GREMLIN Database
TPH - Trichohyalin-plectin-homology domain
PFAM: PF13868 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 346 (341)
Sequences: 1356 (996)
Seq/√Len: 53.9
META: 0.294

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_E50_R4.1891.00
218_K222_E3.0471.00
221_K225_E2.8571.00
223_E227_R2.8151.00
225_E229_R2.6041.00
145_E149_E2.4821.00
228_A232_L2.4271.00
62_E66_E2.4191.00
289_R293_E2.3011.00
116_E120_E2.2981.00
56_R60_K2.2871.00
177_R181_K2.2421.00
155_L159_K2.2141.00
232_L236_E2.2021.00
276_E280_K2.1881.00
272_E276_E2.1661.00
173_R177_R2.1261.00
47_E51_L2.1211.00
229_R233_E2.1011.00
63_K67_E2.0691.00
142_Q145_E2.0641.00
142_Q146_E2.0491.00
210_E214_R2.0371.00
215_K219_K2.0021.00
156_E160_E1.9971.00
105_E108_K1.9631.00
312_E315_E1.9591.00
55_E59_E1.9441.00
184_A188_E1.9381.00
124_E128_E1.8850.99
201_E205_A1.8780.99
226_K230_L1.8650.99
283_E287_E1.8510.99
170_A174_E1.8390.99
59_E62_E1.8250.99
247_E251_E1.8110.99
171_E174_E1.7930.99
107_I110_E1.7810.99
141_A145_E1.7780.99
218_K221_K1.7530.99
159_K163_E1.7400.99
261_E265_E1.7280.99
149_E153_K1.7250.99
106_L110_E1.7140.99
118_K122_K1.7100.99
59_E63_K1.7010.99
38_E41_R1.6960.99
281_R285_K1.6860.99
112_E116_E1.6710.99
282_R286_L1.6590.99
3_D6_R1.6540.99
51_L55_E1.6520.99
216_W219_K1.6370.98
266_K270_D1.6350.98
276_E279_E1.6340.98
143_E146_E1.6330.98
272_E275_K1.6330.98
206_E210_E1.6260.98
192_K196_E1.6200.98
21_R24_Q1.6190.98
321_E324_R1.6180.98
279_E283_E1.6150.98
243_A247_E1.6120.98
168_R172_K1.6110.98
26_E29_K1.6070.98
227_R231_R1.6050.98
57_E60_K1.5990.98
152_R156_E1.5830.98
117_E120_E1.5590.98
134_E137_K1.5450.98
138_E141_A1.5140.97
321_E325_E1.5130.97
174_E178_E1.5070.97
146_E150_E1.5000.97
193_E196_E1.4940.97
288_H292_L1.4930.97
64_R68_R1.4820.97
176_K180_E1.4820.97
250_A254_E1.4640.97
127_R131_E1.4640.97
95_E98_E1.4530.97
166_E170_A1.4500.97
145_E148_E1.4480.97
178_E181_K1.4270.96
144_K148_E1.4200.96
49_E52_K1.4180.96
66_E70_E1.4180.96
265_E268_E1.4100.96
29_K32_K1.3990.96
80_E83_E1.3970.96
113_R116_E1.3960.96
192_K195_D1.3950.96
56_R59_E1.3950.96
167_E171_E1.3910.96
287_E291_E1.3900.96
240_E244_E1.3720.95
117_E121_K1.3600.95
217_R220_E1.3600.95
109_E113_R1.3600.95
208_A211_E1.3410.95
120_E123_K1.3400.95
102_E106_L1.3290.95
31_I35_E1.3260.94
244_E248_R1.3260.94
55_E58_E1.3220.94
156_E159_K1.3220.94
249_K253_K1.3210.94
35_E38_E1.3140.94
105_E109_E1.3130.94
64_R67_E1.3090.94
257_K261_E1.2970.94
287_E290_R1.2960.94
236_E240_E1.2890.94
98_E102_E1.2790.93
103_Q107_I1.2790.93
229_R232_L1.2780.93
183_R187_R1.2710.93
9_E13_L1.2640.93
50_R54_L1.2570.93
87_E91_E1.2540.93
44_E48_E1.2420.92
163_E167_E1.2330.92
152_R155_L1.2320.92
76_L79_I1.2300.92
160_E163_E1.2270.92
