Septum_form - PFAM28P - GREMLIN Contacts

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Septum_form - Septum formation

PFAM:	PF13845	Sequences: AGDCLTWTFADDASDYEPVDCAQPHRFETAAVVDVGTFPGAEAGPDAPPPDGSRARRLAYERCDPAVREYLGGDWDPNGRLSVGVLLPSEAAWAAGARWFRCDLQETGPDGALVPRTGSLAGALQSDVPLAGTCLGIDPDGNLPTDPVDCAAPHAAEVVGVVDLPDKFPDAYPSEDAQDAFLKDGCTKAAAAYLGGPDDLRYRTLTVFWPTISEESWKAGSRGVRC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	226 (224)
Sequences:	1230 (915)
Seq/√Len:	61.1
META:	0.576

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_A	67_V	4.410	1.00
93_W	98_R	3.872	1.00
174_S	177_A	3.829	1.00
22_A	118_G	3.510	1.00
214_E	218_K	3.486	1.00
62_R	100_F	3.413	1.00
159_V	190_A	3.306	1.00
29_T	103_D	2.956	1.00
29_T	101_R	2.948	1.00
106_E	116_R	2.821	1.00
126_S	221_S	2.583	1.00
185_G	189_A	2.555	1.00
5_L	29_T	2.547	1.00
31_A	66_A	2.540	1.00
90_E	94_A	2.488	1.00
212_I	222_R	2.416	1.00
159_V	189_A	2.413	1.00
216_S	221_S	2.304	1.00
50_P	93_W	2.189	1.00
113_L	116_R	2.166	1.00
28_E	157_E	2.160	1.00
32_V	35_V	2.135	1.00
20_D	118_G	2.127	1.00
28_E	70_Y	2.120	1.00
5_L	14_S	2.105	1.00
160_G	189_A	2.082	1.00
221_S	225_R	2.077	1.00
174_S	178_Q	2.025	1.00
81_L	116_R	2.024	1.00
21_C	25_H	2.007	1.00
25_H	28_E	1.975	1.00
71_L	81_L	1.937	1.00
220_G	226_C	1.909	1.00
78_N	158_V	1.880	1.00
80_R	106_E	1.867	1.00
198_D	202_Y	1.836	1.00
67_V	104_L	1.814	1.00
24_P	115_P	1.802	1.00
119_S	122_G	1.759	0.99
28_E	93_W	1.753	0.99
30_A	70_Y	1.735	0.99
27_F	103_D	1.673	0.99
202_Y	205_L	1.655	0.99
66_A	69_E	1.634	0.99
49_P	52_G	1.609	0.99
177_A	180_A	1.581	0.99
39_P	42_E	1.577	0.99
40_G	43_A	1.546	0.99
33_V	100_F	1.505	0.98
205_L	210_P	1.505	0.98
5_L	103_D	1.468	0.98
31_A	100_F	1.458	0.98
50_P	55_A	1.455	0.98
154_H	157_E	1.401	0.97
104_L	125_Q	1.399	0.97
136_G	155_A	1.357	0.97
76_D	162_V	1.348	0.96
9_F	14_S	1.337	0.96
81_L	123_A	1.329	0.96
192_A	197_P	1.327	0.96
169_P	188_K	1.326	0.96
157_E	193_Y	1.325	0.96
47_A	50_P	1.324	0.96
76_D	79_G	1.309	0.96
185_G	188_K	1.305	0.96
97_A	103_D	1.303	0.96
212_I	216_S	1.290	0.95
148_V	152_A	1.276	0.95
86_L	103_D	1.243	0.94
67_V	71_L	1.240	0.94
139_P	143_L	1.228	0.94
116_R	123_A	1.224	0.94
67_V	83_V	1.214	0.94
5_L	16_Y	1.201	0.93
22_A	112_A	1.200	0.93
4_C	21_C	1.195	0.93
70_Y	195_G	1.193	0.93
71_L	125_Q	1.189	0.93
54_R	58_L	1.182	0.93
81_L	124_L	1.177	0.93
92_A	99_W	1.140	0.91
33_V	36_G	1.132	0.91
152_A	176_D	1.131	0.91
57_R	187_T	1.108	0.90
77_P	80_R	1.102	0.90
100_F	124_L	1.090	0.90
189_A	197_P	1.074	0.89
73_G	79_G	1.073	0.89
116_R	120_L	1.072	0.89
148_V	154_H	1.069	0.89
54_R	57_R	1.064	0.88
102_C	150_C	1.063	0.88
172_Y	214_E	1.039	0.87
35_V	198_D	1.039	0.87
70_Y	157_E	1.038	0.87
112_A	115_P	1.036	0.87
128_V	132_G	1.035	0.87
189_A	192_A	1.033	0.87
56_R	82_S	1.026	0.86
92_A	97_A	1.025	0.86
30_A	66_A	1.017	0.86
91_A	170_D	1.016	0.86
21_C	102_C	1.006	0.85
