GREMLIN Database
DDE_Tnp_1_7 - Transposase IS4
PFAM: PF13843 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 350 (346)
Sequences: 2468 (2187)
Seq/√Len: 117.6
META: 0.655

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_D108_R4.5091.00
21_E24_R4.4591.00
35_T85_I4.2861.00
115_N171_N3.9581.00
173_E197_R3.8341.00
221_A231_A3.8141.00
213_N236_R3.6541.00
211_M231_A3.5901.00
39_E81_R3.4171.00
170_Y202_L2.8301.00
46_L77_M2.8271.00
199_T209_V2.7891.00
128_L161_L2.6071.00
59_R83_E2.4591.00
48_I346_V2.4571.00
43_F86_L2.4071.00
7_E41_K2.3621.00
16_E37_V2.3341.00
114_L118_F2.2721.00
135_V158_I2.1841.00
35_T40_L2.1661.00
216_T233_G2.1651.00
196_L223_E2.1631.00
204_G227_K2.1611.00
128_L202_L2.1611.00
169_V316_S2.1291.00
104_L174_V2.0671.00
15_I41_K2.0571.00
50_M61_Y2.0481.00
46_L73_F2.0261.00
11_D117_N2.0141.00
91_F334_Y1.9951.00
119_Q171_N1.9931.00
276_L303_V1.9891.00
211_M221_A1.9201.00
47_L82_F1.9001.00
127_N309_H1.8281.00
281_H305_D1.8141.00
223_E226_K1.8141.00
93_D96_T1.7891.00
19_V40_L1.7811.00
19_V37_V1.7671.00
126_E208_H1.7571.00
251_K254_E1.7501.00
159_W214_F1.7281.00
208_H232_C1.6971.00
18_I40_L1.6941.00
288_R292_R1.6861.00
18_I91_F1.6761.00
163_D166_T1.6751.00
16_E20_E1.6661.00
135_V337_L1.6621.00
216_T277_L1.6361.00
141_L156_I1.6181.00
162_C313_V1.6161.00
203_L229_I1.6151.00
160_V169_V1.6101.00
35_T39_E1.5891.00
103_K142_S1.5881.00
69_G74_S1.5851.00
289_K292_R1.5851.00
221_A279_T1.5841.00
125_G163_D1.5751.00
192_G223_E1.5731.00
15_I19_V1.5721.00
278_S281_H1.5541.00
15_I40_L1.5371.00
6_F10_F1.5361.00
288_R291_R1.5181.00
211_M216_T1.5181.00
53_V70_T1.5111.00
208_H280_A1.5011.00
191_G194_V1.4971.00
15_I37_V1.4891.00
216_T221_A1.4741.00
171_N201_P1.4701.00
18_I89_L1.4661.00
37_V41_K1.4611.00
146_Y153_K1.4541.00
43_F85_I1.4491.00
159_W194_V1.4451.00
221_A277_L1.4281.00
123_T207_H1.4201.00
27_A34_P1.4151.00
134_M152_I1.4051.00
28_Q94_N1.3991.00
26_A32_W1.3901.00
216_T231_A1.3891.00
269_K273_V1.3871.00
114_L345_A1.3751.00
210_Y309_H1.3721.00
29_K88_F1.3681.00
25_Y90_H1.3631.00
159_W215_F1.3621.00
332_K335_K1.3561.00
129_S164_S1.3441.00
122_Y163_D1.3331.00
169_V344_I1.3291.00
127_N210_Y1.3251.00
230_Y280_A1.3221.00
133_S160_V1.3161.00
24_R28_Q1.3051.00
235_V265_A1.2971.00
15_I44_L1.2961.00
115_N172_F1.2881.00
158_I337_L1.2871.00
210_Y232_C1.2841.00
325_I343_D1.2841.00
17_L21_E1.2780.99
301_E305_D1.2760.99
125_G207_H1.2740.99
307_N310_M1.2670.99
276_L302_I1.2670.99
128_L170_Y1.2610.99
146_Y154_F1.2560.99
14_L110_L1.2460.99
19_V35_T1.2450.99
111_L172_F1.2440.99
213_N234_T1.2310.99
12_D41_K1.2120.99
250_L254_E1.2110.99
235_V242_L1.2100.99
199_T203_L1.2060.99
134_M147_I1.1940.99
189_G192_G1.1910.99
108_R112_D1.1890.99
17_L113_H1.1870.99
274_V278_S1.1850.99
