GREMLIN Database
Septum_form - Septum formation
PFAM: PF13845 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 226 (224)
Sequences: 1230 (915)
Seq/√Len: 61.1
META: 0.576

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_A67_V4.4101.00
93_W98_R3.8721.00
174_S177_A3.8291.00
22_A118_G3.5101.00
214_E218_K3.4861.00
62_R100_F3.4131.00
159_V190_A3.3061.00
29_T103_D2.9561.00
29_T101_R2.9481.00
106_E116_R2.8211.00
126_S221_S2.5831.00
185_G189_A2.5551.00
5_L29_T2.5471.00
31_A66_A2.5401.00
90_E94_A2.4881.00
212_I222_R2.4161.00
159_V189_A2.4131.00
216_S221_S2.3041.00
50_P93_W2.1891.00
113_L116_R2.1661.00
28_E157_E2.1601.00
32_V35_V2.1351.00
20_D118_G2.1271.00
28_E70_Y2.1201.00
5_L14_S2.1051.00
160_G189_A2.0821.00
221_S225_R2.0771.00
174_S178_Q2.0251.00
81_L116_R2.0241.00
21_C25_H2.0071.00
25_H28_E1.9751.00
71_L81_L1.9371.00
220_G226_C1.9091.00
78_N158_V1.8801.00
80_R106_E1.8671.00
198_D202_Y1.8361.00
67_V104_L1.8141.00
24_P115_P1.8021.00
119_S122_G1.7590.99
28_E93_W1.7530.99
30_A70_Y1.7350.99
27_F103_D1.6730.99
202_Y205_L1.6550.99
66_A69_E1.6340.99
49_P52_G1.6090.99
177_A180_A1.5810.99
39_P42_E1.5770.99
40_G43_A1.5460.99
33_V100_F1.5050.98
205_L210_P1.5050.98
5_L103_D1.4680.98
31_A100_F1.4580.98
50_P55_A1.4550.98
154_H157_E1.4010.97
104_L125_Q1.3990.97
136_G155_A1.3570.97
76_D162_V1.3480.96
9_F14_S1.3370.96
81_L123_A1.3290.96
192_A197_P1.3270.96
169_P188_K1.3260.96
157_E193_Y1.3250.96
47_A50_P1.3240.96
76_D79_G1.3090.96
185_G188_K1.3050.96
97_A103_D1.3030.96
212_I216_S1.2900.95
148_V152_A1.2760.95
86_L103_D1.2430.94
67_V71_L1.2400.94
139_P143_L1.2280.94
116_R123_A1.2240.94
67_V83_V1.2140.94
5_L16_Y1.2010.93
22_A112_A1.2000.93
4_C21_C1.1950.93
70_Y195_G1.1930.93
71_L125_Q1.1890.93
54_R58_L1.1820.93
81_L124_L1.1770.93
92_A99_W1.1400.91
33_V36_G1.1320.91
152_A176_D1.1310.91
57_R187_T1.1080.90
77_P80_R1.1020.90
100_F124_L1.0900.90
189_A197_P1.0740.89
73_G79_G1.0730.89
116_R120_L1.0720.89
148_V154_H1.0690.89
54_R57_R1.0640.88
102_C150_C1.0630.88
172_Y214_E1.0390.87
35_V198_D1.0390.87
70_Y157_E1.0380.87
112_A115_P1.0360.87
128_V132_G1.0350.87
189_A192_A1.0330.87
56_R82_S1.0260.86
92_A97_A1.0250.86
30_A66_A1.0170.86
91_A170_D1.0160.86
21_C102_C1.0060.85
122_G125_Q1.0050.85
81_L132_G1.0040.85
50_P178_Q0.9960.85
102_C186_C0.9860.84
2_G21_C0.9840.84
78_N83_V0.9810.84
63_C102_C0.9640.83
188_K192_A0.9630.83
47_A108_G0.9550.82
222_R226_C0.9530.82
