GREMLIN Database
DUF4191 - Domain of unknown function (DUF4191)
PFAM: PF13829 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 219 (215)
Sequences: 2196 (1297)
Seq/√Len: 88.4
META: 0.709

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_I174_H3.6001.00
50_P54_I3.0081.00
162_G165_Q2.8031.00
82_E161_D2.7151.00
37_L61_G2.7031.00
32_A64_A2.5801.00
22_D72_R2.5761.00
155_Y181_N2.5551.00
138_L156_D2.2801.00
42_V46_L2.2421.00
37_L41_V2.2271.00
12_R16_K2.2111.00
20_K80_Q2.1901.00
170_K173_R2.1651.00
31_G35_G2.0631.00
63_L67_I2.0591.00
32_A68_V2.0411.00
127_G134_V2.0201.00
26_G30_L2.0081.00
15_Y19_R1.9981.00
15_Y26_G1.9811.00
40_G57_G1.9741.00
146_A154_I1.9661.00
61_G65_A1.9641.00
117_V124_V1.9091.00
49_H52_Y1.8721.00
33_F61_G1.8711.00
127_G138_L1.8691.00
21_E80_Q1.8641.00
92_L126_V1.8321.00
54_I58_V1.8041.00
29_M65_A1.7891.00
28_L31_G1.7881.00
112_D133_R1.7641.00
41_V45_L1.7151.00
28_L32_A1.6901.00
24_R28_L1.6831.00
123_V145_V1.6811.00
123_V149_A1.6781.00
38_A42_V1.6761.00
16_K20_K1.6741.00
101_V117_V1.6461.00
167_P170_K1.6451.00
14_A73_A1.6251.00
13_Q16_K1.6191.00
142_K156_D1.6091.00
88_A115_H1.6041.00
8_L12_R1.5791.00
89_A103_P1.5551.00
107_A111_Q1.5531.00
36_V64_A1.5441.00
42_V45_L1.5361.00
157_I166_V1.4991.00
138_L158_V1.4710.99
25_L29_M1.4670.99
134_V138_L1.4660.99
131_P158_V1.4620.99
161_D167_P1.4610.99
51_I55_I1.4590.99
27_P30_L1.4590.99
174_H177_K1.4580.99
9_K12_R1.4440.99
19_R26_G1.4340.99
176_M180_R1.4300.99
23_P27_P1.4240.99
35_G42_V1.4070.99
74_Q77_A1.3880.99
127_G158_V1.3780.99
56_L59_L1.3490.99
6_G9_K1.3210.99
36_V40_G1.3180.99
183_T186_E1.3040.99
210_M213_G1.2970.99
24_R27_P1.2910.99
51_I54_I1.2880.99
35_G38_A1.2800.99
155_Y178_L1.2720.98
7_R10_Q1.2240.98
184_K188_T1.2180.98
157_I175_L1.2150.98
37_L58_V1.2100.98
213_G216_M1.1880.98
49_H53_L1.1830.98
166_V171_L1.1810.98
102_T115_H1.1800.98
41_V54_I1.1680.97
92_L175_L1.1660.97
161_D169_R1.1480.97
212_T217_P1.1480.97
100_R191_N1.1300.97
5_P9_K1.1260.97
19_R23_P1.1210.97
130_P133_R1.1170.97
153_P181_N1.1000.96
182_L187_V1.0960.96
5_P8_L1.0860.96
121_P124_V1.0670.95
33_F65_A1.0670.95
37_L40_G1.0610.95
16_K19_R1.0590.95
106_A110_Q1.0560.95
158_V165_Q1.0500.95
75_R169_R1.0420.95
77_A91_V1.0370.95
18_T25_L1.0340.95
18_T22_D1.0280.94
131_P165_Q1.0260.94
108_T112_D1.0220.94
120_R184_K1.0220.94
215_R218_R1.0210.94
81_I90_A1.0190.94
93_Q103_P1.0170.94
52_Y56_L1.0030.94
138_L145_V0.9960.93
32_A36_V0.9930.93
99_W121_P0.9880.93
120_R187_V0.9880.93
52_Y55_I0.9780.93
43_I46_L0.9720.93
15_Y27_P0.9630.92
40_G44_G0.9600.92
18_T29_M0.9560.92
173_R180_R0.9540.92
63_L66_M0.9470.92
73_A77_A0.9460.92
104_A115_H0.9450.92
4_K7_R0.9380.91
209_P213_G0.9230.91
213_G217_P0.9220.91
15_Y29_M0.9170.90
89_A115_H0.9110.90
142_K146_A0.9010.90
60_L64_A0.8970.89
148_V197_L0.8960.89
40_G60_L0.8930.89
39_V60_L0.8880.89
71_R74_Q0.8880.89
130_P134_V0.8740.88
141_E144_R0.8660.88
18_T73_A0.8590.87
139_A142_K0.8550.87
18_T72_R0.8540.87
212_T216_M0.8530.87
64_A68_V0.8520.87
120_R180_R0.8520.87
19_R25_L0.8510.87
140_Q143_K0.8470.86
43_I47_L0.8470.86
34_L37_L0.8420.86
91_V172_Q0.8380.86
24_R72_R0.8360.86
99_W119_G0.8360.86
121_P155_Y0.8220.85
152_V190_V0.8210.85
45_L50_P0.8200.85
127_G130_P0.8180.84
124_V178_L0.8170.84
4_K8_L0.8150.84
70_G74_Q0.8130.84
5_P13_Q0.8100.84
30_L34_L0.8090.84
7_R12_R0.8070.84
209_P212_T0.8070.84
149_A152_V0.8030.83
92_L117_V0.8010.83
18_T168_L0.7990.83
33_F37_L0.7980.83
15_Y25_L0.7940.83