162_C169_V1.1820.99
48_I342_L1.1810.99
117_N120_K1.1760.99
129_S312_G1.1730.99
318_Q322_Y1.1720.99
218_P235_V1.1460.99
91_F110_L1.1440.99
55_L70_T1.1360.99
80_N83_E1.1240.99
289_K293_G1.1140.99
138_K154_F1.1130.99
92_S109_P1.1100.99
131_D213_N1.1060.99
90_H94_N1.1040.99
225_L230_Y1.0980.98
222_E260_K1.0940.98
3_L7_E1.0900.98
129_S310_M1.0900.98
90_H106_K1.0870.98
56_P60_D1.0860.98
79_R83_E1.0860.98
42_A76_V1.0840.98
128_L207_H1.0810.98
204_G228_G1.0790.98
92_S105_A1.0790.98
6_F48_I1.0740.98
158_I174_V1.0720.98
288_R293_G1.0710.98
265_A277_L1.0690.98
7_E12_D1.0690.98
116_E120_K1.0610.98
46_L76_V1.0590.98
119_Q201_P1.0480.98
267_K275_L1.0460.98
192_G219_P1.0430.98
192_G196_L1.0400.98
319_L347_V1.0380.98
267_K273_V1.0360.98
45_G76_V1.0350.98
44_L342_L1.0330.98
225_L262_D1.0330.98
264_L302_I1.0320.98
35_T81_R1.0300.98
209_V229_I1.0260.98
60_D63_S1.0260.98
315_R318_Q1.0250.98
14_L113_H1.0240.98
191_G214_F1.0200.98
134_M155_G1.0160.97
266_V302_I1.0100.97
218_P263_L1.0060.97
130_I195_V1.0050.97
191_G215_F1.0050.97
113_H117_N1.0030.97
118_F345_A0.9990.97
145_Q175_Y0.9980.97
124_P170_Y0.9980.97
316_S344_I0.9980.97
290_R293_G0.9950.97
161_L171_N0.9950.97
338_F342_L0.9940.97
84_L87_R0.9930.97
118_F168_Y0.9920.97
21_E94_N0.9850.97
320_R340_H0.9840.97
24_R93_D0.9790.97
125_G166_T0.9780.97
203_L227_K0.9750.97
162_C316_S0.9690.97
222_E263_L0.9600.96
242_L265_A0.9580.96
94_N106_K0.9540.96
127_N208_H0.9510.96
63_S68_L0.9480.96
22_T35_T0.9480.96
224_L231_A0.9480.96
124_P128_L0.9470.96
223_E227_K0.9440.96
49_L73_F0.9430.96
220_L224_L0.9410.96
57_S60_D0.9370.96
205_K229_I0.9200.95
138_K153_K0.9200.95
52_L56_P0.9190.95
188_L192_G0.9160.95
271_K274_V0.9150.95
190_L194_V0.9120.95
147_I153_K0.9110.95
40_L43_F0.9110.95
250_L269_K0.9030.95
114_L341_L0.9020.95
190_L214_F0.8970.95
96_T105_A0.8950.95
193_R197_R0.8820.94
340_H344_I0.8800.94
21_E93_D0.8760.94
232_C280_A0.8760.94
137_F141_L0.8760.94
173_E193_R0.8730.94
164_S312_G0.8730.94
97_R105_A0.8700.94
285_T289_K0.8670.94
285_T292_R0.8650.94
255_S266_V0.8570.93
134_M151_P0.8550.93
300_P303_V0.8550.93
8_L121_L0.8520.93
81_R85_I0.8470.93
208_H230_Y0.8450.93
136_P152_I0.8450.93
40_L44_L0.8430.93
158_I215_F0.8380.93
232_C281_H0.8380.93
29_K87_R0.8340.92
130_I209_V0.8280.92
274_V279_T0.8260.92
316_S320_R0.8250.92
130_I198_L0.8230.92
299_K304_K0.8230.92
346_V349_A0.8200.92
232_C305_D0.8190.92
12_D37_V0.8150.92
130_I161_L0.8150.92
195_V220_L0.8080.91
135_V340_H0.8060.91
307_N314_D0.8020.91
12_D16_E0.8010.91
21_E28_Q0.7990.91
286_V289_K0.7990.91
286_V293_G0.7960.91
146_Y234_T0.7950.91
345_A349_A0.7940.90
147_I155_G0.7910.90
211_M277_L0.7910.90
316_S347_V0.7880.90
310_M314_D0.7820.90
58_L83_E0.7800.90
14_L18_I0.7790.90
26_A88_F0.7770.89