165_P222_R0.9520.82
191_A197_P0.9480.82
13_A16_Y0.9460.82
149_D165_P0.9410.81
13_A89_S0.9290.80
92_A197_P0.9280.80
28_E119_S0.9240.80
8_T11_D0.9200.80
21_C150_C0.9170.80
89_S92_A0.9050.79
159_V193_Y0.9030.79
150_C186_C0.9000.78
99_W103_D0.8920.78
182_L209_W0.8880.77
63_C150_C0.8840.77
80_R156_A0.8830.77
12_D151_A0.8780.77
38_F41_A0.8740.76
97_A101_R0.8740.76
135_L158_V0.8660.76
78_N160_G0.8580.75
85_V156_A0.8580.75
70_Y137_I0.8570.75
128_V131_A0.8530.74
213_S224_V0.8360.73
163_D166_D0.8330.73
24_P184_D0.8280.72
177_A214_E0.8250.72
30_A104_L0.8240.72
39_P43_A0.8230.72
175_E178_Q0.8200.71
153_P170_D0.8190.71
160_G185_G0.8180.71
104_L131_A0.8180.71
75_W78_N0.8180.71
102_C134_C0.8140.71
208_F211_T0.8110.71
167_K177_A0.8110.71
21_C134_C0.8100.71
50_P58_L0.8090.70
145_T180_A0.8060.70
197_P202_Y0.8060.70
137_I155_A0.8040.70
206_T224_V0.8010.70
63_C186_C0.7950.69
197_P209_W0.7940.69
215_E218_K0.7890.69
32_V36_G0.7840.68
93_W96_G0.7840.68
142_N218_K0.7830.68
21_C186_C0.7820.68
200_L203_R0.7750.67
21_C63_C0.7750.67
89_S101_R0.7740.67
42_E54_R0.7730.67
72_G154_H0.7710.67
217_W226_C0.7700.67
81_L110_D0.7690.67
154_H160_G0.7670.66
221_S224_V0.7640.66
203_R210_P0.7620.66
84_G115_P0.7490.65
172_Y193_Y0.7470.64
59_A85_V0.7420.64
19_V188_K0.7400.64
186_C226_C0.7370.63
81_L120_L0.7370.63
134_C150_C0.7300.63
27_F124_L0.7280.62
205_L221_S0.7260.62
8_T13_A0.7240.62
162_V185_G0.7200.61
199_D202_Y0.7200.61
96_G99_W0.7170.61
210_P216_S0.7170.61
6_T9_F0.7170.61
194_L203_R0.7160.61
167_K181_F0.7150.61
194_L199_D0.7100.60
2_G63_C0.7090.60
9_F13_A0.7080.60
173_P209_W0.7050.60
64_D68_R0.6990.59
28_E118_G0.6960.59
5_L18_P0.6950.59
51_D153_P0.6930.58
77_P132_G0.6900.58
40_G44_G0.6890.58
195_G209_W0.6860.58
83_V92_A0.6830.57
189_A222_R0.6820.57
3_D18_P0.6810.57
8_T22_A0.6800.57
135_L147_P0.6780.57
152_A172_Y0.6750.57
211_T224_V0.6720.56
141_G144_P0.6720.56
79_G130_L0.6710.56
132_G154_H0.6700.56
96_G103_D0.6700.56
88_P186_C0.6680.56
75_W158_V0.6660.55
41_A44_G0.6630.55
87_L136_G0.6590.55
142_N152_A0.6580.55
51_D192_A0.6560.54
11_D180_A0.6560.54
42_E45_P0.6530.54
24_P61_E0.6530.54
67_V160_G0.6510.54
126_S153_P0.6480.53
70_Y118_G0.6470.53
31_A86_L0.6460.53
59_A101_R0.6440.53
27_F101_R0.6380.52
29_T131_A0.6370.52
104_L161_V0.6360.52
82_S179_D0.6360.52
75_W79_G0.6350.52
212_I223_G0.6350.52
158_V161_V0.6330.52
94_A192_A0.6320.52
110_D114_V0.6310.52
56_R61_E0.6270.51
4_C63_C0.6260.51
