BCIP - PFAM28P - GREMLIN Contacts

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BCIP - p21-C-terminal region-binding protein

PFAM:	PF13862	Sequences: EVNVDFEFFDPNPEDFHGIKTLLQQLFFLDAQLFDLSELADLILSQPTVGSVVKVDGDESDPVYAFLTVLNLTEHKDKPCIKQLKEYLLSKCEKNASLAQLKKLLSDSSSKPVGLLLSERLINMPPQIVPPLYKMLLEEIEWAVEDNEPYKFTHYLIISKTYKEVESKLKKKKKKKKKKKAQKEEELFYFHPEDEIF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	197 (197)
Sequences:	654 (493)
Seq/√Len:	35.1
META:	0.191

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_F	37_S	6.649	1.00
66_F	117_L	5.150	1.00
35_D	38_E	4.855	1.00
10_D	142_W	4.571	1.00
16_F	20_K	3.703	1.00
43_I	68_T	3.404	1.00
8_F	51_S	3.298	1.00
118_S	133_Y	2.931	1.00
12_N	58_D	2.754	1.00
69_V	114_G	2.727	1.00
15_D	54_K	2.485	1.00
80_C	83_Q	2.409	1.00
76_K	99_A	2.384	1.00
112_P	153_T	2.353	0.99
35_D	79_P	2.124	0.99
46_Q	50_G	1.961	0.98
88_L	156_L	1.940	0.98
13_P	44_L	1.897	0.98
191_H	194_D	1.884	0.97
67_L	133_Y	1.882	0.97
116_L	157_I	1.837	0.97
10_D	49_V	1.831	0.97
170_K	177_K	1.755	0.96
37_S	41_D	1.749	0.96
18_G	153_T	1.730	0.96
17_H	37_S	1.726	0.96
27_F	158_I	1.701	0.95
171_K	177_K	1.673	0.95
79_P	83_Q	1.658	0.95
49_V	143_A	1.642	0.94
137_L	155_Y	1.623	0.94
177_K	180_K	1.603	0.93
170_K	173_K	1.577	0.93
19_I	40_A	1.521	0.92
11_P	53_V	1.447	0.89
20_K	41_D	1.442	0.89
67_L	129_V	1.436	0.89
114_G	152_F	1.426	0.89
21_T	168_K	1.412	0.88
129_V	142_W	1.411	0.88
134_K	138_E	1.410	0.88
36_L	88_L	1.397	0.88
20_K	44_L	1.395	0.88
107_D	110_S	1.365	0.86
176_K	179_K	1.340	0.85
69_V	116_L	1.339	0.85
16_F	41_D	1.319	0.84
40_A	44_L	1.313	0.84
13_P	47_P	1.276	0.82
18_G	126_P	1.263	0.82
138_E	146_D	1.260	0.82
57_G	191_H	1.257	0.81
23_L	117_L	1.244	0.81
104_L	113_V	1.236	0.80
9_F	15_D	1.201	0.78
72_L	89_L	1.199	0.78
138_E	142_W	1.195	0.78
11_P	142_W	1.193	0.78
45_S	93_E	1.191	0.78
25_Q	119_E	1.182	0.77
83_Q	86_E	1.170	0.76
11_P	69_V	1.161	0.76
9_F	130_P	1.149	0.75
170_K	174_K	1.140	0.74
3_N	138_E	1.136	0.74
173_K	180_K	1.121	0.73
35_D	83_Q	1.117	0.73
57_G	60_S	1.106	0.72
186_E	189_Y	1.104	0.72
37_S	155_Y	1.092	0.71
176_K	183_K	1.082	0.71
34_F	87_Y	1.071	0.70
172_K	177_K	1.070	0.70
19_I	113_V	1.069	0.70
142_W	145_E	1.067	0.69
42_L	45_S	1.065	0.69
73_T	76_K	1.063	0.69
171_K	178_K	1.060	0.69
105_L	145_E	1.056	0.69
171_K	174_K	1.044	0.68
175_K	179_K	1.040	0.67
121_L	124_M	1.040	0.67
128_I	190_F	1.031	0.67
53_V	128_I	1.030	0.67
159_S	194_D	1.026	0.66
71_N	150_Y	1.024	0.66
119_E	129_V	1.023	0.66
107_D	176_K	1.021	0.66
144_V	150_Y	1.016	0.66
17_H	41_D	1.010	0.65
38_E	78_K	1.008	0.65