235_V277_L0.7730.89
159_W190_L0.7730.89
188_L196_L0.7690.89
129_S311_G0.7680.89
207_H229_I0.7640.89
210_Y305_D0.7610.89
132_E314_D0.7600.88
169_V348_N0.7600.88
53_V73_F0.7600.88
110_L338_F0.7600.88
84_L88_F0.7590.88
304_K308_K0.7580.88
62_W77_M0.7550.88
25_Y28_Q0.7520.88
159_W175_Y0.7500.88
221_A225_L0.7470.88
92_S97_R0.7460.88
20_E24_R0.7460.88
189_G193_R0.7450.87
314_D317_D0.7430.87
144_K154_F0.7410.87
190_L193_R0.7410.87
25_Y94_N0.7380.87
197_R200_E0.7380.87
143_F156_I0.7370.87
147_I214_F0.7360.87
117_N121_L0.7360.87
44_L338_F0.7350.87
255_S258_R0.7340.87
252_R255_S0.7320.87
21_E90_H0.7310.86
130_I199_T0.7280.86
118_F171_N0.7280.86
275_L278_S0.7250.86
196_L227_K0.7240.86
133_S340_H0.7230.86
324_S327_R0.7230.86
19_V23_N0.7220.86
287_E291_R0.7210.86
167_G315_R0.7200.86
311_G315_R0.7190.86
89_L338_F0.7160.85
131_D314_D0.7160.85
36_T85_I0.7160.85
212_D234_T0.7130.85
28_Q93_D0.7130.85
104_L108_R0.7120.85
106_K334_Y0.7110.85
124_P202_L0.7100.85
118_F348_N0.7090.85
139_G144_K0.7080.85
253_G268_W0.7060.84
69_G75_K0.6990.84
287_E292_R0.6990.84
310_M313_V0.6970.84
42_A45_G0.6960.84
122_Y166_T0.6950.84
234_T314_D0.6950.84
8_L124_P0.6940.83
163_D167_G0.6920.83
17_L20_E0.6920.83
21_E25_Y0.6910.83
138_K146_Y0.6890.83
71_P75_K0.6890.83
25_Y106_K0.6880.83
157_K175_Y0.6830.83
121_L168_Y0.6820.82
12_D19_V0.6800.82
134_M149_N0.6800.82
307_N311_G0.6770.82
257_F264_L0.6770.82
28_Q95_S0.6730.82
259_R264_L0.6720.81
115_N118_F0.6710.81
32_W84_L0.6700.81
244_K247_K0.6690.81
111_L115_N0.6680.81
70_T74_S0.6670.81
188_L193_R0.6670.81
58_L86_L0.6660.81
130_I194_V0.6660.81
219_P241_G0.6650.81
277_L281_H0.6650.81
23_N32_W0.6630.81
91_F338_F0.6630.81
132_E234_T0.6620.81
156_I337_L0.6620.81
210_Y281_H0.6610.80
199_T229_I0.6580.80
212_D314_D0.6580.80
115_N119_Q0.6570.80
11_D14_L0.6560.80
161_L209_V0.6560.80
266_V270_D0.6540.80
18_I338_F0.6540.80
245_E258_R0.6520.80
70_T73_F0.6520.80
268_W274_V0.6510.79
156_I174_V0.6510.79
225_L279_T0.6500.79
159_W191_G0.6500.79
169_V172_F0.6480.79
311_G318_Q0.6480.79
128_L199_T0.6480.79
287_E293_G0.6440.79
59_R79_R0.6440.79
126_E206_G0.6400.78
285_T288_R0.6380.78
132_E150_K0.6370.78
104_L143_F0.6360.78
286_V291_R0.6360.78
222_E226_K0.6350.78
35_T43_F0.6330.77
305_D309_H0.6290.77
310_M317_D0.6290.77
4_D7_E0.6290.77
125_G165_S0.6290.77
312_G323_Y0.6260.77
203_L206_G0.6230.76
131_D212_D0.6210.76
141_L144_K0.6200.76
275_L279_T0.6190.76
109_P112_D0.6190.76
246_L256_D0.6190.76
40_L85_I0.6180.76
33_K36_T0.6170.76
234_T239_R0.6150.75
257_F266_V0.6140.75
286_V290_R0.6130.75
20_E27_A0.6090.75
263_L277_L0.6090.75
26_A84_L0.6060.74
62_W79_R0.6050.74
194_V198_L0.6030.74
124_P207_H0.6030.74
23_N39_E0.6030.74
203_L207_H0.6020.74
328_K331_K0.6010.74
11_D16_E0.6000.74
