GREMLIN Database
BCIP - p21-C-terminal region-binding protein
PFAM: PF13862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 197 (197)
Sequences: 654 (493)
Seq/√Len: 35.1
META: 0.191

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_F37_S6.6491.00
66_F117_L5.1501.00
35_D38_E4.8551.00
10_D142_W4.5711.00
16_F20_K3.7031.00
43_I68_T3.4041.00
8_F51_S3.2981.00
118_S133_Y2.9311.00
12_N58_D2.7541.00
69_V114_G2.7271.00
15_D54_K2.4851.00
80_C83_Q2.4091.00
76_K99_A2.3841.00
112_P153_T2.3530.99
35_D79_P2.1240.99
46_Q50_G1.9610.98
88_L156_L1.9400.98
13_P44_L1.8970.98
191_H194_D1.8840.97
67_L133_Y1.8820.97
116_L157_I1.8370.97
10_D49_V1.8310.97
170_K177_K1.7550.96
37_S41_D1.7490.96
18_G153_T1.7300.96
17_H37_S1.7260.96
27_F158_I1.7010.95
171_K177_K1.6730.95
79_P83_Q1.6580.95
49_V143_A1.6420.94
137_L155_Y1.6230.94
177_K180_K1.6030.93
170_K173_K1.5770.93
19_I40_A1.5210.92
11_P53_V1.4470.89
20_K41_D1.4420.89
67_L129_V1.4360.89
114_G152_F1.4260.89
21_T168_K1.4120.88
129_V142_W1.4110.88
134_K138_E1.4100.88
36_L88_L1.3970.88
20_K44_L1.3950.88
107_D110_S1.3650.86
176_K179_K1.3400.85
69_V116_L1.3390.85
16_F41_D1.3190.84
40_A44_L1.3130.84
13_P47_P1.2760.82
18_G126_P1.2630.82
138_E146_D1.2600.82
57_G191_H1.2570.81
23_L117_L1.2440.81
104_L113_V1.2360.80
9_F15_D1.2010.78
72_L89_L1.1990.78
138_E142_W1.1950.78
11_P142_W1.1930.78
45_S93_E1.1910.78
25_Q119_E1.1820.77
83_Q86_E1.1700.76
11_P69_V1.1610.76
9_F130_P1.1490.75
170_K174_K1.1400.74
3_N138_E1.1360.74
173_K180_K1.1210.73
35_D83_Q1.1170.73
57_G60_S1.1060.72
186_E189_Y1.1040.72
37_S155_Y1.0920.71
176_K183_K1.0820.71
34_F87_Y1.0710.70
172_K177_K1.0700.70
19_I113_V1.0690.70
142_W145_E1.0670.69
42_L45_S1.0650.69
73_T76_K1.0630.69
171_K178_K1.0600.69
105_L145_E1.0560.69
171_K174_K1.0440.68
175_K179_K1.0400.67
121_L124_M1.0400.67
128_I190_F1.0310.67
53_V128_I1.0300.67
159_S194_D1.0260.66
71_N150_Y1.0240.66
119_E129_V1.0230.66
107_D176_K1.0210.66
144_V150_Y1.0160.66
17_H41_D1.0100.65
38_E78_K1.0080.65
8_F28_F1.0040.65
42_L75_H1.0040.65
124_M135_M1.0030.65
104_L154_H0.9980.64
40_A103_K0.9960.64
13_P175_K0.9880.63
119_E124_M0.9860.63
21_T118_S0.9850.63
25_Q34_F0.9830.63
24_Q28_F0.9820.63
114_G150_Y0.9820.63
36_L187_L0.9710.62
176_K180_K0.9600.61
35_D160_K0.9590.61
189_Y194_D0.9370.59
43_I136_L0.9260.58
135_M149_P0.9250.58
50_G120_R0.9170.58
147_N151_K0.9150.57
46_Q142_W0.9130.57
47_P53_V0.9120.57
116_L155_Y0.9110.57
185_E188_F0.9080.57
140_I146_D0.9050.57
1_E128_I0.9030.56
31_A121_L0.9030.56
55_V129_V0.8920.55
173_K179_K0.8910.55
143_A149_P0.8860.55
38_E79_P0.8850.55
95_N98_L0.8780.54
8_F18_G0.8640.53
55_V60_S0.8630.53
177_K183_K0.8610.53
130_P194_D0.8600.53
65_A162_Y0.8550.52
40_A184_E0.8530.52
113_V154_H0.8500.52
174_K177_K0.8480.52
69_V155_Y0.8470.52
19_I66_F0.8450.51
86_E93_E0.8440.51
178_K181_A0.8420.51
141_E147_N0.8400.51
164_E188_F0.8360.51
38_E121_L0.8340.50
54_K139_E0.8340.50
60_S134_K0.8320.50
68_T116_L0.8320.50
143_A152_F0.8310.50
7_E56_D0.8280.50
8_F129_V0.8130.49
66_F118_S0.8060.48
26_L65_A0.8010.48
188_F197_F0.7920.47
55_V121_L0.7910.47
168_K186_E0.7910.47
158_I163_K0.7850.46
103_K107_D0.7790.46
139_E149_P0.7780.46
18_G28_F0.7760.46
72_L84_L0.7750.45
173_K177_K0.7740.45
17_H20_K0.7740.45