8_F	28_F	1.004	0.65
42_L	75_H	1.004	0.65
124_M	135_M	1.003	0.65
104_L	154_H	0.998	0.64
40_A	103_K	0.996	0.64
13_P	175_K	0.988	0.63
119_E	124_M	0.986	0.63
21_T	118_S	0.985	0.63
25_Q	34_F	0.983	0.63
24_Q	28_F	0.982	0.63
114_G	150_Y	0.982	0.63
36_L	187_L	0.971	0.62
176_K	180_K	0.960	0.61
35_D	160_K	0.959	0.61
189_Y	194_D	0.937	0.59
43_I	136_L	0.926	0.58
135_M	149_P	0.925	0.58
50_G	120_R	0.917	0.58
147_N	151_K	0.915	0.57
46_Q	142_W	0.913	0.57
47_P	53_V	0.912	0.57
116_L	155_Y	0.911	0.57
185_E	188_F	0.908	0.57
140_I	146_D	0.905	0.57
1_E	128_I	0.903	0.56
31_A	121_L	0.903	0.56
55_V	129_V	0.892	0.55
173_K	179_K	0.891	0.55
143_A	149_P	0.886	0.55
38_E	79_P	0.885	0.55
95_N	98_L	0.878	0.54
8_F	18_G	0.864	0.53
55_V	60_S	0.863	0.53
177_K	183_K	0.861	0.53
130_P	194_D	0.860	0.53
65_A	162_Y	0.855	0.52
40_A	184_E	0.853	0.52
113_V	154_H	0.850	0.52
174_K	177_K	0.848	0.52
69_V	155_Y	0.847	0.52
19_I	66_F	0.845	0.51
86_E	93_E	0.844	0.51
178_K	181_A	0.842	0.51
141_E	147_N	0.840	0.51
164_E	188_F	0.836	0.51
38_E	121_L	0.834	0.50
54_K	139_E	0.834	0.50
60_S	134_K	0.832	0.50
68_T	116_L	0.832	0.50
143_A	152_F	0.831	0.50
7_E	56_D	0.828	0.50
8_F	129_V	0.813	0.49
66_F	118_S	0.806	0.48
26_L	65_A	0.801	0.48
188_F	197_F	0.792	0.47
55_V	121_L	0.791	0.47
168_K	186_E	0.791	0.47
158_I	163_K	0.785	0.46
103_K	107_D	0.779	0.46
139_E	149_P	0.778	0.46
18_G	28_F	0.776	0.46
72_L	84_L	0.775	0.45
173_K	177_K	0.774	0.45
17_H	20_K	0.774	0.45
20_K	37_S	0.770	0.45
49_V	142_W	0.768	0.45
115_L	156_L	0.764	0.44
10_D	51_S	0.762	0.44
50_G	105_L	0.762	0.44
111_K	153_T	0.761	0.44
44_L	139_E	0.761	0.44
36_L	40_A	0.761	0.44
30_D	115_L	0.758	0.44
37_S	189_Y	0.752	0.43
124_M	190_F	0.751	0.43
189_Y	193_E	0.749	0.43
19_I	107_D	0.746	0.43
175_K	178_K	0.741	0.43
48_T	142_W	0.741	0.43
180_K	184_E	0.736	0.42
71_N	74_E	0.733	0.42
40_A	110_S	0.732	0.42
11_P	19_I	0.731	0.42
46_Q	195_E	0.724	0.41
137_L	144_V	0.718	0.41
183_K	186_E	0.715	0.40
48_T	146_D	0.715	0.40
53_V	148_E	0.710	0.40
15_D	131_P	0.709	0.40
2_V	5_D	0.708	0.40
40_A	136_L	0.701	0.39
46_Q	113_V	0.699	0.39
74_E	78_K	0.698	0.39
54_K	162_Y	0.693	0.39
18_G	52_V	0.691	0.38
42_L	157_I	0.680	0.38
173_K	176_K	0.677	0.37
19_I	59_E	0.677	0.37
43_I	59_E	0.676	0.37
61_D	116_L	0.676	0.37
34_F	43_I	0.674	0.37
54_K	69_V	0.673	0.37
64_Y	194_D	0.671	0.37
70_L	101_L	0.670	0.37
72_L	90_S	0.669	0.37
25_Q	31_A	0.669	0.37
13_P	71_N	0.666	0.36
135_M	139_E	0.662	0.36
15_D	139_E	0.657	0.36
101_L	138_E	0.654	0.35
11_P	43_I	0.650	0.35
8_F	160_K	0.646	0.35
146_D	155_Y	0.645	0.35
21_T	189_Y	0.644	0.35
