KIAA1430 - PFAM28P - GREMLIN Contacts

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KIAA1430 - KIAA1430 homologue

PFAM:	PF13879	Sequences: HRKRLKNAKPSVDNKPPKTYSHLKLNLKKLQLEEERLAEIERENRILLEKMSKIMRKKSGKSDNRSPYKPKSLNAEKRKRELQRITRENQALLKRLQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	97 (96)
Sequences:	1037 (892)
Seq/√Len:	91.0
META:	0.581

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
81_E	84_R	5.875	1.00
36_R	39_E	3.074	1.00
39_E	43_E	2.612	1.00
5_L	8_A	2.596	1.00
45_R	49_E	2.543	1.00
2_R	5_L	2.091	1.00
63_D	66_S	2.059	1.00
51_M	55_M	2.009	1.00
31_Q	35_E	1.946	1.00
36_R	40_I	1.926	1.00
3_K	7_N	1.900	1.00
46_I	50_K	1.772	1.00
74_N	78_R	1.753	1.00
52_S	55_M	1.736	1.00
84_R	88_E	1.700	1.00
26_N	29_K	1.654	1.00
13_D	17_P	1.547	1.00
82_L	85_I	1.540	1.00
91_A	94_K	1.536	1.00
27_L	31_Q	1.498	1.00
47_L	50_K	1.463	1.00
91_A	95_R	1.444	0.99
92_L	96_L	1.435	0.99
37_L	41_E	1.429	0.99
39_E	42_R	1.401	0.99
62_S	65_R	1.360	0.99
82_L	86_T	1.343	0.99
19_T	22_H	1.340	0.99
76_E	80_R	1.295	0.99
41_E	45_R	1.219	0.98
41_E	55_M	1.219	0.98
87_R	91_A	1.174	0.98
79_K	83_Q	1.169	0.98
49_E	57_K	1.157	0.97
30_L	33_E	1.157	0.97
54_I	74_N	1.136	0.97
25_L	30_L	1.119	0.97
63_D	68_Y	1.098	0.96
78_R	85_I	1.090	0.96
68_Y	71_K	1.082	0.96
60_G	68_Y	1.082	0.96
1_H	4_R	1.062	0.96
33_E	37_L	1.060	0.96
75_A	86_T	1.034	0.95
85_I	89_N	1.031	0.95
38_A	49_E	1.024	0.95
74_N	77_K	1.022	0.95
53_K	57_K	1.005	0.94
51_M	54_I	1.002	0.94
32_L	35_E	0.991	0.94
28_K	31_Q	0.977	0.93
40_I	47_L	0.957	0.93
44_N	47_L	0.954	0.93
75_A	79_K	0.944	0.92
86_T	90_Q	0.937	0.92
52_S	96_L	0.936	0.92
90_Q	93_L	0.936	0.92
6_K	10_P	0.926	0.91
6_K	9_K	0.920	0.91
83_Q	87_R	0.911	0.91
48_L	93_L	0.887	0.89
29_K	32_L	0.884	0.89
13_D	16_P	0.879	0.89
27_L	34_E	0.873	0.89
62_S	68_Y	0.868	0.88
42_R	47_L	0.865	0.88
38_A	45_R	0.864	0.88
16_P	20_Y	0.837	0.87
58_K	79_K	0.835	0.86
38_A	42_R	0.817	0.85
58_K	71_K	0.810	0.85
37_L	48_L	0.803	0.84
51_M	78_R	0.797	0.84
65_R	68_Y	0.786	0.83
61_K	64_N	0.778	0.82
10_P	14_N	0.775	0.82
23_L	26_N	0.769	0.82
32_L	61_K	0.764	0.81
8_A	11_S	0.762	0.81
27_L	33_E	0.759	0.81
77_K	81_E	0.757	0.81
12_V	18_K	0.750	0.80
53_K	80_R	0.747	0.80
62_S	71_K	0.745	0.80
38_A	41_E	0.743	0.79
51_M	85_I	0.735	0.79
59_S	62_S	0.732	0.78
74_N	80_R	0.726	0.78
24_K	52_S	0.724	0.78
5_L	11_S	0.721	0.77
89_N	95_R	0.721	0.77
3_K	19_T	0.720	0.77
3_K	6_K	0.716	0.77
60_G	63_D	0.716	0.77
93_L	96_L	0.715	0.77
40_I	44_N	0.711	0.76
16_P	19_T	0.710	0.76
56_R	70_P	0.707	0.76
31_Q	38_A	0.693	0.74
43_E	46_I	0.690	0.74
5_L	77_K	0.660	0.71
61_K	71_K	0.658	0.71
12_V	86_T	0.658	0.71
44_N	54_I	0.656	0.70
34_E	45_R	0.655	0.70
83_Q	90_Q	0.644	0.69
28_K	41_E	0.618	0.66
50_K	54_I	0.615	0.65
78_R	96_L	0.613	0.65
88_E	94_K	0.611	0.65
49_E	53_K	0.611	0.65
51_M	86_T	0.608	0.65
43_E	50_K	0.605	0.64
33_E	36_R	0.599	0.63
28_K	34_E	0.584	0.61
49_E	90_Q	0.582	0.61
17_P	26_N	0.580	0.61
61_K	86_T	0.575	0.60
38_A	54_I	0.570	0.60
66_S	71_K	0.565	0.59
70_P	76_E	0.564	0.59
11_S	51_M	0.560	0.58
24_K	27_L	0.559	0.58
1_H	5_L	0.557	0.58
28_K	35_E	0.553	0.57
22_H	28_K	0.547	0.56
7_N	10_P	0.547	0.56
41_E	93_L	0.546	0.56
67_P	71_K	0.531	0.54
51_M	81_E	0.530	0.54
4_R	37_L	0.527	0.54
86_T	92_L	0.527	0.54
61_K	66_S	0.519	0.53
70_P	90_Q	0.516	0.52
31_Q	74_N	0.513	0.52
78_R	89_N	0.513	0.52
14_N	19_T	0.512	0.52
37_L	45_R	0.505	0.51
35_E	91_A	0.505	0.51
63_D	73_L	0.503	0.50
69_K	73_L	0.503	0.50
11_S	50_K	0.502	0.50
14_N	17_P	0.501	0.50
49_E	56_R	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1go4E	4	0.8351	17.9	0.84	Contact Map
2mxrA	2	0.2165	1.9	0.9	Contact Map
3o6qB	1	0.4433	1.8	0.901	Contact Map
4c7nB	1	0.5258	1.7	0.903	Contact Map
4bryB	1	0.3402	1.4	0.907	Contact Map
4rxiA	1	0.4845	1	0.916	Contact Map
2j5uA	4	0.2474	0.9	0.918	Contact Map
3brvA	1	0.1959	0.8	0.922	Contact Map
2zxxA	2	0.4536	0.8	0.922	Contact Map
4r3zA	1	0.5773	0.7	0.923	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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