122_G	125_Q	1.005	0.85
81_L	132_G	1.004	0.85
50_P	178_Q	0.996	0.85
102_C	186_C	0.986	0.84
2_G	21_C	0.984	0.84
78_N	83_V	0.981	0.84
63_C	102_C	0.964	0.83
188_K	192_A	0.963	0.83
47_A	108_G	0.955	0.82
222_R	226_C	0.953	0.82
165_P	222_R	0.952	0.82
191_A	197_P	0.948	0.82
13_A	16_Y	0.946	0.82
149_D	165_P	0.941	0.81
13_A	89_S	0.929	0.80
92_A	197_P	0.928	0.80
28_E	119_S	0.924	0.80
8_T	11_D	0.920	0.80
21_C	150_C	0.917	0.80
89_S	92_A	0.905	0.79
159_V	193_Y	0.903	0.79
150_C	186_C	0.900	0.78
99_W	103_D	0.892	0.78
182_L	209_W	0.888	0.77
63_C	150_C	0.884	0.77
80_R	156_A	0.883	0.77
12_D	151_A	0.878	0.77
38_F	41_A	0.874	0.76
97_A	101_R	0.874	0.76
135_L	158_V	0.866	0.76
78_N	160_G	0.858	0.75
85_V	156_A	0.858	0.75
70_Y	137_I	0.857	0.75
128_V	131_A	0.853	0.74
213_S	224_V	0.836	0.73
163_D	166_D	0.833	0.73
24_P	184_D	0.828	0.72
177_A	214_E	0.825	0.72
30_A	104_L	0.824	0.72
39_P	43_A	0.823	0.72
175_E	178_Q	0.820	0.71
153_P	170_D	0.819	0.71
160_G	185_G	0.818	0.71
104_L	131_A	0.818	0.71
75_W	78_N	0.818	0.71
102_C	134_C	0.814	0.71
208_F	211_T	0.811	0.71
167_K	177_A	0.811	0.71
21_C	134_C	0.810	0.71
50_P	58_L	0.809	0.70
145_T	180_A	0.806	0.70
197_P	202_Y	0.806	0.70
137_I	155_A	0.804	0.70
206_T	224_V	0.801	0.70
63_C	186_C	0.795	0.69
197_P	209_W	0.794	0.69
215_E	218_K	0.789	0.69
32_V	36_G	0.784	0.68
93_W	96_G	0.784	0.68
142_N	218_K	0.783	0.68
21_C	186_C	0.782	0.68
200_L	203_R	0.775	0.67
21_C	63_C	0.775	0.67
89_S	101_R	0.774	0.67
42_E	54_R	0.773	0.67
72_G	154_H	0.771	0.67
217_W	226_C	0.770	0.67
81_L	110_D	0.769	0.67
154_H	160_G	0.767	0.66
221_S	224_V	0.764	0.66
203_R	210_P	0.762	0.66
84_G	115_P	0.749	0.65
172_Y	193_Y	0.747	0.64
59_A	85_V	0.742	0.64
19_V	188_K	0.740	0.64
186_C	226_C	0.737	0.63
81_L	120_L	0.737	0.63
134_C	150_C	0.730	0.63
27_F	124_L	0.728	0.62
205_L	221_S	0.726	0.62
8_T	13_A	0.724	0.62
162_V	185_G	0.720	0.61
199_D	202_Y	0.720	0.61
96_G	99_W	0.717	0.61
210_P	216_S	0.717	0.61
6_T	9_F	0.717	0.61
194_L	203_R	0.716	0.61
167_K	181_F	0.715	0.61
194_L	199_D	0.710	0.60
2_G	63_C	0.709	0.60
9_F	13_A	0.708	0.60
173_P	209_W	0.705	0.60
64_D	68_R	0.699	0.59
28_E	118_G	0.696	0.59
5_L	18_P	0.695	0.59
51_D	153_P	0.693	0.58
77_P	132_G	0.690	0.58
40_G	44_G	0.689	0.58
195_G	209_W	0.686	0.58
83_V	92_A	0.683	0.57
189_A	222_R	0.682	0.57
3_D	18_P	0.681	0.57
8_T	22_A	0.680	0.57
135_L	147_P	0.678	0.57
152_A	172_Y	0.675	0.57
211_T	224_V	0.672	0.56
141_G	144_P	0.672	0.56
79_G	130_L	0.671	0.56
132_G	154_H	0.670	0.56
96_G	103_D	0.670	0.56
88_P	186_C	0.668	0.56
75_W	158_V	0.666	0.55
41_A	44_G	0.663	0.55
87_L	136_G	0.659	0.55
142_N	152_A	0.658	0.55
51_D	192_A	0.656	0.54
11_D	180_A	0.656	0.54
42_E	45_P	0.653	0.54
24_P	61_E	0.653	0.54
67_V	160_G	0.651	0.54
126_S	153_P	0.648	0.53
70_Y	118_G	0.647	0.53
31_A	86_L	0.646	0.53
59_A	101_R	0.644	0.53
27_F	101_R	0.638	0.52
29_T	131_A	0.637	0.52
104_L	161_V	0.636	0.52
82_S	179_D	0.636	0.52
