GREMLIN Database
DUF4189 - Domain of unknown function (DUF4189)
PFAM: PF13827 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 97 (96)
Sequences: 7246 (5350)
Seq/√Len: 546.0
META: 0.914

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R26_E3.4181.00
71_R75_E3.0441.00
26_E46_T2.7771.00
28_A32_E2.7051.00
21_S24_A2.2661.00
82_C90_C2.2431.00
19_Y28_A2.2211.00
30_L43_V2.1681.00
33_C41_C1.9651.00
47_F52_G1.9531.00
70_T73_E1.9521.00
5_A30_L1.7601.00
75_E95_S1.7101.00
2_G47_F1.7071.00
22_R46_T1.6841.00
50_G67_V1.6811.00
68_G77_A1.6791.00
55_A79_L1.6751.00
19_Y24_A1.6561.00
41_C51_C1.6391.00
55_A78_A1.6251.00
16_S19_Y1.5461.00
68_G73_E1.4721.00
7_S40_D1.4551.00
26_E43_V1.4401.00
81_E84_K1.4071.00
5_A43_V1.3981.00
77_A81_E1.3851.00
58_P89_D1.3771.00
53_A74_A1.3631.00
20_P24_A1.3371.00
41_C90_C1.2751.00
66_A77_A1.2681.00
1_W46_T1.2431.00
7_S10_G1.2351.00
73_E77_A1.2291.00
28_A31_A1.2241.00
14_G29_A1.1991.00
55_A92_V1.1751.00
76_N80_A1.1531.00
86_G89_D1.1251.00
47_F50_G1.1231.00
68_G74_A1.1181.00
71_R95_S1.1091.00
51_C97_C1.0961.00
27_A31_A1.0521.00
45_V52_G1.0421.00
23_A27_A1.0361.00
2_G52_G1.0181.00
7_S38_G1.0151.00
44_V63_Y1.0111.00
72_E76_N0.9951.00
5_A29_A0.9901.00
79_L92_V0.9791.00
53_A75_E0.9751.00
53_A92_V0.9581.00
15_Y94_A0.9581.00
75_E79_L0.9251.00
79_L83_R0.9181.00
53_A95_S0.9041.00
23_A26_E0.8951.00
24_A28_A0.8911.00
72_E75_E0.8771.00
8_P42_K0.8661.00
4_I52_G0.8651.00
57_G61_G0.8611.00
1_W48_R0.8451.00
70_T74_A0.8401.00
17_Y96_A0.8391.00
26_E30_L0.8371.00
13_Y94_A0.8221.00
3_A43_V0.8121.00
24_A27_A0.8081.00
74_A78_A0.8061.00
55_A75_E0.8021.00
16_S28_A0.7981.00
64_G78_A0.7921.00
6_Y44_V0.7791.00
80_A84_K0.7731.00
56_V93_R0.7661.00
69_A73_E0.7511.00
56_V91_K0.7351.00
57_G86_G0.7221.00
32_E36_K0.7161.00
9_S40_D0.7121.00
1_W22_R0.7101.00
41_C52_G0.7051.00
3_A25_A0.7031.00
80_A83_R0.7011.00
3_A46_T0.6951.00
15_Y32_E0.6931.00
6_Y10_G0.6721.00
47_F96_A0.6701.00
55_A64_G0.6671.00
37_G40_D0.6641.00
54_L63_Y0.6641.00
83_R86_G0.6501.00
27_A30_L0.6451.00
13_Y54_L0.6431.00
45_V65_W0.6401.00
35_A38_G0.6391.00
31_A35_A0.6381.00
19_Y25_A0.6381.00
57_G60_G0.6351.00
3_A26_E0.6281.00
44_V65_W0.6231.00
59_K62_G0.6141.00
75_E92_V0.6081.00
92_V95_S0.6081.00
73_E76_N0.6061.00
64_G81_E0.6061.00
57_G62_G0.6051.00
6_Y54_L0.5961.00
45_V67_V0.5851.00
5_A14_G0.5810.99
77_A80_A0.5750.99
12_A37_G0.5680.99
57_G87_G0.5620.99
66_A81_E0.5610.99
13_Y56_V0.5560.99
14_G32_E0.5510.99
6_Y56_V0.5490.99
16_S29_A0.5450.99
6_Y63_Y0.5440.99
19_Y32_E0.5420.99
6_Y11_G0.5310.99
1_W6_Y0.5290.99
49_N52_G0.5290.99
50_G69_A0.5280.99
58_P91_K0.5260.99
30_L42_K0.5260.99
83_R88_K0.5250.99
78_A92_V0.5250.99
5_A26_E0.5230.99
1_W26_E0.5230.99
17_Y95_S0.5220.99
18_N96_A0.5210.99
50_G95_S0.5190.99
65_W77_A0.5090.99
8_P12_A0.5030.99
51_C90_C0.5020.98
54_L94_A0.5020.98
58_P88_K0.5010.98
17_Y94_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w4lA 3 0.9588 8.7 0.866 Contact Map
2g6vA 2 0.9588 2.7 0.895 Contact Map
1z3aA 2 0.9897 1.9 0.904 Contact Map
3zpgA 2 0.9588 1.8 0.905 Contact Map
2b3zA 3 0.9485 1.6 0.906 Contact Map
4oh4F 1 0.1649 1.6 0.907 Contact Map
2hxvA 2 0.9485 1.6 0.907 Contact Map
1r02A 1 0.2165 1.4 0.911 Contact Map
2lzyA 1 0.1753 1.3 0.913 Contact Map
1fygA 1 0.1546 1 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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