GREMLIN Database
DUF4184 - Domain of unknown function (DUF4184)
PFAM: PF13803 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 227 (224)
Sequences: 2449 (2093)
Seq/√Len: 139.8
META: 0.747

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_G109_L5.4481.00
119_W154_S4.8621.00
5_L8_P4.3581.00
23_S108_S4.2371.00
55_L113_A3.0901.00
6_S159_L3.0861.00
127_G130_V3.0101.00
58_F62_L2.8961.00
60_L110_L2.8561.00
152_H155_S2.8001.00
10_A115_T2.8001.00
25_S71_H2.7721.00
11_V31_S2.5881.00
217_G221_G2.3221.00
37_E41_R2.2361.00
33_A63_G2.2131.00
46_G49_T2.2111.00
71_H75_R2.1911.00
29_I63_G2.1111.00
123_T150_L2.1041.00
52_L56_F2.0301.00
59_D113_A1.9961.00
213_G217_G1.9881.00
55_L114_A1.9681.00
208_G212_V1.9101.00
140_V146_L1.9081.00
38_Y46_G1.9021.00
148_K152_H1.8631.00
86_L166_L1.8481.00
159_L163_A1.8431.00
212_V216_S1.8111.00
128_W132_H1.8061.00
29_I32_M1.7881.00
22_L108_S1.7631.00
121_S129_G1.7571.00
122_F129_G1.7541.00
105_V109_L1.7401.00
118_L122_F1.7401.00
8_P32_M1.7291.00
63_G113_A1.7261.00
177_S181_R1.7171.00
196_A199_R1.6991.00
28_V31_S1.6971.00
109_L113_A1.6321.00
26_A109_L1.5901.00
124_H151_Q1.5751.00
25_S67_L1.4761.00
23_S26_A1.4101.00
183_A186_L1.3881.00
15_R19_R1.3811.00
98_S101_R1.3741.00
84_A88_R1.3571.00
155_S159_L1.3471.00
118_L129_G1.3311.00
51_T54_G1.3311.00
148_K153_G1.3251.00
130_V147_Y1.3231.00
67_L105_V1.3161.00
216_S220_L1.3141.00
29_I67_L1.3041.00
104_L108_S1.3031.00
144_L148_K1.3011.00
29_I66_L1.2951.00
181_R184_Y1.2691.00
29_I33_A1.2691.00
41_R44_P1.2571.00
164_V168_R1.2561.00
33_A109_L1.2371.00
38_Y154_S1.2331.00
54_G57_T1.2301.00
37_E49_T1.2101.00
179_R183_A1.1931.00
55_L59_D1.1751.00
38_Y54_G1.1680.99
49_T58_F1.1680.99
180_R184_Y1.1530.99
130_V137_R1.1470.99
10_A119_W1.1430.99
57_T61_P1.1420.99
18_R22_L1.1090.99
68_L72_L1.1020.99
54_G59_D1.0750.99
94_W101_R1.0740.99
41_R45_L1.0700.99
71_H94_W1.0670.99
32_M36_F1.0650.99
6_S160_A1.0630.99
119_W158_G1.0590.99
41_R46_G1.0590.99
184_Y188_L1.0540.99
180_R183_A1.0480.99
200_A203_G1.0410.99
129_G133_L1.0390.99
56_F61_P1.0350.99
133_L136_L1.0260.99
199_R203_G1.0230.99
85_P89_R1.0210.99
84_A87_R1.0180.99
67_L109_L1.0140.99
64_L105_V1.0100.99
26_A67_L1.0090.99
3_F6_S1.0060.98
213_G216_S1.0020.98
114_A118_L1.0010.98
10_A154_S0.9880.98
2_P7_H0.9860.98
60_L113_A0.9850.98
146_L150_L0.9850.98
16_R19_R0.9810.98
188_L192_A0.9800.98
11_V27_L0.9790.98
138_E146_L0.9760.98
72_L95_R0.9690.98