206_G230_Y0.6000.74
284_E292_R0.5930.73
253_G256_D0.5890.72
11_D113_H0.5880.72
93_D105_A0.5880.72
111_L174_V0.5870.72
10_F15_I0.5860.72
148_P153_K0.5850.72
9_F117_N0.5830.72
325_I342_L0.5820.71
313_V317_D0.5820.71
192_G217_S0.5810.71
131_D234_T0.5800.71
174_V337_L0.5770.71
287_E290_R0.5770.71
274_V281_H0.5760.71
169_V347_V0.5750.71
131_D150_K0.5730.70
112_D116_E0.5730.70
38_E41_K0.5710.70
52_L55_L0.5700.70
339_F343_D0.5680.70
221_A263_L0.5680.70
291_R294_K0.5660.69
270_D274_V0.5650.69
133_S169_V0.5650.69
106_K332_K0.5640.69
324_S343_D0.5640.69
23_N33_K0.5640.69
305_D308_K0.5610.69
56_P70_T0.5610.69
114_L342_L0.5600.69
122_Y170_Y0.5600.69
145_Q157_K0.5570.68
62_W80_N0.5570.68
122_Y125_G0.5570.68
118_F121_L0.5560.68
254_E258_R0.5550.68
51_G323_Y0.5520.67
306_Y310_M0.5520.67
320_R343_D0.5520.67
266_V276_L0.5520.67
326_S336_K0.5510.67
20_E45_G0.5510.67
131_D151_P0.5500.67
171_N202_L0.5500.67
85_I89_L0.5490.67
204_G229_I0.5480.67
143_F215_F0.5470.67
303_V307_N0.5460.67
128_L209_V0.5450.66
218_P242_L0.5450.66
30_R34_P0.5450.66
320_R344_I0.5440.66
24_R94_N0.5440.66
253_G257_F0.5430.66
80_N84_L0.5420.66
285_T290_R0.5420.66
155_G314_D0.5420.66
81_R243_P0.5410.66
335_K339_F0.5390.66
210_Y280_A0.5390.66
134_M157_K0.5390.66
160_V344_I0.5380.65
320_R347_V0.5380.65
316_S340_H0.5350.65
23_N35_T0.5340.65
144_K148_P0.5330.65
131_D155_G0.5330.65
257_F260_K0.5310.64
175_Y213_N0.5310.64
9_F118_F0.5300.64
134_M154_F0.5290.64
200_E203_L0.5290.64
16_E19_V0.5280.64
242_L246_L0.5280.64
252_R256_D0.5270.64
56_P61_Y0.5270.64
19_V85_I0.5270.64
45_G72_F0.5260.64
104_L176_T0.5260.64
14_L117_N0.5250.64
55_L61_Y0.5240.63
151_P312_G0.5220.63
159_W173_E0.5220.63
39_E85_I0.5220.63
196_L203_L0.5210.63
103_K159_W0.5200.63
112_D155_G0.5200.63
217_S239_R0.5190.63
250_L256_D0.5190.63
199_T224_L0.5190.63
274_V277_L0.5180.63
149_N154_F0.5170.62
222_E262_D0.5170.62
278_S302_I0.5160.62
15_I110_L0.5150.62
265_A268_W0.5140.62
306_Y313_V0.5090.61
49_L52_L0.5090.61
146_Y272_K0.5090.61
230_Y281_H0.5090.61
132_E213_N0.5070.61
213_N314_D0.5070.61
107_I172_F0.5060.61
98_P101_Y0.5050.61
103_K179_D0.5040.60
311_G314_D0.5040.60
58_L79_R0.5030.60
145_Q214_F0.5020.60
19_V36_T0.5020.60
72_F76_V0.5010.60
32_W35_T0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.7943 55 0.954 Contact Map
4mq3A 1 0.3629 5.5 0.972 Contact Map
3j25A 1 0.2943 4.8 0.973 Contact Map
3l3uA 2 0.4257 4.6 0.973 Contact Map
4cf8A 2 0.4086 4.3 0.973 Contact Map
2jxcB 1 0.0429 4.1 0.974 Contact Map
1c6vA 4 0.42 3.8 0.974 Contact Map
1cxqA 2 0.4 3.8 0.974 Contact Map
2cqkA 1 0.2886 3.3 0.975 Contact Map
4wv4B 1 0.1857 3.2 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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