GREMLIN Database
DUF4209 - Domain of unknown function (DUF4209)
PFAM: PF13910 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (87)
Sequences: 2144 (1766)
Seq/√Len: 189.3
META: 0.877

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_L14_V2.8611.00
59_N62_N2.8281.00
25_K33_D2.7751.00
23_Q55_P2.7581.00
52_L85_L2.3121.00
63_E73_E2.2271.00
37_K42_E2.0461.00
41_G45_V2.0421.00
35_E38_E1.9801.00
25_K29_D1.8831.00
69_L73_E1.7721.00
3_N7_D1.7371.00
5_L30_L1.7111.00
14_V35_E1.6831.00
81_Y84_W1.6641.00
16_T24_E1.6621.00
52_L82_L1.6611.00
51_L85_L1.6091.00
34_P38_E1.5571.00
37_K45_V1.5451.00
32_D49_R1.4751.00
70_D73_E1.4371.00
47_E84_W1.4321.00
36_L45_V1.3541.00
49_R54_D1.3031.00
64_V69_L1.2901.00
23_Q26_G1.2811.00
24_E68_L1.2621.00
36_L40_F1.2371.00
8_L12_A1.2341.00
47_E81_Y1.2211.00
27_L52_L1.1951.00
3_N67_G1.1771.00
31_L53_T1.1731.00
59_N68_L1.1631.00
18_K23_Q1.1451.00
31_L48_L1.1401.00
14_V33_D1.1371.00
31_L45_V1.1141.00
75_N78_Y1.0941.00
80_I84_W1.0441.00
63_E69_L1.0391.00
69_L74_F1.0241.00
37_K49_R1.0010.99
12_A39_I0.9980.99
24_E28_N0.9910.99
45_V49_R0.9860.99
58_L81_Y0.9750.99
28_N32_D0.9720.99
20_D23_Q0.9480.99
31_L36_L0.9460.99
26_G29_D0.9450.99
23_Q28_N0.9280.99
76_S80_I0.9170.99
50_A58_L0.9150.99
12_A15_P0.9010.99
24_E27_L0.8920.99
23_Q29_D0.8890.99
18_K21_R0.8820.99
60_L82_L0.8810.99
26_G32_D0.8740.99
7_D11_L0.8690.99
4_A7_D0.8650.99
19_L22_D0.8620.98
80_I83_W0.8560.98
7_D10_K0.8350.98
18_K22_D0.8270.98
18_K29_D0.8250.98
81_Y85_L0.8170.98
76_S83_W0.8130.98
49_R53_T0.7920.97
29_D32_D0.7920.97
43_D46_F0.7850.97
2_E5_L0.7760.97
57_G65_A0.7680.97
27_L30_L0.7600.97
28_N53_T0.7560.97
10_K16_T0.7350.96
16_T19_L0.7240.96
70_D74_F0.7170.95
64_V74_F0.7090.95
51_L58_L0.7090.95
9_L12_A0.7000.95
49_R56_R0.6900.94
42_E46_F0.6870.94
8_L40_F0.6720.93
51_L81_Y0.6680.93
38_E60_L0.6620.93
33_D36_L0.6540.93
79_A82_L0.6530.92
71_D75_N0.6490.92
53_T65_A0.6470.92
48_L84_W0.6400.92
41_G44_L0.6360.91
46_F50_A0.6360.91
58_L78_Y0.6260.91
40_F44_L0.6240.91
32_D37_K0.6240.91
47_E65_A0.6220.91
17_T21_R0.6210.90
36_L48_L0.6120.90
44_L50_A0.6110.90
30_L39_I0.6080.90
52_L65_A0.6010.89
76_S79_A0.5990.89
51_L60_L0.5970.89
13_G16_T0.5950.89
7_D12_A0.5930.88
55_P59_N0.5930.88
53_T68_L0.5910.88
5_L40_F0.5800.87
47_E58_L0.5770.87
8_L15_P0.5770.87
68_L81_Y0.5750.87
44_L69_L0.5600.85
9_L33_D0.5540.85
36_L41_G0.5270.82
50_A81_Y0.5260.82
6_R13_G0.5250.82
52_L86_L0.5220.81
2_E6_R0.5190.81
58_L62_N0.5090.80
27_L62_N0.5070.79
34_P37_K0.5060.79
21_R41_G0.5050.79
5_L35_E0.5030.79
36_L63_E0.5020.79
59_N63_E0.5010.78
76_S84_W0.5000.78
24_E65_A0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rgpA 2 1 56.3 0.826 Contact Map
3ohwB 1 0.5506 19.6 0.864 Contact Map
3osjA 1 0.5506 14.7 0.871 Contact Map
3nphB 1 0.5506 8.7 0.884 Contact Map
3pruC 1 0.6854 7.8 0.887 Contact Map
2ky4A 1 0.6742 6.7 0.89 Contact Map
1js1X 3 0.9775 5.3 0.895 Contact Map
3oq4A 1 0.3483 4.4 0.899 Contact Map
3oq0A 1 0.1685 4.4 0.899 Contact Map
2w37A 5 0.9326 3.7 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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