258_E262_R1.2200.92
13_L17_V1.2110.91
65_K69_K1.2090.91
251_E254_E1.2090.91
213_E217_R1.2070.91
227_R230_L1.1980.91
194_Q197_R1.1940.91
286_L289_R1.1750.90
319_E322_E1.1750.90
335_K339_L1.1700.90
219_K223_E1.1640.90
224_A228_A1.1640.90
187_R190_Q1.1610.89
297_E301_Q1.1610.89
224_A227_R1.1580.89
258_E261_E1.1570.89
138_E142_Q1.1570.89
57_E61_E1.1490.89
14_L18_N1.1490.89
84_E88_E1.1440.89
253_K257_K1.1380.88
148_E152_R1.1380.88
23_A26_E1.1360.88
63_K66_E1.1340.88
46_M49_E1.1320.88
182_E186_L1.1270.88
186_L190_Q1.1260.88
141_A144_K1.1240.88
331_E335_K1.1230.88
308_E312_E1.1230.88
337_E341_A1.1220.88
23_A27_E1.1160.87
33_E37_E1.1130.87
121_K124_E1.1100.87
131_E135_E1.1100.87
88_E91_E1.1030.87
318_R322_E1.0980.87
40_K44_E1.0960.87
135_E138_E1.0910.86
162_E165_E1.0900.86
243_A246_E1.0880.86
214_R218_K1.0820.86
45_L49_E1.0800.86
280_K284_K1.0790.86
126_R130_E1.0750.85
164_R168_R1.0740.85
246_E250_A1.0710.85
211_E215_K1.0710.85
265_E269_E1.0680.85
268_E272_E1.0650.85
85_Q89_A1.0590.85
113_R117_E1.0580.85
171_E175_I1.0570.84
254_E258_E1.0560.84
326_E330_E1.0560.84
307_K310_E1.0470.84
179_K183_R1.0450.84
28_K32_K1.0420.84
251_E255_E1.0410.84
180_E187_R1.0380.83
215_K218_K1.0320.83
298_E302_Q1.0280.83
178_E186_L1.0270.83
185_R188_E1.0230.82
212_A216_W1.0170.82
69_K73_E1.0150.82
234_L238_R1.0150.82
213_E216_W1.0150.82
67_E70_E1.0130.82
71_G75_L1.0040.81
37_E40_K1.0030.81
228_A231_R1.0020.81
316_A319_E0.9960.81
200_E204_R0.9910.80
275_K278_K0.9890.80
119_R122_K0.9870.80
329_E332_R0.9860.80
239_E242_I0.9860.80
48_E52_K0.9850.80
290_R293_E0.9840.80
268_E271_E0.9840.80
305_A308_E0.9800.80
217_R221_K0.9790.80
115_K118_K0.9740.79
157_Y161_K0.9740.79
134_E138_E0.9720.79
248_R252_E0.9710.79
52_K56_R0.9700.79
326_E329_E0.9630.78
333_Q337_E0.9630.78
58_E62_E0.9620.78
336_L340_A0.9600.78
123_K127_R0.9570.78
246_E249_K0.9540.78
179_K182_E0.9520.78
216_W220_E0.9450.77
95_E99_L0.9440.77
139_R143_E0.9430.77
305_A309_E0.9400.77
38_E42_L0.9360.76
94_E97_K0.9350.76
271_E275_K0.9330.76
191_E194_Q0.9330.76
43_D47_E0.9320.76
225_E232_L0.9310.76
46_M50_R0.9300.76
172_K175_I0.9290.76
193_E197_R0.9280.76
93_K97_K0.9200.75
174_E177_R0.9160.75
91_E95_E0.9140.75
247_E250_A0.9120.75
195_D198_E0.9110.74
162_E166_E0.9100.74
90_K94_E0.9080.74
133_N136_Q0.9060.74
275_K279_E0.9050.74
181_K185_R0.9030.74
120_E124_E0.9030.74
297_E300_R0.9010.74
325_E332_R0.9000.74
72_A76_L0.8970.73
301_Q305_A0.8950.73
172_K176_K0.8950.73
190_Q193_E0.8940.73
209_Q213_E0.8920.73
130_E134_E0.8880.73
73_E77_E0.8870.72
36_K40_K0.8850.72
26_E30_E0.8850.72
222_E225_E0.8780.72
115_K119_R0.8760.72
308_E311_L0.8750.71
311_L315_E0.8720.71
182_E185_R0.8660.71
42_L46_M0.8650.71
8_L18_N0.8640.70
