GREMLIN Database
DUF4183 - Domain of unknown function (DUF4183)
PFAM: PF13799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (82)
Sequences: 809 (585)
Seq/√Len: 64.5
META: 0.633

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_L78_T4.5411.00
61_V82_L3.8251.00
29_D33_A2.7951.00
47_L61_V2.6331.00
49_I80_I2.5051.00
46_N83_E2.4981.00
60_T69_N2.3091.00
13_E21_T2.0861.00
46_N53_L2.0461.00
48_Y83_E1.9741.00
6_Y73_A1.8621.00
58_N70_T1.6760.99
10_N80_I1.5550.99
29_D35_A1.5460.99
5_R46_N1.5270.99
45_Y83_E1.5030.99
24_A63_T1.4880.98
52_V79_P1.4470.98
62_T67_T1.4280.98
34_A37_A1.4180.98
5_R56_G1.3830.97
22_I38_F1.3200.97
7_F67_T1.3120.97
66_L69_N1.2830.96
58_N68_L1.1980.94
28_T34_A1.1930.94
62_T65_S1.1780.94
33_A37_A1.1740.94
70_T73_A1.1300.92
32_G43_S1.1230.92
2_D5_R1.1000.91
11_T48_Y1.0960.91
31_A36_T1.0890.91
60_T65_S1.0750.90
11_T24_A1.0560.89
7_F27_F1.0550.89
53_L82_L1.0160.87
65_S68_L0.9910.86
55_P58_N0.9500.84
49_I68_L0.9450.83
25_P38_F0.9430.83
24_A27_F0.9390.83
55_P66_L0.9330.83
27_F63_T0.9270.82
28_T35_A0.9260.82
28_T64_G0.9230.82
6_Y51_G0.9160.81
19_T48_Y0.9150.81
20_L56_G0.9060.81
2_D40_A0.8960.80
5_R30_D0.8840.79
31_A34_A0.8840.79
6_Y45_Y0.8390.75
3_G73_A0.8310.75
67_T82_L0.8180.73
52_V75_L0.8080.73
29_D32_G0.8040.72
62_T83_E0.8000.72
49_I71_G0.7970.71
43_S55_P0.7880.71
16_E48_Y0.7810.70
33_A36_T0.7790.70
6_Y56_G0.7770.70
3_G81_I0.7750.69
27_F56_G0.7600.68
30_D48_Y0.7550.67
11_T57_G0.7550.67
15_T51_G0.7490.67
38_F41_L0.7450.66
61_V83_E0.7310.65
11_T20_L0.7260.64
41_L61_V0.7180.63
25_P36_T0.7150.63
75_L80_I0.7150.63
20_L27_F0.7120.63
12_D35_A0.7110.63
22_I31_A0.7070.62
9_T28_T0.7060.62
4_T56_G0.7060.62
47_L66_L0.7030.62
24_A69_N0.7020.62
62_T71_G0.7020.62
24_A35_A0.6960.61
4_T76_A0.6930.61
6_Y26_S0.6850.60
27_F83_E0.6840.60
21_T45_Y0.6800.59
76_A81_I0.6750.59
78_T83_E0.6670.58
21_T65_S0.6480.56
24_A44_Y0.6370.54
71_G83_E0.6340.54
38_F79_P0.6310.54
37_A64_G0.6290.53
8_Y22_I0.6200.52
19_T69_N0.6150.52
20_L77_G0.5940.49
7_F65_S0.5930.49
33_A41_L0.5910.49
46_N81_I0.5880.49
5_R48_Y0.5820.48
25_P35_A0.5810.48
53_L81_I0.5780.47
2_D51_G0.5770.47
19_T62_T0.5710.47
69_N74_P0.5700.47
5_R83_E0.5660.46
27_F60_T0.5640.46
10_N14_L0.5610.45
18_G28_T0.5530.45
15_T67_T0.5490.44
20_L80_I0.5410.43
13_E20_L0.5400.43
51_G61_V0.5360.43
55_P64_G0.5290.42
7_F75_L0.5290.42
23_L34_A0.5230.41
14_L26_S0.5200.41
6_Y16_E0.5100.40
18_G36_T0.5100.40
37_A41_L0.5070.39
43_S49_I0.5060.39
21_T58_N0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ffzA 1 0.7619 21.3 0.887 Contact Map
2uvfA 2 0.8095 16.7 0.892 Contact Map
2vxrA 1 0.5833 14.8 0.894 Contact Map
3rsjA 1 0.5833 13.7 0.896 Contact Map
3waiA 1 0.9286 8.5 0.905 Contact Map
2nyyA 1 0.7619 7.6 0.908 Contact Map
3skvA 2 0.8452 7.4 0.908 Contact Map
3pmqA 1 0.9762 7.4 0.908 Contact Map
4qtfA 2 0.7857 7 0.909 Contact Map
4v2xA 2 0.9881 6.4 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0045 seconds.