GREMLIN Database
Enkurin - Calmodulin-binding
PFAM: PF13864 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 98 (97)
Sequences: 993 (776)
Seq/√Len: 78.8
META: 0.555

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_R47_L2.7761.00
77_K81_E2.5751.00
47_L94_F2.1761.00
54_W84_L2.1351.00
89_K92_K2.1081.00
40_E43_R2.0951.00
54_W58_N1.9461.00
85_K89_K1.9201.00
69_D73_K1.8681.00
12_E16_R1.8471.00
51_K54_W1.7971.00
20_E24_Y1.7871.00
36_R42_E1.7531.00
59_K63_K1.7421.00
57_L87_L1.7091.00
16_R19_E1.6861.00
22_R25_V1.6801.00
1_G4_P1.6011.00
15_E19_E1.5991.00
86_Q90_D1.5971.00
22_R26_E1.5220.99
47_L91_I1.4860.99
89_K93_K1.4620.99
18_Q22_R1.4360.99
24_Y27_E1.4320.99
46_L94_F1.4170.99
14_I17_E1.4150.99
10_R14_I1.3610.99
21_I24_Y1.3420.98
27_E30_E1.3370.98
54_W88_E1.3190.98
52_K55_E1.3150.98
50_L87_L1.2880.98
23_E26_E1.2740.98
66_V71_L1.2550.98
90_D94_F1.2410.97
57_L80_L1.2220.97
26_E41_E1.2170.97
17_E20_E1.2160.97
3_V8_E1.2110.97
16_R20_E1.2010.97
2_K8_E1.1910.97
19_E23_E1.1870.97
54_W62_Q1.1820.96
7_L11_K1.1600.96
61_Y81_E1.1540.96
1_G6_Y1.1470.96
46_L90_D1.1240.95
20_E23_E1.1150.95
17_E21_I1.0960.95
39_S42_E1.0960.95
44_L48_E1.0770.94
73_K76_R1.0680.94
18_Q24_Y1.0620.94
53_K83_E1.0550.93
82_K85_K1.0540.93
32_P35_M1.0540.93
5_K9_K1.0540.93
55_E59_K1.0340.93
58_N62_Q1.0060.92
48_E52_K0.9690.90
52_K56_E0.9690.90
40_E44_L0.9570.90
83_E86_Q0.9470.89
78_E82_K0.9450.89
8_E11_K0.9340.88
25_V28_D0.9250.88
61_Y90_D0.9100.87
27_E31_C0.8820.85
92_K96_K0.8780.85
51_K91_I0.8580.84
18_Q21_I0.8580.84
87_L95_S0.8550.84
57_L84_L0.8220.81
21_I25_V0.8140.80
10_R13_E0.8120.80
43_R91_I0.7950.79
2_K5_K0.7950.79
75_R79_E0.7750.77
25_V29_P0.7730.77
69_D76_R0.7690.77
54_W61_Y0.7690.77
62_Q73_K0.7640.76
15_E18_Q0.7550.75
11_K15_E0.7470.74
31_C34_G0.7370.73
57_L75_R0.7360.73
54_W91_I0.7330.73
64_L73_K0.7200.72
41_E52_K0.7190.72
82_K86_Q0.7170.71
23_E27_E0.7160.71
8_E12_E0.7140.71
58_N64_L0.7070.70
77_K88_E0.7070.70
37_L74_K0.7010.70
45_E49_G0.6950.69
70_T73_K0.6870.68
30_E36_R0.6870.68
68_L77_K0.6820.68
46_L54_W0.6820.68
41_E45_E0.6750.67
41_E85_K0.6700.66
68_L73_K0.6700.66
19_E22_R0.6550.64
34_G47_L0.6490.64
66_V73_K0.6330.62
49_G60_E0.6250.61
33_P84_L0.6220.60
34_G80_L0.6220.60
36_R41_E0.6210.60
4_P7_L0.6170.60
61_Y64_L0.6160.60
9_K12_E0.6150.60
11_K14_I0.6140.59
82_K92_K0.6130.59
38_L43_R0.6120.59
74_K77_K0.6080.59
15_E27_E0.6080.59
10_R20_E0.5990.58
16_R26_E0.5950.57
66_V69_D0.5820.55
62_Q69_D0.5800.55
12_E15_E0.5790.55
72_G76_R0.5740.54
67_K78_E0.5730.54
79_E83_E0.5700.54
15_E29_P0.5680.54
66_V72_G0.5570.52
24_Y49_G0.5560.52
41_E89_K0.5530.52
50_L58_N0.5510.51
53_K94_F0.5470.51
35_M73_K0.5420.50
53_K87_L0.5400.50
51_K62_Q0.5360.50
53_K80_L0.5330.49
8_E16_R0.5260.48
59_K80_L0.5190.47
26_E31_C0.5180.47
5_K8_E0.5180.47
94_F97_P0.5160.47
35_M67_K0.5140.47
14_I18_Q0.5060.46
24_Y28_D0.5060.46
7_L25_V0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i00A 2 0.5816 18.2 0.874 Contact Map
3ghgA 2 0.9694 8.1 0.893 Contact Map
2ke4A 1 0.3878 7.2 0.895 Contact Map
3ci9A 5 0.4898 7 0.895 Contact Map
1ysmA 1 0.5 7 0.896 Contact Map
1l8dA 2 0.8673 5.8 0.899 Contact Map
3qprA 8 0.0102 5 0.903 Contact Map
2lw1A 1 0.3265 4.7 0.904 Contact Map
2p22A 1 0.602 4.6 0.904 Contact Map
3szaA 2 0.8061 4.2 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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