GREMLIN Database
DDE_Tnp_1_assoc - DDE_Tnp_1-associated
PFAM: PF13808 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (87)
Sequences: 38895 (21500)
Seq/√Len: 2305.1
META: 0.976

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_R15_G3.1051.00
49_E53_R2.3691.00
13_A16_K2.3451.00
27_A72_F2.3291.00
8_P79_A2.2311.00
69_R73_A2.2211.00
26_I45_G2.1241.00
5_A21_A1.8701.00
19_P22_D1.8601.00
35_A40_A1.8271.00
30_A41_I1.7821.00
23_I71_V1.7071.00
39_V65_H1.6701.00
37_S40_A1.6471.00
20_L71_V1.6231.00
19_P57_E1.5741.00
42_A46_R1.5721.00
81_E85_L1.5301.00
39_V69_R1.4961.00
12_R16_K1.4741.00
10_P74_R1.4691.00
65_H69_R1.4501.00
42_A65_H1.4361.00
38_W69_R1.4201.00
3_H86_A1.4151.00
79_A82_A1.4031.00
27_A41_I1.3781.00
6_E86_A1.3331.00
43_E47_A1.2971.00
67_T70_R1.2261.00
22_D57_E1.1871.00
17_R60_N1.1511.00
76_D79_A1.1481.00
38_W72_F1.1301.00
48_K52_L1.1251.00
84_F88_V1.1141.00
3_H83_C1.1011.00
6_E83_C1.1001.00
29_C52_L1.0661.00
82_A86_A1.0571.00
39_V43_E1.0521.00
58_L61_G1.0491.00
57_E61_G1.0411.00
30_A35_A1.0111.00
44_F48_K1.0001.00
7_L83_C0.9991.00
79_A83_C0.9751.00
31_V41_I0.9601.00
45_G68_F0.9591.00
7_L24_L0.9521.00
29_C44_F0.9511.00
26_I68_F0.9511.00
57_E60_N0.9461.00
3_H6_E0.9461.00
49_E52_L0.9351.00
42_A64_S0.9141.00
48_K51_W0.8931.00
64_S67_T0.8851.00
22_D56_L0.8821.00
27_A68_F0.8781.00
19_P59_P0.8771.00
25_V56_L0.8751.00
83_C86_A0.8621.00
30_A44_F0.8561.00
53_R62_I0.8511.00
77_P81_E0.8461.00
49_E62_I0.8411.00
66_D70_R0.8251.00
25_V29_C0.8241.00
78_E81_E0.8241.00
67_T71_V0.8231.00
46_R49_E0.7841.00
44_F52_L0.7811.00
23_I67_T0.7781.00
17_R21_A0.7761.00
23_I68_F0.7731.00
51_W55_F0.7721.00
42_A62_I0.7671.00
66_D69_R0.7501.00
70_R74_R0.7481.00
85_L88_V0.7421.00
50_E53_R0.7281.00
52_L56_L0.7131.00
26_I58_L0.7131.00
78_E82_A0.7121.00
2_E5_A0.7111.00
38_W65_H0.7101.00
16_K19_P0.7081.00
36_D40_A0.7061.00
10_P20_L0.7001.00
35_A41_I0.6931.00
21_A25_V0.6931.00
27_A31_V0.6891.00
22_D62_I0.6791.00
7_L20_L0.6761.00
75_L80_F0.6751.00
27_A38_W0.6641.00
22_D59_P0.6621.00
38_W73_A0.6621.00
28_L84_F0.6611.00
25_V55_F0.6571.00
71_V75_L0.6531.00
53_R57_E0.6481.00
33_C44_F0.6421.00
4_F28_L0.6391.00
10_P71_V0.6391.00
51_W54_R0.6341.00
70_R73_A0.6321.00
4_F83_C0.6281.00
45_G62_I0.5981.00
22_D26_I0.5911.00
23_I63_P0.5861.00
14_R17_R0.5821.00
24_L75_L0.5811.00
43_E46_R0.5781.00
81_E84_F0.5761.00
5_A8_P0.5751.00
39_V42_A0.5581.00
22_D58_L0.5561.00
7_L10_P0.5491.00
82_A85_L0.5471.00
9_D16_K0.5451.00
40_A43_E0.5421.00
81_E88_V0.5321.00
42_A45_G0.5181.00
50_E54_R0.5131.00
31_V35_A0.5121.00
35_A48_K0.5121.00
20_L24_L0.5051.00
22_D53_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d74B 1 0.9886 19.2 0.863 Contact Map
1iufA 1 0.8182 17.1 0.866 Contact Map
3j81l 1 0.0568 13.6 0.872 Contact Map
1neeA 1 0.9773 11.6 0.875 Contact Map
3cw2K 1 0.9773 11.3 0.876 Contact Map
2k5eA 1 0.6932 10.7 0.877 Contact Map
2fsqA 1 1 9.7 0.88 Contact Map
1bm9A 2 0.8182 9.4 0.88 Contact Map
2p0vA 2 0.375 8.2 0.884 Contact Map
2k53A 1 0.6705 7.8 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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