GREMLIN Database
DUF4193 - Domain of unknown function (DUF4193)
PFAM: PF13834 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 98 (97)
Sequences: 2280 (1143)
Seq/√Len: 116.0
META: 0.82

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_L66_Q4.1681.00
79_K83_Q3.5531.00
65_K71_T2.8151.00
24_K27_R2.2951.00
88_K91_R2.2711.00
84_L92_M2.2321.00
93_I98_A2.0321.00
21_E24_K2.0041.00
51_A54_S1.9661.00
86_D91_R1.9501.00
61_R71_T1.9091.00
19_S24_K1.8951.00
86_D98_A1.8841.00
74_S93_I1.7741.00
83_Q96_D1.6221.00
5_Y9_R1.5901.00
86_D93_I1.5511.00
86_D89_N1.5121.00
57_E68_D1.4421.00
24_K28_A1.4131.00
68_D80_H1.4041.00
22_E27_R1.3881.00
23_L29_D1.3321.00
27_R31_Q1.3121.00
67_A80_H1.3111.00
20_L26_R1.3061.00
19_S26_R1.2871.00
67_A81_R1.2790.99
17_E20_L1.2620.99
79_K84_L1.2550.99
24_K29_D1.2500.99
22_E25_A1.2430.99
87_E90_G1.2340.99
94_C97_C1.2200.99
47_E51_A1.2100.99
48_L52_D1.1510.99
60_V63_L1.0990.98
87_E92_M1.0940.98
2_A12_D1.0920.98
86_D92_M1.0680.98
62_V66_Q1.0650.98
25_A28_A1.0620.98
29_D32_S1.0610.98
39_E43_A1.0410.98
56_E60_V1.0280.98
15_L18_D1.0160.97
79_K82_S0.9980.97
48_L54_S0.9980.97
48_L51_A0.9920.97
73_S93_I0.9850.97
50_G54_S0.9810.97
26_R29_D0.9810.97
7_A11_T0.9710.97
47_E50_G0.9700.96
86_D95_R0.9660.96
2_A10_K0.9660.96
81_R87_E0.9520.96
85_A88_K0.9510.96
19_S27_R0.9510.96
73_S91_R0.9410.96
85_A95_R0.9350.96
76_F88_K0.9250.95
92_M98_A0.9240.95
58_L82_S0.9210.95
71_T92_M0.9200.95
72_C75_C0.9150.95
27_R30_K0.9090.95
10_K13_D0.8990.95
78_V81_R0.8960.95
88_K92_M0.8940.94
73_S92_M0.8930.94
7_A10_K0.8900.94
89_N92_M0.8750.94
56_E62_V0.8640.93
49_P52_D0.8590.93
69_E75_C0.8590.93
33_A36_D0.8360.92
25_A29_D0.8300.92
50_G55_G0.8020.91
49_P56_E0.8000.90
5_Y8_P0.7800.89
28_A31_Q0.7740.89
3_T8_P0.7710.89
58_L66_Q0.7680.89
35_V49_P0.7650.88
69_E72_C0.7570.88
32_S35_V0.7550.88
84_L87_E0.7500.87
83_Q95_R0.7440.87
11_T14_E0.7340.86
33_A37_E0.7300.86
81_R92_M0.7300.86
87_E91_R0.7270.86
63_L80_H0.7210.85
56_E59_T0.7120.85
23_L28_A0.7090.84
12_D37_E0.7030.84
42_A45_S0.6930.83
51_A55_G0.6920.83
52_D55_G0.6900.83
71_T80_H0.6850.82
21_E27_R0.6850.82
34_V37_E0.6790.82
44_E50_G0.6770.82
79_K93_I0.6750.81
60_V68_D0.6530.79
65_K83_Q0.6520.79
50_G53_L0.6490.79
18_D24_K0.6340.77
47_E52_D0.6300.77
22_E26_R0.6300.77
43_A46_F0.6290.77
68_D81_R0.6220.76
71_T78_V0.6220.76
45_S48_L0.6210.76
17_E26_R0.6200.76
74_S98_A0.6190.75
24_K31_Q0.6100.74
6_D9_R0.6060.74
59_T65_K0.6020.73
38_D41_E0.6000.73
23_L31_Q0.5990.73
23_L47_E0.5940.72
61_R78_V0.5840.71
92_M95_R0.5840.71
47_E54_S0.5820.71
48_L53_L0.5720.70
46_F57_E0.5690.69
67_A73_S0.5660.69
19_S22_E0.5640.69
7_A12_D0.5620.68
52_D56_E0.5590.68
13_D16_D0.5550.67
23_L56_E0.5540.67
3_T7_A0.5490.66
26_R30_K0.5460.66
39_E45_S0.5370.65
37_E42_A0.5350.64
25_A31_Q0.5330.64
2_A13_D0.5180.62
38_D64_P0.5160.62
46_F52_D0.5130.61
74_S78_V0.5060.60
57_E63_L0.5040.60
70_F84_L0.5000.59
91_R95_R0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3na7A 1 0.898 51.8 0.877 Contact Map
4iloA 3 0.898 30.7 0.892 Contact Map
3hctA 1 0.4184 27.1 0.895 Contact Map
3hcsA 2 0.4184 24.9 0.897 Contact Map
4tkpB 1 0.3571 24.7 0.897 Contact Map
2ecvA 1 0.4694 22.4 0.899 Contact Map
4cfgA 2 0 21.7 0.9 Contact Map
4txaA 1 0.3367 21.1 0.9 Contact Map
3h7hA 1 0.3776 20.7 0.9 Contact Map
2ecwA 1 0.4694 19.5 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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