20_K37_S0.7700.45
49_V142_W0.7680.45
115_L156_L0.7640.44
10_D51_S0.7620.44
50_G105_L0.7620.44
111_K153_T0.7610.44
44_L139_E0.7610.44
36_L40_A0.7610.44
30_D115_L0.7580.44
37_S189_Y0.7520.43
124_M190_F0.7510.43
189_Y193_E0.7490.43
19_I107_D0.7460.43
175_K178_K0.7410.43
48_T142_W0.7410.43
180_K184_E0.7360.42
71_N74_E0.7330.42
40_A110_S0.7320.42
11_P19_I0.7310.42
46_Q195_E0.7240.41
137_L144_V0.7180.41
183_K186_E0.7150.40
48_T146_D0.7150.40
53_V148_E0.7100.40
15_D131_P0.7090.40
2_V5_D0.7080.40
40_A136_L0.7010.39
46_Q113_V0.6990.39
74_E78_K0.6980.39
54_K162_Y0.6930.39
18_G52_V0.6910.38
42_L157_I0.6800.38
173_K176_K0.6770.37
19_I59_E0.6770.37
43_I59_E0.6760.37
61_D116_L0.6760.37
34_F43_I0.6740.37
54_K69_V0.6730.37
64_Y194_D0.6710.37
70_L101_L0.6700.37
72_L90_S0.6690.37
25_Q31_A0.6690.37
13_P71_N0.6660.36
135_M139_E0.6620.36
15_D139_E0.6570.36
101_L138_E0.6540.35
11_P43_I0.6500.35
8_F160_K0.6460.35
146_D155_Y0.6450.35
21_T189_Y0.6440.35
11_P46_Q0.6430.35
48_T145_E0.6430.35
67_L157_I0.6390.34
71_N114_G0.6390.34
87_Y190_F0.6380.34
9_F13_P0.6380.34
51_S139_E0.6330.34
169_L177_K0.6330.34
74_E112_P0.6320.34
30_D87_Y0.6310.34
86_E163_K0.6280.33
174_K181_A0.6270.33
172_K175_K0.6260.33
26_L159_S0.6250.33
83_Q163_K0.6250.33
90_S93_E0.6220.33
23_L131_P0.6200.33
47_P143_A0.6190.33
109_S197_F0.6180.33
160_K188_F0.6160.33
46_Q140_I0.6140.32
69_V136_L0.6130.32
68_T195_E0.6130.32
34_F117_L0.6100.32
23_L50_G0.6080.32
139_E155_Y0.6060.32
159_S192_P0.6020.31
2_V141_E0.6000.31
85_K95_N0.5980.31
182_Q187_L0.5980.31
68_T111_K0.5960.31
132_L135_M0.5940.31
39_L121_L0.5930.31
22_L123_N0.5910.31
19_I118_S0.5910.31
173_K178_K0.5890.31
142_W146_D0.5870.30
52_V139_E0.5870.30
72_L104_L0.5840.30
106_S163_K0.5800.30
192_P195_E0.5730.29
83_Q127_Q0.5690.29
66_F115_L0.5680.29
1_E127_Q0.5680.29
85_K89_L0.5670.29
189_Y195_E0.5660.29
119_E131_P0.5660.29
47_P142_W0.5650.29
91_K122_I0.5650.29
1_E8_F0.5620.29
160_K169_L0.5560.28
44_L47_P0.5560.28
107_D111_K0.5560.28
183_K189_Y0.5530.28
60_S191_H0.5500.28
11_P135_M0.5490.28
3_N84_L0.5480.28
76_K88_L0.5470.28
14_E58_D0.5450.27
164_E168_K0.5450.27
30_D34_F0.5420.27
48_T148_E0.5420.27
72_L81_I0.5410.27
109_S113_V0.5370.27
171_K175_K0.5360.27
182_Q185_E0.5350.27
31_A122_I0.5340.27
123_N132_L0.5330.27
9_F118_S0.5320.27
14_E38_E0.5320.27
179_K183_K0.5290.26
157_I166_E0.5280.26
133_Y156_L0.5280.26
79_P107_D0.5270.26
180_K183_K0.5270.26
94_K151_K0.5260.26
160_K196_I0.5260.26
68_T188_F0.5240.26
175_K181_A0.5230.26
124_M129_V0.5170.26
25_Q56_D0.5160.25
18_G88_L0.5130.25
105_L141_E0.5110.25
41_D139_E0.5100.25
56_D59_E0.5090.25
139_E156_L0.5040.25
58_D142_W0.5040.25
23_L36_L0.5030.25
144_V151_K0.5020.25
171_K184_E0.5010.25
122_I135_M0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s3zA 2 0.6142 26.2 0.945 Contact Map
3fgxA 2 0.3299 21 0.947 Contact Map
3t90A 2 0.6244 18.8 0.949 Contact Map
3fynA 2 0.6497 16.5 0.95 Contact Map
3i3gA 2 0.6142 10.1 0.954 Contact Map
3fmtA 2 0.5025 9.3 0.955 Contact Map
2dxqA 2 0.6345 8.5 0.956 Contact Map
2xs6A 2 0.6041 6.7 0.958 Contact Map
1qsmA 3 0.6294 6.6 0.958 Contact Map
4js0B 1 0.1218 6 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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