GREMLIN Database
DUF4203 - Domain of unknown function (DUF4203)
PFAM: PF13886 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 201 (194)
Sequences: 2704 (2191)
Seq/√Len: 157.3
META: 0.756

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_F193_A5.6491.00
80_A123_A3.1881.00
11_L146_I3.0561.00
33_G67_G2.8771.00
30_F64_G2.8321.00
124_V128_F2.7041.00
84_A119_A2.6531.00
150_I154_A2.6321.00
7_I149_G2.6241.00
18_Y131_R2.5171.00
54_T58_V2.4661.00
135_I197_I2.4231.00
14_C196_G2.3971.00
15_F199_V2.3141.00
105_G108_P2.2621.00
173_W176_Y2.0561.00
139_A197_I2.0411.00
182_S185_Y2.0161.00
26_F68_A1.9891.00
136_V197_I1.9401.00
3_A149_G1.9311.00
26_F72_Y1.8881.00
62_V66_V1.7991.00
76_F130_Q1.7911.00
194_L198_V1.7901.00
113_G117_A1.7731.00
37_G41_I1.7731.00
14_C192_L1.7711.00
86_L137_A1.7471.00
122_G126_A1.7451.00
125_L128_F1.7391.00
146_I192_L1.7351.00
34_A60_A1.7001.00
189_W193_A1.6991.00
183_W187_A1.6781.00
91_G95_L1.6231.00
184_V188_A1.5761.00
85_G88_A1.4961.00
173_W177_P1.4941.00
29_G33_G1.4941.00
59_A63_G1.4931.00
30_F68_A1.4721.00
15_F196_G1.4661.00
95_L98_L1.4441.00
33_G37_G1.4251.00
7_I146_I1.4051.00
38_A56_M1.3871.00
168_R171_N1.3811.00
116_I120_V1.3581.00
58_V62_V1.3331.00
38_A42_G1.3281.00
184_V187_A1.3201.00
29_G71_L1.3171.00
29_G67_G1.3141.00
179_T182_S1.3061.00
151_L157_G1.3061.00
139_A193_A1.3021.00
107_P111_L1.3001.00
144_W189_W1.2981.00
94_L97_A1.2971.00
144_W148_L1.2511.00
120_V123_A1.2441.00
190_L194_L1.2181.00
83_G122_G1.2161.00
193_A197_I1.2141.00
113_G128_F1.2111.00
21_F25_L1.2091.00
10_G149_G1.1971.00
165_L168_R1.1951.00
178_L181_A1.1821.00
75_Y130_Q1.1771.00
83_G124_V1.1731.00
172_V175_L1.1681.00
176_Y180_P1.1671.00
174_V179_T1.1321.00
172_V176_Y1.1281.00
55_A58_V1.1241.00
147_V189_W1.1241.00
63_G67_G1.1211.00
147_V188_A1.1211.00
108_P112_F1.1211.00
151_L185_Y1.1201.00
41_I59_A1.1081.00
167_P170_A1.0920.99
177_P181_A1.0920.99
55_A59_A1.0910.99
119_A123_A1.0870.99
87_G95_L1.0860.99
13_L24_V1.0570.99
196_G200_Q1.0400.99
118_L122_G1.0360.99
173_W180_P1.0290.99
172_V178_L1.0280.99
63_G70_L1.0280.99
148_L151_L1.0240.99
65_L69_L1.0220.99
155_G185_Y1.0210.99
18_Y130_Q1.0210.99
80_A127_L1.0170.99
176_Y179_T1.0150.99
103_I106_D1.0120.99
30_F75_Y1.0000.99
52_S55_A0.9800.99
164_N167_P0.9780.99
173_W179_T0.9750.99
3_A153_L0.9710.99
177_P180_P0.9670.99
174_V178_L0.9660.99
15_F195_L0.9530.99
12_L24_V0.9460.98
34_A38_A0.9410.98
16_F20_L0.9390.98
188_A195_L0.9380.98
135_I139_A0.9340.98
8_L36_L0.9330.98
103_I107_P0.9270.98
151_L155_G0.9070.98
31_I39_S0.9010.98
104_T107_P0.8950.98
87_G91_G0.8930.98
16_F199_V0.8920.98
106_D109_R0.8880.98
94_L98_L0.8880.98
182_S189_W0.8860.98
88_A119_A0.8830.98
80_A84_A0.8780.98
153_L157_G0.8760.97
21_F138_T0.8620.97
133_V137_A0.8620.97
14_C146_I0.8620.97
118_L128_F0.8560.97
28_Y141_G0.8490.97
57_L61_L0.8460.97
169_A172_V0.8420.97
83_G123_A0.8420.97
113_G121_A0.8390.97
148_L156_G0.8300.96
22_R75_Y0.8280.96
117_A120_V0.8280.96
124_V127_L0.8270.96
98_L198_V0.8180.96
4_I8_L0.8140.96
18_Y134_I0.8120.96
106_D111_L0.8090.96
120_V124_V0.8080.96
13_L141_G0.8050.96
148_L157_G0.8040.96
175_L180_P0.8040.96
23_I27_I0.7980.96
69_L73_L0.7980.96