106_L109_L0.9670.98
9_A12_L0.9660.98
208_G215_I0.9590.98
176_L181_R0.9520.98
201_A204_L0.9490.98
179_R184_Y0.9450.98
208_G211_V0.9410.98
48_F57_T0.9370.98
55_L110_L0.9340.98
111_I115_T0.9310.97
60_L106_L0.9280.97
25_S70_F0.9280.97
212_V215_I0.9270.97
132_H137_R0.9270.97
37_E43_R0.9220.97
25_S94_W0.9190.97
80_A90_L0.9150.97
44_P49_T0.9080.97
40_L44_P0.9080.97
24_L165_W0.9060.97
86_L89_R0.9040.97
33_A66_L0.8980.97
121_S127_G0.8970.97
221_G225_Y0.8940.97
178_P181_R0.8930.97
121_S132_H0.8740.96
53_L57_T0.8730.96
195_V199_R0.8640.96
121_S128_W0.8630.96
76_P161_V0.8610.96
70_F75_R0.8590.96
24_L63_G0.8590.96
59_D63_G0.8590.96
157_L161_V0.8500.96
53_L56_F0.8480.96
162_L166_L0.8440.96
214_A218_L0.8420.95
12_L24_L0.8410.95
26_A105_V0.8400.95
37_E42_L0.8380.95
134_P137_R0.8360.95
178_P182_L0.8330.95
9_A165_W0.8320.95
4_T7_H0.8300.95
96_R99_L0.8160.95
9_A162_L0.8110.94
19_R22_L0.8050.94
126_D131_R0.8040.94
176_L180_R0.7980.94
27_L111_I0.7960.94
51_T113_A0.7950.94
122_F151_Q0.7940.94
144_L156_V0.7910.94
1_M4_T0.7880.94
182_L192_A0.7850.93
182_L185_W0.7840.93
24_L28_V0.7800.93
196_A200_A0.7770.93
209_T212_V0.7760.93
197_A201_A0.7730.93
33_A113_A0.7710.93
182_L186_L0.7700.93
129_G136_L0.7650.93
49_T54_G0.7640.92
124_H150_L0.7630.92
135_A146_L0.7630.92
17_L20_R0.7620.92
186_L190_L0.7590.92
187_A191_L0.7590.92
104_L107_L0.7540.92
56_F59_D0.7540.92
113_A117_L0.7520.92
94_W97_R0.7500.92
127_G131_R0.7490.92
195_V198_L0.7460.92
102_W106_L0.7420.91
189_A193_L0.7410.91
8_P11_V0.7390.91
48_F54_G0.7380.91
200_A204_L0.7370.91
119_W152_H0.7300.91
145_P148_K0.7250.90
94_W98_S0.7240.90
48_F51_T0.7230.90
168_R172_R0.7210.90
189_A192_A0.7170.90
61_P70_F0.7130.90
129_G132_H0.7050.89
174_P180_R0.7040.89
8_P31_S0.7020.89
195_V200_A0.6950.88
208_G219_L0.6940.88
54_G61_P0.6910.88
71_H108_S0.6880.88
209_T215_I0.6870.88
75_R92_A0.6840.88
55_L117_L0.6830.88
174_P193_L0.6790.87
133_L137_R0.6790.87
22_L104_L0.6790.87
30_G34_P0.6770.87
187_A193_L0.6760.87
156_V159_L0.6760.87
6_S15_R0.6740.87
159_L162_L0.6680.86
3_F159_L0.6670.86
144_L149_L0.6660.86
210_L220_L0.6650.86
123_T151_Q0.6650.86
210_L219_L0.6650.86
164_V186_L0.6640.86
135_A138_E0.6630.86
178_P183_A0.6590.86
24_L108_S0.6580.86
164_V167_L0.6570.86
181_R188_L0.6530.85
4_T151_Q0.6530.85
68_L98_S0.6520.85
67_L71_H0.6490.85
9_A38_Y0.6480.85
58_F61_P0.6470.85
208_G216_S0.6440.84
1_M7_H0.6420.84
79_I91_A0.6410.84