7_W26_R0.6250.51
113_L117_T0.6240.51
73_G126_S0.6200.50
134_C186_C0.6200.50
133_T160_G0.6190.50
63_C134_C0.6180.50
203_R223_G0.6130.50
84_G92_A0.6120.49
27_F79_G0.6090.49
135_L145_T0.6070.49
70_Y205_L0.6010.48
116_R119_S0.6000.48
125_Q195_G0.5970.48
35_V38_F0.5920.47
29_T100_F0.5910.47
148_V151_A0.5870.47
90_E214_E0.5870.47
79_G125_Q0.5830.46
81_L106_E0.5830.46
65_P143_L0.5830.46
28_E154_H0.5810.46
114_V117_T0.5800.46
202_Y208_F0.5790.46
24_P117_T0.5790.46
191_A198_D0.5780.46
149_D207_V0.5780.46
48_P52_G0.5770.45
195_G203_R0.5770.45
162_V219_A0.5760.45
176_D190_A0.5710.45
172_Y224_V0.5710.45
21_C28_E0.5710.45
76_D158_V0.5700.45
120_L123_A0.5690.45
41_A152_A0.5660.44
103_D190_A0.5650.44
93_W149_D0.5640.44
197_P201_R0.5620.44
69_E198_D0.5620.44
60_Y158_V0.5610.44
77_P221_S0.5600.44
39_P141_G0.5600.44
15_D208_F0.5590.43
27_F111_G0.5580.43
179_D182_L0.5560.43
7_W27_F0.5530.43
164_L178_Q0.5520.43
124_L127_D0.5510.43
186_C217_W0.5500.42
132_G162_V0.5490.42
65_P91_A0.5490.42
150_C226_C0.5480.42
52_G57_R0.5440.42
94_A106_E0.5430.42
171_A177_A0.5420.42
17_E24_P0.5370.41
153_P213_S0.5370.41
69_E153_P0.5350.41
4_C25_H0.5340.41
190_A202_Y0.5320.40
134_C226_C0.5290.40
206_T210_P0.5280.40
123_A190_A0.5270.40
3_D7_W0.5270.40
7_W103_D0.5260.40
161_V223_G0.5240.40
65_P69_E0.5230.39
35_V54_R0.5230.39
4_C102_C0.5220.39
8_T16_Y0.5210.39
106_E114_V0.5210.39
12_D15_D0.5210.39
213_S223_G0.5210.39
207_V219_A0.5200.39
68_R183_K0.5170.39
124_L129_P0.5170.39
69_E72_G0.5170.39
161_V169_P0.5170.39
49_P93_W0.5160.39
179_D183_K0.5160.39
73_G124_L0.5150.39
17_E95_A0.5150.39
26_R67_V0.5150.39
116_R160_G0.5150.39
76_D80_R0.5150.39
64_D182_L0.5110.38
126_S163_D0.5090.38
53_S94_A0.5080.38
217_W220_G0.5080.38
68_R188_K0.5080.38
48_P214_E0.5070.38
130_L133_T0.5060.38
49_P55_A0.5050.38
22_A138_D0.5050.38
205_L209_W0.5040.37
87_L182_L0.5020.37
96_G101_R0.5020.37
53_S95_A0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1whqA 1 0.4292 3 0.958 Contact Map
2mnjA 1 0.1018 1.2 0.966 Contact Map
1ehsA 1 0.0708 1.2 0.966 Contact Map
1g12A 1 0.3319 1.2 0.967 Contact Map
2jg5A 1 0.2655 1 0.968 Contact Map
4wjmA 2 0.2655 1 0.968 Contact Map
2abqA 2 0.2655 0.9 0.969 Contact Map
4a1sC 1 0.0973 0.6 0.973 Contact Map
2zb6A 2 0.1814 0.6 0.973 Contact Map
2qzbA 1 0.2257 0.6 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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