GREMLIN Database
KIAA1430 - KIAA1430 homologue
PFAM: PF13879 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 97 (96)
Sequences: 1037 (892)
Seq/√Len: 91.0
META: 0.581

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_E84_R5.8751.00
36_R39_E3.0741.00
39_E43_E2.6121.00
5_L8_A2.5961.00
45_R49_E2.5431.00
2_R5_L2.0911.00
63_D66_S2.0591.00
51_M55_M2.0091.00
31_Q35_E1.9461.00
36_R40_I1.9261.00
3_K7_N1.9001.00
46_I50_K1.7721.00
74_N78_R1.7531.00
52_S55_M1.7361.00
84_R88_E1.7001.00
26_N29_K1.6541.00
13_D17_P1.5471.00
82_L85_I1.5401.00
91_A94_K1.5361.00
27_L31_Q1.4981.00
47_L50_K1.4631.00
91_A95_R1.4440.99
92_L96_L1.4350.99
37_L41_E1.4290.99
39_E42_R1.4010.99
62_S65_R1.3600.99
82_L86_T1.3430.99
19_T22_H1.3400.99
76_E80_R1.2950.99
41_E45_R1.2190.98
41_E55_M1.2190.98
87_R91_A1.1740.98
79_K83_Q1.1690.98
49_E57_K1.1570.97
30_L33_E1.1570.97
54_I74_N1.1360.97
25_L30_L1.1190.97
63_D68_Y1.0980.96
78_R85_I1.0900.96
68_Y71_K1.0820.96
60_G68_Y1.0820.96
1_H4_R1.0620.96
33_E37_L1.0600.96
75_A86_T1.0340.95
85_I89_N1.0310.95
38_A49_E1.0240.95
74_N77_K1.0220.95
53_K57_K1.0050.94
51_M54_I1.0020.94
32_L35_E0.9910.94
28_K31_Q0.9770.93
40_I47_L0.9570.93
44_N47_L0.9540.93
75_A79_K0.9440.92
86_T90_Q0.9370.92
52_S96_L0.9360.92
90_Q93_L0.9360.92
6_K10_P0.9260.91
6_K9_K0.9200.91
83_Q87_R0.9110.91
48_L93_L0.8870.89
29_K32_L0.8840.89
13_D16_P0.8790.89
27_L34_E0.8730.89
62_S68_Y0.8680.88
42_R47_L0.8650.88
38_A45_R0.8640.88
16_P20_Y0.8370.87
58_K79_K0.8350.86
38_A42_R0.8170.85
58_K71_K0.8100.85
37_L48_L0.8030.84
51_M78_R0.7970.84
65_R68_Y0.7860.83
61_K64_N0.7780.82
10_P14_N0.7750.82
23_L26_N0.7690.82
32_L61_K0.7640.81
8_A11_S0.7620.81
27_L33_E0.7590.81
77_K81_E0.7570.81
12_V18_K0.7500.80
53_K80_R0.7470.80
62_S71_K0.7450.80
38_A41_E0.7430.79
51_M85_I0.7350.79
59_S62_S0.7320.78
74_N80_R0.7260.78
24_K52_S0.7240.78
5_L11_S0.7210.77
89_N95_R0.7210.77
3_K19_T0.7200.77
3_K6_K0.7160.77
60_G63_D0.7160.77
93_L96_L0.7150.77
40_I44_N0.7110.76
16_P19_T0.7100.76
56_R70_P0.7070.76
31_Q38_A0.6930.74
43_E46_I0.6900.74
5_L77_K0.6600.71
61_K71_K0.6580.71
12_V86_T0.6580.71
44_N54_I0.6560.70
34_E45_R0.6550.70
83_Q90_Q0.6440.69
28_K41_E0.6180.66
50_K54_I0.6150.65
78_R96_L0.6130.65
88_E94_K0.6110.65
49_E53_K0.6110.65
51_M86_T0.6080.65
43_E50_K0.6050.64
33_E36_R0.5990.63
28_K34_E0.5840.61
49_E90_Q0.5820.61
17_P26_N0.5800.61
61_K86_T0.5750.60
38_A54_I0.5700.60
66_S71_K0.5650.59
70_P76_E0.5640.59
11_S51_M0.5600.58
24_K27_L0.5590.58
1_H5_L0.5570.58
28_K35_E0.5530.57
22_H28_K0.5470.56
7_N10_P0.5470.56
41_E93_L0.5460.56
67_P71_K0.5310.54
51_M81_E0.5300.54
4_R37_L0.5270.54
86_T92_L0.5270.54
61_K66_S0.5190.53
70_P90_Q0.5160.52
31_Q74_N0.5130.52
78_R89_N0.5130.52
14_N19_T0.5120.52
37_L45_R0.5050.51
35_E91_A0.5050.51
63_D73_L0.5030.50
69_K73_L0.5030.50
11_S50_K0.5020.50
14_N17_P0.5010.50
49_E56_R0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1go4E 4 0.8351 17.9 0.84 Contact Map
2mxrA 2 0.2165 1.9 0.9 Contact Map
3o6qB 1 0.4433 1.8 0.901 Contact Map
4c7nB 1 0.5258 1.7 0.903 Contact Map
4bryB 1 0.3402 1.4 0.907 Contact Map
4rxiA 1 0.4845 1 0.916 Contact Map
2j5uA 4 0.2474 0.9 0.918 Contact Map
3brvA 1 0.1959 0.8 0.922 Contact Map
2zxxA 2 0.4536 0.8 0.922 Contact Map
4r3zA 1 0.5773 0.7 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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