143_A189_W0.7930.95
25_L78_G0.7890.95
8_L11_L0.7840.95
143_A147_V0.7830.95
91_G94_L0.7820.95
157_G185_Y0.7750.95
164_N168_R0.7710.95
157_G160_E0.7680.95
26_F34_A0.7670.95
22_R74_F0.7650.95
92_L95_L0.7620.94
174_V181_A0.7610.94
82_L137_A0.7570.94
175_L181_A0.7550.94
15_F139_A0.7460.94
103_I119_A0.7430.94
115_V119_A0.7380.93
84_A135_I0.7380.93
78_G130_Q0.7370.93
148_L160_E0.7360.93
132_Y136_V0.7280.93
175_L178_L0.7260.93
117_A121_A0.7220.93
67_G71_L0.7190.92
166_L169_A0.7180.92
10_G145_T0.7170.92
38_A63_G0.7160.92
5_L170_A0.7150.92
62_V69_L0.7080.92
60_A70_L0.7070.92
9_G13_L0.7020.92
98_L104_T0.7010.92
93_L111_L0.7000.91
74_F152_A0.6980.91
188_A192_L0.6980.91
61_L65_L0.6970.91
130_Q133_V0.6930.91
78_G88_A0.6880.91
150_I153_L0.6850.91
180_P190_L0.6850.91
20_L138_T0.6840.91
83_G126_A0.6820.90
166_L171_N0.6730.90
113_G120_V0.6700.90
184_V189_W0.6690.90
7_I11_L0.6660.89
53_T57_L0.6610.89
85_G92_L0.6600.89
160_E163_L0.6560.89
75_Y134_I0.6510.88
109_R112_F0.6450.88
89_L189_W0.6390.87
42_G56_M0.6390.87
136_V168_R0.6370.87
27_I37_G0.6350.87
73_L79_V0.6330.87
173_W178_L0.6280.86
191_V194_L0.6270.86
186_L190_L0.6260.86
172_V177_P0.6250.86
79_V130_Q0.6250.86
13_L28_Y0.6210.86
58_V97_A0.6200.86
167_P171_N0.6190.86
154_A157_G0.6150.85
107_P110_W0.6140.85
123_A127_L0.6140.85
42_G46_G0.6110.85
6_L148_L0.6110.85
32_L141_G0.6070.84
156_G181_A0.6060.84
195_L198_V0.6040.84
9_G31_I0.6030.84
25_L29_G0.6020.84
116_I126_A0.6020.84
102_L106_D0.6010.84
20_L30_F0.6010.84
21_F134_I0.5990.84
102_L105_G0.5970.84
157_G161_F0.5970.84
106_D110_W0.5970.84
91_G118_L0.5970.84
41_I60_A0.5970.84
90_L154_A0.5960.83
114_V118_L0.5930.83
132_Y135_I0.5910.83
58_V170_A0.5910.83
26_F38_A0.5890.83
55_A69_L0.5870.82
144_W151_L0.5860.82
39_S43_A0.5860.82
22_R72_Y0.5840.82
28_Y32_L0.5820.82
41_I44_L0.5820.82
169_A178_L0.5730.81
93_L97_A0.5730.81
165_L170_A0.5720.81
165_L169_A0.5700.81
162_L194_L0.5700.81
86_L136_V0.5680.80
144_W147_V0.5680.80
137_A140_F0.5630.80
117_A128_F0.5620.80
5_L90_L0.5610.80
116_I119_A0.5610.80
28_Y41_I0.5600.79
64_G169_A0.5600.79
102_L107_P0.5590.79
174_V180_P0.5580.79
156_G185_Y0.5560.79
7_I150_I0.5500.78
84_A123_A0.5410.77
25_L75_Y0.5400.77
152_A155_G0.5400.77
140_F189_W0.5390.77
37_G64_G0.5380.77
26_F41_I0.5320.76
154_A184_V0.5290.76
58_V65_L0.5290.76
185_Y189_W0.5240.75
20_L141_G0.5240.75
164_N171_N0.5230.75
16_F22_R0.5230.75
127_L131_R0.5220.75
69_L191_V0.5210.74
49_G52_S0.5190.74
28_Y145_T0.5160.74
51_L55_A0.5160.74
89_L95_L0.5150.74
61_L169_A0.5150.74
55_A73_L0.5130.73
28_Y85_G0.5110.73
42_G51_L0.5100.73
148_L158_P0.5090.73
42_G45_F0.5090.73
5_L9_G0.5050.72
36_L40_L0.5040.72
134_I138_T0.5030.72
15_F21_F0.5020.72
89_L126_A0.5000.71
84_A134_I0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ls4A 1 0.1194 3.2 0.934 Contact Map
3j01B 1 0.4776 2.9 0.936 Contact Map
4ev6A 3 0.3831 2.3 0.939 Contact Map
4i0uA 4 0.3731 2.2 0.939 Contact Map
2looA 1 0.4776 2 0.941 Contact Map
5a63B 1 0.2985 1.7 0.943 Contact Map
2zxeG 1 0.1791 1.7 0.944 Contact Map
2ifoA 8 0.1244 1.6 0.944 Contact Map
3o7qA 1 0.6468 1.6 0.944 Contact Map
4p6vB 1 0.5821 1.4 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.