199_G204_P0.7940.83
56_L60_L0.7940.83
186_E189_A0.7940.83
49_H54_I0.7920.83
29_M32_A0.7900.82
39_V43_I0.7870.82
32_A35_G0.7830.82
144_R147_R0.7810.82
126_V171_L0.7760.81
142_K155_Y0.7740.81
188_T192_K0.7740.81
204_P207_K0.7700.81
89_A104_A0.7590.80
182_L190_V0.7540.79
46_L49_H0.7520.79
175_L178_L0.7510.79
64_A67_I0.7450.78
60_L63_L0.7390.78
127_G156_D0.7390.78
101_V126_V0.7380.78
77_A80_Q0.7370.78
203_L207_K0.7270.77
36_V39_V0.7230.76
3_K7_R0.7230.76
81_I87_A0.7230.76
170_K174_H0.7200.76
8_L11_I0.7190.76
37_L54_I0.7180.76
112_D134_V0.7090.75
135_R158_V0.7050.75
21_E76_A0.7000.74
57_G61_G0.7000.74
30_L33_F0.6990.74
90_A94_N0.6970.74
47_L53_L0.6890.73
114_V137_L0.6830.72
121_P178_L0.6820.72
134_V158_V0.6810.72
139_A156_D0.6810.72
36_V60_L0.6770.72
108_T137_L0.6760.71
17_M20_K0.6760.71
10_Q14_A0.6750.71
187_V191_N0.6740.71
32_A65_A0.6730.71
121_P181_N0.6710.71
117_V175_L0.6700.71
45_L54_I0.6690.71
95_L101_V0.6660.70
15_Y18_T0.6610.70
6_G12_R0.6550.69
66_M70_G0.6520.69
182_L192_K0.6500.68
50_P55_I0.6500.68
97_R159_V0.6500.68
172_Q175_L0.6460.68
210_M216_M0.6450.68
212_T218_R0.6440.68
95_L172_Q0.6440.68
149_A189_A0.6440.68
39_V42_V0.6420.68
7_R63_L0.6390.67
88_A159_V0.6380.67
91_V94_N0.6360.67
185_A188_T0.6300.66
68_V72_R0.6300.66
8_L62_L0.6280.66
44_G53_L0.6260.66
149_A190_V0.6190.65
144_R200_G0.6190.65
26_G29_M0.6180.65
135_R139_A0.6170.64
11_I66_M0.6160.64
35_G39_V0.6140.64
94_N172_Q0.6130.64
132_N136_P0.6110.64
214_A217_P0.6100.64
145_V154_I0.6090.63
77_A90_A0.6080.63
120_R183_T0.6070.63
127_G159_V0.6030.63
157_I171_L0.6020.63
50_P58_V0.5980.62
59_L63_L0.5970.62
11_I14_A0.5940.62
144_R201_P0.5940.62
210_M217_P0.5930.61
208_G211_P0.5930.61
202_R207_K0.5900.61
173_R176_M0.5870.61
78_Y186_E0.5860.61
38_A138_L0.5860.61
118_V191_N0.5840.60
169_R173_R0.5820.60
96_R121_P0.5810.60
17_M77_A0.5790.60
18_T21_E0.5780.59
213_G218_R0.5770.59
166_V173_R0.5760.59
9_K13_Q0.5750.59
131_P164_G0.5740.59
95_L117_V0.5730.59
41_V50_P0.5730.59
40_G43_I0.5700.58
209_P216_M0.5700.58
37_L57_G0.5690.58
192_K195_K0.5670.58
12_R19_R0.5650.58
75_R79_A0.5610.57
53_L57_G0.5600.57
100_R123_V0.5600.57
182_L186_E0.5590.57
88_A126_V0.5560.57
161_D165_Q0.5550.56
129_G134_V0.5540.56
157_I178_L0.5540.56
67_I71_R0.5500.56
18_T80_Q0.5460.55
81_I94_N0.5450.55
109_R133_R0.5430.55
131_P135_R0.5410.55
10_Q13_Q0.5380.54
29_M33_F0.5380.54
191_N195_K0.5350.54
155_Y174_H0.5340.54
114_V127_G0.5340.54
4_K9_K0.5320.53
71_R75_R0.5280.53
34_L136_P0.5250.52
160_G165_Q0.5220.52
100_R187_V0.5220.52
200_G212_T0.5190.52
147_R150_G0.5170.51
139_A149_A0.5170.51
37_L45_L0.5170.51
172_Q176_M0.5160.51
145_V149_A0.5140.51
123_V158_V0.5140.51
173_R203_L0.5140.51
22_D28_L0.5130.51
76_A79_A0.5120.51
33_F39_V0.5120.51
22_D68_V0.5120.51
3_K9_K0.5110.50
23_P26_G0.5110.50
5_P10_Q0.5110.50
67_I157_I0.5080.50
18_T77_A0.5070.50
25_L72_R0.5060.50
91_V159_V0.5050.50
101_V121_P0.5040.50
32_A60_L0.5020.49
21_E24_R0.5010.49
189_A196_A0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m8rA 1 0.2192 63.8 0.953 Contact Map
2mofA 1 0.1918 37.3 0.96 Contact Map
4w252 1 0.2648 12.2 0.968 Contact Map
2akfA 3 0.137 10.5 0.969 Contact Map
2ww9B 1 0.2557 10.4 0.969 Contact Map
3fymA 1 0.0365 9.4 0.97 Contact Map
3j2wE 1 0.21 8.3 0.97 Contact Map
3hd7A 1 0.1735 8.3 0.97 Contact Map
3mp7B 1 0.2466 7.8 0.971 Contact Map
3w9iA 3 0.3516 7.6 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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