00
38_R43_F0.6311.00
20_F25_G0.6301.00
60_V63_F0.6230.99
27_G50_A0.6220.99
5_W8_N0.6080.99
27_G49_F0.6010.99
31_A43_F0.5920.99
11_L14_I0.5890.99
3_A77_G0.5870.99
4_Y8_N0.5870.99
54_S58_F0.5820.99
15_L18_I0.5710.99
49_F57_V0.5710.99
56_Y60_V0.5680.99
32_D36_Q0.5630.99
31_A44_P0.5620.99
70_N73_D0.5620.99
45_L48_W0.5610.99
14_I68_R0.5550.99
27_G46_G0.5540.99
8_N15_L0.5370.98
40_F44_P0.5360.98
9_L12_T0.5340.98
31_A78_V0.5230.98
57_V61_L0.5210.98
3_A78_V0.5180.98
26_F34_L0.5100.98
55_I59_V0.5090.98
29_L33_E0.5060.98
72_L75_E0.5050.98
50_A53_G0.5040.98
3_A10_R0.5020.98
56_Y62_I0.5010.98
18_I22_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.7975 30.2 0.862 Contact Map
4ev6A 3 0.8228 26.2 0.866 Contact Map
2lonA 1 0.962 9.4 0.89 Contact Map
2kogA 1 0.4051 9.3 0.891 Contact Map
3nd0A 2 0.9241 6.2 0.899 Contact Map
2zxeA 1 0.9114 6 0.9 Contact Map
2wswA 3 0.9494 5.9 0.9 Contact Map
3hd7A 1 0.4051 5.5 0.902 Contact Map
2lomA 1 0.9367 5.1 0.903 Contact Map
4wgvA 2 0.9494 4.6 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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