102_E105_E0.8610.70
202_E206_E0.8610.70
300_R304_E0.8560.70
222_E226_K0.8530.70
235_L238_R0.8500.69
179_K186_L0.8490.69
175_I179_K0.8470.69
199_E202_E0.8450.69
256_E259_E0.8410.68
30_E33_E0.8380.68
189_Q192_K0.8370.68
327_R330_E0.8350.68
241_Q295_Q0.8340.68
5_L8_L0.8330.68
8_L15_A0.8320.68
182_E187_R0.8310.67
235_L239_E0.8300.67
45_L48_E0.8290.67
3_D133_N0.8260.67
161_K164_R0.8260.67
123_K126_R0.8200.66
337_E340_A0.8180.66
260_R264_L0.8180.66
309_E313_E0.8160.66
322_E326_E0.8160.66
39_E43_D0.8160.66
191_E195_D0.8140.66
147_E150_E0.8130.66
65_K68_R0.8110.66
28_K31_I0.8100.65
101_K105_E0.8100.65
301_Q304_E0.8050.65
306_E336_L0.8030.65
315_E318_R0.8020.65
323_E326_E0.7940.64
190_Q194_Q0.7930.64
164_R167_E0.7890.63
317_L320_E0.7880.63
79_I213_E0.7850.63
328_I331_E0.7840.63
49_E53_A0.7810.63
263_L267_L0.7800.63
97_K101_K0.7800.63
197_R201_E0.7790.62
5_L15_A0.7790.62
266_K269_E0.7780.62
196_E200_E0.7710.62
175_I178_E0.7690.61
53_A57_E0.7680.61
80_E84_E0.7600.61
54_L58_E0.7600.61
239_E243_A0.7600.61
179_K184_A0.7580.60
158_A162_E0.7560.60
291_E294_K0.7540.60
257_K260_R0.7490.59
94_E98_E0.7460.59
22_D118_K0.7400.58
192_K199_E0.7370.58
330_E333_Q0.7320.58
30_E34_E0.7310.58
152_R159_K0.7290.57
16_K339_L0.7290.57
47_E54_L0.7260.57
109_E112_E0.7250.57
183_R195_D0.7250.57
170_A173_R0.7250.57
83_E86_R0.7230.57
198_E201_E0.7230.57
188_E192_K0.7200.56
321_E328_I0.7190.56
252_E255_E0.7170.56
103_Q106_L0.7140.56
85_Q88_E0.7130.56
197_R200_E0.7080.55
46_M53_A0.7070.55
184_A187_R0.7070.55
159_K252_E0.7040.55
314_G318_R0.6980.54
207_L210_E0.6970.54
72_A238_R0.6970.54
279_E282_R0.6950.54
176_K179_K0.6940.54
332_R336_L0.6940.54
305_A310_E0.6940.54
307_K311_L0.6930.54
183_R194_Q0.6880.53
125_L128_E0.6840.53
278_K282_R0.6820.52
269_E273_K0.6820.52
4_E12_L0.6810.52
151_D154_I0.6790.52
187_R191_E0.6690.51
138_E143_E0.6650.51
32_K44_E0.6650.51
211_E225_E0.6630.50
188_E191_E0.6630.50
150_E153_K0.6620.50
79_I82_R0.6600.50
286_L290_R0.6560.50
110_E113_R0.6510.49
281_R284_K0.6480.49
320_E324_R0.6480.49
199_E203_L0.6480.49
276_E283_E0.6470.49
10_S13_L0.6440.48
327_R331_E0.6430.48
262_R266_K0.6420.48
84_E87_E0.6410.48
75_L194_Q0.6370.48
261_E264_L0.6360.47
21_R238_R0.6350.47
292_L299_R0.6330.47
136_Q140_K0.6320.47
283_E286_L0.6320.47
179_K219_K0.6300.47
126_R129_L0.6300.47
22_D25_I0.6300.47
143_E147_E0.6300.47
194_Q200_E0.6300.47
39_E105_E0.6300.47
167_E170_A0.6280.47
157_Y162_E0.6270.47
183_R186_L0.6240.46
294_K297_E0.6220.46
245_K274_E0.6210.46
178_E182_E0.6210.46
4_E328_I0.6200.46
114_E117_E0.6180.46
61_E64_R0.6180.46
124_E127_R0.6150.45
163_E166_E0.6140.45
104_V107_I0.6130.45
207_L211_E0.6110.45
324_R328_I0.6090.45
63_K322_E0.6080.45
