GREMLIN Database
DUF4190 - Domain of unknown function (DUF4190)
PFAM: PF13828 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 62 (61)
Sequences: 28522 (20741)
Seq/√Len: 2655.6
META: 0.91

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_H53_Y3.7511.00
31_L42_R2.1811.00
43_G47_A2.1131.00
22_L26_L1.9871.00
25_I29_I1.9751.00
31_L46_I1.8081.00
1_L33_Q1.7531.00
23_A52_G1.7001.00
35_R42_R1.6941.00
32_R36_R1.5381.00
42_R46_I1.4661.00
46_I50_V1.4541.00
6_L44_L1.4381.00
4_A8_L1.4381.00
5_S27_G1.3971.00
3_I44_L1.3621.00
33_Q39_L1.3331.00
47_A51_L1.3181.00
49_L53_Y1.2941.00
20_G55_G1.2611.00
4_A26_L1.2511.00
24_I28_H1.2411.00
28_H32_R1.2381.00
34_I39_L1.2251.00
31_L49_L1.2211.00
6_L10_I1.1931.00
30_A34_I1.1871.00
12_G55_G1.1751.00
31_L35_R1.1711.00
28_H49_L1.1411.00
9_G51_L1.1221.00
3_I7_V1.1201.00
34_I37_S1.0971.00
13_L55_G1.0961.00
5_S48_G1.0791.00
7_V11_L1.0131.00
53_Y57_V1.0071.00
50_V54_I1.0061.00
27_G49_L0.9861.00
27_G48_G0.9781.00
55_G59_L0.9531.00
8_L22_L0.9501.00
24_I49_L0.9341.00
12_G15_L0.9201.00
24_I53_Y0.9181.00
30_A45_A0.8521.00
18_L22_L0.8431.00
21_I25_I0.8421.00
2_A41_G0.8041.00
29_I33_Q0.8031.00
8_L26_L0.8031.00
18_L21_I0.8001.00
6_L47_A0.7931.00
20_G52_G0.7791.00
51_L55_G0.7671.00
34_I41_G0.7461.00
1_L26_L0.7431.00
46_I49_L0.7331.00
33_Q37_S0.7281.00
21_I56_L0.7241.00
20_G56_L0.7101.00
29_I32_R0.6991.00
54_I58_L0.6691.00
28_H31_L0.6671.00
17_L59_L0.6621.00
8_L19_L0.6601.00
24_I56_L0.6511.00
11_L15_L0.6501.00
19_L22_L0.6481.00
34_I40_G0.6311.00
30_A37_S0.6201.00
32_R35_R0.6121.00
1_L29_I0.6111.00
9_G48_G0.6101.00
27_G53_Y0.5991.00
4_A22_L0.5841.00
34_I42_R0.5781.00
9_G23_A0.5601.00
12_G20_G0.5521.00
22_L25_I0.5461.00
16_L19_L0.5451.00
11_L14_V0.5421.00
15_L59_L0.5321.00
44_L47_A0.5301.00
4_A7_V0.5261.00
13_L19_L0.5201.00
2_A9_G0.5191.00
26_L30_A0.5121.00
6_L51_L0.5081.00
24_I52_G0.5031.00
53_Y56_L0.5011.00
26_L29_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.5645 6.2 0.831 Contact Map
3w4tA 1 1 6 0.832 Contact Map
4us3A 1 0.3871 5.9 0.833 Contact Map
4humA 1 1 5.4 0.836 Contact Map
4lz6A 1 1 5.2 0.837 Contact Map
3mktA 1 1 5 0.838 Contact Map
4tq3A 1 1 3.7 0.848 Contact Map
2kluA 1 0.4032 3.3 0.852 Contact Map
4o9uB 2 0.8387 2.6 0.86 Contact Map
3ojoA 2 0.3065 2.2 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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