75_W	79_G	0.635	0.52
212_I	223_G	0.635	0.52
158_V	161_V	0.633	0.52
94_A	192_A	0.632	0.52
110_D	114_V	0.631	0.52
56_R	61_E	0.627	0.51
4_C	63_C	0.626	0.51
7_W	26_R	0.625	0.51
113_L	117_T	0.624	0.51
73_G	126_S	0.620	0.50
134_C	186_C	0.620	0.50
133_T	160_G	0.619	0.50
63_C	134_C	0.618	0.50
203_R	223_G	0.613	0.50
84_G	92_A	0.612	0.49
27_F	79_G	0.609	0.49
135_L	145_T	0.607	0.49
70_Y	205_L	0.601	0.48
116_R	119_S	0.600	0.48
125_Q	195_G	0.597	0.48
35_V	38_F	0.592	0.47
29_T	100_F	0.591	0.47
148_V	151_A	0.587	0.47
90_E	214_E	0.587	0.47
79_G	125_Q	0.583	0.46
81_L	106_E	0.583	0.46
65_P	143_L	0.583	0.46
28_E	154_H	0.581	0.46
114_V	117_T	0.580	0.46
202_Y	208_F	0.579	0.46
24_P	117_T	0.579	0.46
191_A	198_D	0.578	0.46
149_D	207_V	0.578	0.46
48_P	52_G	0.577	0.45
195_G	203_R	0.577	0.45
162_V	219_A	0.576	0.45
176_D	190_A	0.571	0.45
172_Y	224_V	0.571	0.45
21_C	28_E	0.571	0.45
76_D	158_V	0.570	0.45
120_L	123_A	0.569	0.45
41_A	152_A	0.566	0.44
103_D	190_A	0.565	0.44
93_W	149_D	0.564	0.44
197_P	201_R	0.562	0.44
69_E	198_D	0.562	0.44
60_Y	158_V	0.561	0.44
77_P	221_S	0.560	0.44
39_P	141_G	0.560	0.44
15_D	208_F	0.559	0.43
27_F	111_G	0.558	0.43
179_D	182_L	0.556	0.43
7_W	27_F	0.553	0.43
164_L	178_Q	0.552	0.43
124_L	127_D	0.551	0.43
186_C	217_W	0.550	0.42
132_G	162_V	0.549	0.42
65_P	91_A	0.549	0.42
150_C	226_C	0.548	0.42
52_G	57_R	0.544	0.42
94_A	106_E	0.543	0.42
171_A	177_A	0.542	0.42
17_E	24_P	0.537	0.41
153_P	213_S	0.537	0.41
69_E	153_P	0.535	0.41
4_C	25_H	0.534	0.41
190_A	202_Y	0.532	0.40
134_C	226_C	0.529	0.40
206_T	210_P	0.528	0.40
123_A	190_A	0.527	0.40
3_D	7_W	0.527	0.40
7_W	103_D	0.526	0.40
161_V	223_G	0.524	0.40
65_P	69_E	0.523	0.39
35_V	54_R	0.523	0.39
4_C	102_C	0.522	0.39
8_T	16_Y	0.521	0.39
106_E	114_V	0.521	0.39
12_D	15_D	0.521	0.39
213_S	223_G	0.521	0.39
207_V	219_A	0.520	0.39
68_R	183_K	0.517	0.39
124_L	129_P	0.517	0.39
69_E	72_G	0.517	0.39
161_V	169_P	0.517	0.39
49_P	93_W	0.516	0.39
179_D	183_K	0.516	0.39
73_G	124_L	0.515	0.39
17_E	95_A	0.515	0.39
26_R	67_V	0.515	0.39
116_R	160_G	0.515	0.39
76_D	80_R	0.515	0.39
64_D	182_L	0.511	0.38
126_S	163_D	0.509	0.38
53_S	94_A	0.508	0.38
217_W	220_G	0.508	0.38
68_R	188_K	0.508	0.38
48_P	214_E	0.507	0.38
130_L	133_T	0.506	0.38
49_P	55_A	0.505	0.38
22_A	138_D	0.505	0.38
205_L	209_W	0.504	0.37
87_L	182_L	0.502	0.37
96_G	101_R	0.502	0.37
53_S	95_A	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1whqA	1	0.4292	3	0.958	Contact Map
2mnjA	1	0.1018	1.2	0.966	Contact Map
1ehsA	1	0.0708	1.2	0.966	Contact Map
1g12A	1	0.3319	1.2	0.967	Contact Map
2jg5A	1	0.2655	1	0.968	Contact Map
4wjmA	2	0.2655	1	0.968	Contact Map
2abqA	2	0.2655	0.9	0.969	Contact Map
4a1sC	1	0.0973	0.6	0.973	Contact Map
2zb6A	2	0.1814	0.6	0.973	Contact Map
2qzbA	1	0.2257	0.6	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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