GREMLIN Database
ACC_epsilon - Acyl-CoA carboxylase epsilon subunit
PFAM: PF13822 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 61 (60)
Sequences: 4847 (3341)
Seq/√Len: 431.3
META: 0.732

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_P49_R3.2921.00
5_V10_P3.0081.00
10_P15_L2.5351.00
42_A45_D2.0251.00
57_G61_W1.9231.00
25_R29_A1.8951.00
5_V15_L1.7991.00
51_R54_L1.7681.00
46_P50_L1.6861.00
42_A46_P1.6811.00
21_V25_R1.6611.00
41_S45_D1.4711.00
36_P39_R1.4411.00
19_V23_A1.4311.00
49_R52_R1.3991.00
56_P61_W1.3601.00
57_G60_A1.3521.00
3_L19_V1.3181.00
14_E17_A1.3071.00
19_V25_R1.2781.00
25_R28_A1.2611.00
3_L6_V1.2571.00
18_L23_A1.2471.00
18_L21_V1.2411.00
2_L5_V1.2221.00
29_A32_A1.2051.00
23_A26_A1.1851.00
56_P60_A1.1641.00
17_A21_V1.1441.00
8_G15_L1.1241.00
42_A47_A1.1091.00
2_L6_V1.0741.00
33_A36_P1.0361.00
9_D18_L1.0231.00
6_V10_P0.9891.00
7_R17_A0.9851.00
8_G18_L0.9821.00
44_A49_R0.9801.00
50_L54_L0.9781.00
34_P37_R0.9701.00
5_V18_L0.9601.00
48_R52_R0.9251.00
7_R18_L0.9141.00
43_W47_A0.8221.00
44_A56_P0.8221.00
56_P59_G0.8141.00
9_D15_L0.8081.00
22_L25_R0.7961.00
9_D12_P0.7801.00
31_A37_R0.7641.00
33_A37_R0.7231.00
15_L25_R0.7131.00
55_R58_P0.7091.00
41_S44_A0.6981.00
3_L21_V0.6821.00
24_A28_A0.6681.00
32_A38_R0.6631.00
33_A39_R0.6560.99
53_P60_A0.6540.99
44_A48_R0.6510.99
19_V22_L0.6460.99
7_R46_P0.6430.99
19_V26_A0.6390.99
30_A35_A0.6300.99
43_W51_R0.6280.99
31_A39_R0.6230.99
7_R10_P0.6150.99
4_R24_A0.6140.99
9_D20_A0.6130.99
29_A33_A0.5780.99
42_A48_R0.5660.98
27_A33_A0.5640.98
16_A22_L0.5630.98
16_A20_A0.5550.98
32_A37_R0.5520.98
3_L23_A0.5510.98
5_V8_G0.5490.98
10_P60_A0.5460.98
1_P4_R0.5460.98
23_A28_A0.5420.98
23_A27_A0.5420.98
48_R51_R0.5400.98
55_R59_G0.5390.98
42_A59_G0.5380.98
50_L53_P0.5230.97
54_L57_G0.5080.97
55_R60_A0.5080.97
47_A50_L0.5070.97
33_A38_R0.5050.97
48_R53_P0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kv9A 1 0.5082 28.2 0.795 Contact Map
1kb0A 1 0.459 19.6 0.81 Contact Map
3mk7C 2 0.3934 19.4 0.81 Contact Map
2l4dA 1 0.5574 18.9 0.812 Contact Map
1f1cA 2 0.4918 15.4 0.819 Contact Map
2yevB 1 0.5574 15.1 0.819 Contact Map
1dw0A 1 0.4098 15 0.82 Contact Map
1h32A 1 0.623 14.9 0.82 Contact Map
1cnoA 2 0.4426 14.7 0.821 Contact Map
1m70A 1 0.377 14 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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