GREMLIN Database
MBOAT_2 - Membrane bound O-acyl transferase family
PFAM: PF13813 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (65)
Sequences: 13642 (6166)
Seq/√Len: 764.7
META: 0.873

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_S10_K3.5531.00
30_L55_T3.1971.00
30_L59_S2.9661.00
47_R50_L2.7541.00
27_S31_R2.3211.00
12_T16_D1.9571.00
16_D21_R1.9221.00
43_G48_T1.8621.00
56_F59_S1.8121.00
45_K49_Y1.8081.00
16_D20_R1.6611.00
23_H26_L1.6041.00
24_I28_R1.5021.00
3_E6_N1.4641.00
46_A50_L1.4031.00
15_T56_F1.3631.00
24_I27_S1.3001.00
44_G48_T1.2821.00
46_A49_Y1.2691.00
4_N25_T1.2641.00
11_A16_D1.2181.00
11_A21_R1.1891.00
6_N24_I1.1651.00
39_G42_R1.1591.00
51_N55_T1.1591.00
45_K48_T1.1461.00
31_R36_I1.1291.00
50_L54_I1.1261.00
34_L37_P1.1041.00
6_N10_K1.0541.00
8_P21_R1.0521.00
64_G67_W1.0281.00
28_R32_D0.9951.00
43_G47_R0.9911.00
29_W33_Y0.9871.00
53_L57_L0.9761.00
39_G51_N0.9711.00
36_I41_N0.9671.00
55_T59_S0.9581.00
38_L54_I0.9501.00
36_I40_G0.9221.00
3_E7_S0.8991.00
43_G50_L0.8741.00
42_R50_L0.8361.00
30_L34_L0.8301.00
34_L38_L0.8181.00
34_L58_L0.8161.00
48_T59_S0.8151.00
36_I39_G0.8041.00
47_R51_N0.7921.00
52_L55_T0.7831.00
25_T28_R0.7791.00
33_Y37_P0.7711.00
26_L62_W0.7671.00
60_G64_G0.7561.00
49_Y52_L0.7501.00
32_D36_I0.7251.00
48_T52_L0.7131.00
15_T48_T0.7121.00
56_F63_H0.7041.00
3_E10_K0.6981.00
7_S59_S0.6921.00
48_T56_F0.6831.00
38_L42_R0.6791.00
20_R24_I0.6771.00
43_G51_N0.6771.00
26_L30_L0.6521.00
29_W32_D0.6491.00
25_T29_W0.6321.00
43_G46_A0.6301.00
39_G47_R0.6271.00
35_Y51_N0.6271.00
25_T62_W0.6261.00
4_N24_I0.6211.00
34_L54_I0.6201.00
13_S16_D0.6151.00
14_I65_A0.6061.00
44_G49_Y0.5991.00
35_Y55_T0.5901.00
27_S30_L0.5871.00
14_I23_H0.5821.00
34_L59_S0.5801.00
28_R31_R0.5801.00
31_R35_Y0.5771.00
26_L66_G0.5661.00
41_N44_G0.5661.00
38_L41_N0.5571.00
27_S55_T0.5461.00
9_Y17_F0.5441.00
29_W62_W0.5361.00
3_E59_S0.5361.00
3_E15_T0.5331.00
2_P25_T0.5291.00
52_L56_F0.5181.00
6_N21_R0.5061.00
23_H62_W0.5041.00
49_Y56_F0.5001.00
30_L58_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.9398 4.1 0.902 Contact Map
4hn9A 1 0.3253 2 0.917 Contact Map
1o7qA 1 0.3614 1.8 0.919 Contact Map
3pshA 1 0.3494 1.7 0.92 Contact Map
1qd5A 1 0.988 1.4 0.924 Contact Map
4mo9A 1 0.4217 1.3 0.925 Contact Map
3gzxA 3 0.4217 1.3 0.926 Contact Map
1qd6C 2 0.988 1.3 0.926 Contact Map
3iohA 2 0.241 1.2 0.926 Contact Map
1ijxA 2 0.3373 1 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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