GREMLIN Database
DUF4186 - Domain of unknown function (DUF4186)
PFAM: PF13811 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (107)
Sequences: 2476 (1703)
Seq/√Len: 164.6
META: 0.87

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_R96_E4.4061.00
43_A97_Q3.5481.00
40_D44_K3.0751.00
46_L80_L2.4541.00
99_Y103_V2.4031.00
24_A28_E2.3311.00
80_L100_V2.3311.00
38_A65_V2.2521.00
81_E88_K2.2271.00
84_H99_Y2.1871.00
19_G22_D2.1871.00
26_L31_L1.9851.00
39_R98_D1.9241.00
74_T104_I1.9031.00
35_R105_M1.8901.00
35_R102_A1.8081.00
23_R27_R1.7741.00
78_G88_K1.7641.00
26_L34_I1.6941.00
3_L103_V1.6631.00
20_G24_A1.6421.00
105_M108_I1.5871.00
42_I97_Q1.5801.00
36_E40_D1.5431.00
3_L6_R1.4651.00
22_D62_G1.4481.00
33_T36_E1.4221.00
25_Y64_P1.4061.00
19_G67_V1.3671.00
29_K33_T1.3401.00
11_K14_S1.3311.00
53_N56_K1.3041.00
87_P90_R1.2961.00
35_R101_V1.2831.00
11_K15_R1.2541.00
22_D67_V1.2511.00
24_A27_R1.2171.00
39_R97_Q1.2161.00
45_R69_Q1.2131.00
48_P51_P1.2031.00
94_E98_D1.1971.00
37_H41_F1.1771.00
43_A94_E1.1711.00
39_R43_A1.1641.00
26_L108_I1.1261.00
20_G23_R1.1261.00
75_C79_C1.1161.00
5_A9_R1.0981.00
49_A89_G1.0971.00
42_I100_V1.0891.00
46_L100_V1.0430.99
38_A101_V1.0370.99
51_P89_G1.0180.99
76_C79_C0.9980.99
16_F60_M0.9920.99
41_F45_R0.9880.99
47_A97_Q0.9860.99
36_E39_R0.9740.99
93_T96_E0.9620.99
33_T37_H0.9610.99
19_G62_G0.9500.99
51_P54_D0.9440.99
63_H66_F0.9310.99
80_L86_I0.9230.98
5_A8_A0.9130.98
74_T100_V0.8900.98
100_V104_I0.8850.98
44_K52_P0.8780.98
60_M67_V0.8600.98
21_K24_A0.8550.97
35_R39_R0.8240.97
6_R9_R0.8230.97
81_E87_P0.8220.97
26_L35_R0.8080.96
102_A105_M0.8080.96
15_R19_G0.7880.96
73_A83_W0.7850.96
7_L10_S0.7760.96
23_R26_L0.7740.95
101_V105_M0.7700.95
50_E89_G0.7650.95
2_E6_R0.7530.95
52_P56_K0.7490.95
94_E97_Q0.7400.94
10_S14_S0.7340.94
72_T104_I0.7330.94
32_D105_M0.7220.93
29_K37_H0.7210.93
54_D57_Q0.7170.93
81_E89_G0.7160.93
42_I101_V0.7050.93
19_G23_R0.7040.93
30_G33_T0.6930.92
43_A47_A0.6910.92
92_L100_V0.6910.92
97_Q101_V0.6870.92
61_R67_V0.6760.91
33_T83_W0.6760.91
86_I96_E0.6760.91
25_Y41_F0.6750.91
95_E98_D0.6700.91
8_A14_S0.6630.90
90_R93_T0.6620.90
12_F16_F0.6590.90
45_R66_F0.6520.89
4_F106_R0.6520.89
2_E8_A0.6470.89
2_E5_A0.6460.89
76_C83_W0.6430.89
4_F8_A0.6390.88
55_G58_T0.6270.88
29_K60_M0.6240.87
104_I107_W0.6240.87
13_R79_C0.6230.87
69_Q74_T0.6220.87
4_F14_S0.6170.87
27_R31_L0.6160.87
65_V104_I0.6120.86
22_D26_L0.6100.86
99_Y106_R0.6090.86
103_V106_R0.5930.84
75_C83_W0.5850.84
102_A106_R0.5810.83
99_Y108_I0.5810.83
47_A94_E0.5720.82
79_C83_W0.5720.82
2_E81_E0.5600.81
10_S83_W0.5580.81
37_H63_H0.5550.80
31_L35_R0.5540.80
3_L84_H0.5530.80
21_K28_E0.5500.80
23_R103_V0.5490.80
13_R75_C0.5470.79
10_S82_K0.5460.79
73_A79_C0.5440.79
4_F103_V0.5430.79
74_T80_L0.5380.78
26_L67_V0.5360.78
12_F15_R0.5350.78
49_A91_E0.5340.78
21_K67_V0.5330.78
61_R107_W0.5330.78
31_L105_M0.5330.78
14_S17_H0.5310.77
25_Y60_M0.5280.77
45_R61_R0.5260.77
51_P91_E0.5250.77
20_G27_R0.5240.77
25_Y29_K0.5230.76
39_R101_V0.5230.76
37_H40_D0.5170.76
3_L99_Y0.5160.75
42_I47_A0.5130.75
53_N60_M0.5130.75
90_R94_E0.5120.75
4_F10_S0.5100.75
66_F69_Q0.5040.74
18_L64_P0.5020.73
99_Y102_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m62A 1 0.9725 44.5 0.924 Contact Map
1vsy4 1 0.9266 40.6 0.925 Contact Map
2o35A 4 0.6697 21.4 0.935 Contact Map
3fybA 2 0.6881 19.1 0.937 Contact Map
4wz3B 1 0.9174 11.3 0.943 Contact Map
2c2lA 1 0.9174 10.1 0.944 Contact Map
1h8aC 1 0.2018 9.3 0.945 Contact Map
3beyA 6 0.7431 9.2 0.945 Contact Map
1w27A 4 0.7798 9.1 0.945 Contact Map
2yy9A 2 0.3945 9.1 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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