292_L296_I0.6070.44
8_L14_L0.6070.44
315_E319_E0.6050.44
116_E119_R0.6040.44
82_R85_Q0.6030.44
3_D21_R0.6010.44
255_E258_E0.6000.44
173_R188_E0.5990.44
197_R202_E0.5990.44
70_E73_E0.5970.43
196_E199_E0.5960.43
4_E18_N0.5950.43
202_E205_A0.5940.43
80_E326_E0.5920.43
328_I332_R0.5920.43
106_L109_E0.5880.42
309_E312_E0.5870.42
67_E71_G0.5860.42
286_L293_E0.5840.42
261_E268_E0.5810.42
18_N22_D0.5790.41
2_S6_R0.5790.41
16_K27_E0.5790.41
67_E242_I0.5780.41
226_K231_R0.5730.41
31_I34_E0.5710.41
330_E334_R0.5700.41
212_A215_K0.5700.41
33_E36_K0.5670.40
66_E69_K0.5660.40
132_A137_K0.5630.40
6_R14_L0.5610.40
32_K336_L0.5600.40
43_D54_L0.5600.40
304_E308_E0.5590.39
155_L158_A0.5590.39
265_E291_E0.5590.39
52_K55_E0.5560.39
108_K112_E0.5540.39
8_L11_K0.5540.39
259_E263_L0.5530.39
280_K283_E0.5490.38
51_L54_L0.5480.38
221_K229_R0.5480.38
192_K217_R0.5480.38
238_R241_Q0.5470.38
12_L19_K0.5460.38
221_K224_A0.5450.38
180_E183_R0.5430.38
165_E210_E0.5420.38
186_L194_Q0.5390.37
154_I157_Y0.5390.37
289_R296_I0.5380.37
335_K338_E0.5380.37
185_R189_Q0.5380.37
78_Q241_Q0.5350.37
179_K256_E0.5340.37
47_E79_I0.5330.37
232_L337_E0.5330.37
237_A240_E0.5330.37
243_A258_E0.5320.37
302_Q306_E0.5300.37
50_R79_I0.5300.37
309_E316_A0.5300.37
109_E116_E0.5290.36
167_E174_E0.5290.36
25_I51_L0.5280.36
91_E99_L0.5270.36
205_A208_A0.5270.36
13_L16_K0.5270.36
86_R217_R0.5250.36
220_E226_K0.5250.36
116_E337_E0.5240.36
155_L162_E0.5230.36
231_R234_L0.5220.36
2_S5_L0.5210.36
6_R132_A0.5210.36
29_K33_E0.5200.36
207_L331_E0.5200.36
299_R303_R0.5190.35
150_E287_E0.5190.35
179_K187_R0.5180.35
180_E205_A0.5180.35
16_K20_E0.5170.35
60_K64_R0.5170.35
5_L9_E0.5160.35
313_E317_L0.5160.35
173_R176_K0.5140.35
70_E74_V0.5140.35
97_K104_V0.5130.35
44_E70_E0.5130.35
325_E328_I0.5130.35
292_L295_Q0.5120.35
60_K63_K0.5120.35
23_A210_E0.5100.35
10_S17_V0.5100.35
189_Q194_Q0.5100.35
143_E149_E0.5090.34
179_K190_Q0.5080.34
208_A212_A0.5080.34
3_D7_E0.5080.34
7_E10_S0.5070.34
96_E259_E0.5070.34
122_K130_E0.5070.34
53_A56_R0.5060.34
198_E205_A0.5060.34
56_R244_E0.5040.34
198_E202_E0.5030.34
265_E274_E0.5030.34
206_E214_R0.5020.34
8_L20_E0.5010.34
21_R25_I0.5010.34
229_R280_K0.5000.34
113_R145_E0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ww6A 3 0.0347 1.1 0.96 Contact Map
2lnmA 1 0.0607 0.9 0.962 Contact Map
4w4mA 1 0.0809 0.9 0.963 Contact Map
3j60G 1 0.1763 0.9 0.963 Contact Map
4ujpH 1 0.1734 0.8 0.963 Contact Map
1to2I 1 0.0636 0.8 0.964 Contact Map
2nzcA 3 0.078 0.8 0.964 Contact Map
2iboA 4 0.104 0.8 0.964 Contact Map
2akfA 3 0.0434 0.8 0.964 Contact Map
4u7iA 1 0.0925 0.7 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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