11_P	46_Q	0.643	0.35
48_T	145_E	0.643	0.35
67_L	157_I	0.639	0.34
71_N	114_G	0.639	0.34
87_Y	190_F	0.638	0.34
9_F	13_P	0.638	0.34
51_S	139_E	0.633	0.34
169_L	177_K	0.633	0.34
74_E	112_P	0.632	0.34
30_D	87_Y	0.631	0.34
86_E	163_K	0.628	0.33
174_K	181_A	0.627	0.33
172_K	175_K	0.626	0.33
26_L	159_S	0.625	0.33
83_Q	163_K	0.625	0.33
90_S	93_E	0.622	0.33
23_L	131_P	0.620	0.33
47_P	143_A	0.619	0.33
109_S	197_F	0.618	0.33
160_K	188_F	0.616	0.33
46_Q	140_I	0.614	0.32
69_V	136_L	0.613	0.32
68_T	195_E	0.613	0.32
34_F	117_L	0.610	0.32
23_L	50_G	0.608	0.32
139_E	155_Y	0.606	0.32
159_S	192_P	0.602	0.31
2_V	141_E	0.600	0.31
85_K	95_N	0.598	0.31
182_Q	187_L	0.598	0.31
68_T	111_K	0.596	0.31
132_L	135_M	0.594	0.31
39_L	121_L	0.593	0.31
22_L	123_N	0.591	0.31
19_I	118_S	0.591	0.31
173_K	178_K	0.589	0.31
142_W	146_D	0.587	0.30
52_V	139_E	0.587	0.30
72_L	104_L	0.584	0.30
106_S	163_K	0.580	0.30
192_P	195_E	0.573	0.29
83_Q	127_Q	0.569	0.29
66_F	115_L	0.568	0.29
1_E	127_Q	0.568	0.29
85_K	89_L	0.567	0.29
189_Y	195_E	0.566	0.29
119_E	131_P	0.566	0.29
47_P	142_W	0.565	0.29
91_K	122_I	0.565	0.29
1_E	8_F	0.562	0.29
160_K	169_L	0.556	0.28
44_L	47_P	0.556	0.28
107_D	111_K	0.556	0.28
183_K	189_Y	0.553	0.28
60_S	191_H	0.550	0.28
11_P	135_M	0.549	0.28
3_N	84_L	0.548	0.28
76_K	88_L	0.547	0.28
14_E	58_D	0.545	0.27
164_E	168_K	0.545	0.27
30_D	34_F	0.542	0.27
48_T	148_E	0.542	0.27
72_L	81_I	0.541	0.27
109_S	113_V	0.537	0.27
171_K	175_K	0.536	0.27
182_Q	185_E	0.535	0.27
31_A	122_I	0.534	0.27
123_N	132_L	0.533	0.27
9_F	118_S	0.532	0.27
14_E	38_E	0.532	0.27
179_K	183_K	0.529	0.26
157_I	166_E	0.528	0.26
133_Y	156_L	0.528	0.26
79_P	107_D	0.527	0.26
180_K	183_K	0.527	0.26
94_K	151_K	0.526	0.26
160_K	196_I	0.526	0.26
68_T	188_F	0.524	0.26
175_K	181_A	0.523	0.26
124_M	129_V	0.517	0.26
25_Q	56_D	0.516	0.25
18_G	88_L	0.513	0.25
105_L	141_E	0.511	0.25
41_D	139_E	0.510	0.25
56_D	59_E	0.509	0.25
139_E	156_L	0.504	0.25
58_D	142_W	0.504	0.25
23_L	36_L	0.503	0.25
144_V	151_K	0.502	0.25
171_K	184_E	0.501	0.25
122_I	135_M	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1s3zA	2	0.6142	26.2	0.945	Contact Map
3fgxA	2	0.3299	21	0.947	Contact Map
3t90A	2	0.6244	18.8	0.949	Contact Map
3fynA	2	0.6497	16.5	0.95	Contact Map
3i3gA	2	0.6142	10.1	0.954	Contact Map
3fmtA	2	0.5025	9.3	0.955	Contact Map
2dxqA	2	0.6345	8.5	0.956	Contact Map
2xs6A	2	0.6041	6.7	0.958	Contact Map
1qsmA	3	0.6294	6.6	0.958	Contact Map
4js0B	1	0.1218	6	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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