12_L165_W0.6380.84
46_G102_W0.6360.84
28_V32_M0.6350.84
56_F110_L0.6350.84
23_S42_L0.6340.83
96_R101_R0.6310.83
33_A38_Y0.6270.83
175_R181_R0.6180.82
87_R181_R0.6170.82
79_I87_R0.6140.81
36_F215_I0.6140.81
18_R24_L0.6140.81
18_R21_R0.6110.81
196_A201_A0.6100.81
212_V220_L0.6050.81
14_L20_R0.6050.81
165_W169_W0.6040.80
180_R188_L0.5980.80
56_F114_A0.5970.80
29_I105_V0.5880.79
149_L152_H0.5870.79
185_W188_L0.5860.78
211_V215_I0.5860.78
75_R79_I0.5850.78
199_R202_F0.5850.78
67_L94_W0.5840.78
222_L225_Y0.5840.78
22_L115_T0.5800.78
210_L217_G0.5800.78
197_A200_A0.5790.78
160_A167_L0.5780.77
15_R22_L0.5760.77
203_G206_A0.5750.77
15_R18_R0.5730.77
74_L223_L0.5690.76
3_F39_F0.5680.76
157_L204_L0.5660.76
63_G105_V0.5650.76
151_Q154_S0.5640.76
209_T222_L0.5620.75
132_H135_A0.5600.75
40_L62_L0.5550.75
97_R101_R0.5550.75
92_A95_R0.5520.74
32_M151_Q0.5520.74
9_A161_V0.5510.74
40_L43_R0.5490.74
206_A219_L0.5480.74
118_L121_S0.5470.74
37_E48_F0.5460.73
210_L218_L0.5460.73
206_A209_T0.5440.73
183_A188_L0.5430.73
41_R49_T0.5420.73
181_R185_W0.5410.73
190_L193_L0.5410.73
38_Y129_G0.5400.73
140_V149_L0.5400.73
195_V221_G0.5400.73
176_L184_Y0.5380.72
209_T213_G0.5360.72
49_T80_A0.5360.72
195_V217_G0.5350.72
39_F58_F0.5350.72
20_R104_L0.5350.72
134_P138_E0.5340.72
46_G51_T0.5330.72
208_G213_G0.5330.72
17_L22_L0.5320.71
201_A206_A0.5320.71
65_L73_L0.5300.71
100_R104_L0.5300.71
71_H78_L0.5290.71
39_F215_I0.5280.71
148_K155_S0.5270.71
78_L96_R0.5270.71
119_W162_L0.5260.71
69_L73_L0.5240.70
43_R46_G0.5200.70
6_S155_S0.5200.70
188_L225_Y0.5190.70
175_R178_P0.5180.69
177_S183_A0.5160.69
127_G146_L0.5160.69
2_P13_P0.5150.69
130_V136_L0.5150.69
115_T151_Q0.5140.69
64_L68_L0.5130.69
9_A155_S0.5120.69
64_L180_R0.5110.68
36_F66_L0.5110.68
67_L108_S0.5110.68
209_T216_S0.5100.68
8_P24_L0.5070.68
82_L85_P0.5040.67
53_L62_L0.5040.67
52_L114_A0.5010.67
220_L223_L0.5010.67
198_L202_F0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.5859 12.9 0.954 Contact Map
1oedB 1 0.348 8.8 0.957 Contact Map
1oedC 1 0.348 8.6 0.958 Contact Map
1oedA 1 0.348 7.6 0.959 Contact Map
1oedE 1 0.3524 6.8 0.959 Contact Map
3pjsK 4 0.3789 5.6 0.961 Contact Map
4pypA 1 0.5066 5.2 0.962 Contact Map
3effK 4 0.3789 3.4 0.965 Contact Map
4av3A 2 0.3524 3 0.966 Contact Map
2m6bA 1 0.3744 2.4 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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