GREMLIN Database
PCYCGC - Protein of unknown function with PCYCGC motif
PFAM: PF13798 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 155 (151)
Sequences: 501 (397)
Seq/√Len: 32.3
META: 0.639

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_E141_K4.9211.00
92_F118_A3.7461.00
92_F108_G3.6011.00
59_A115_L3.0391.00
62_A122_I2.9411.00
129_K133_E2.8521.00
125_K131_L2.5671.00
106_D110_R2.1610.99
124_M127_E2.1600.99
66_H69_L2.0460.98
63_A70_L2.0360.98
73_I121_S1.9380.97
69_L131_L1.9200.97
88_N117_I1.8970.97
36_Q94_A1.8770.97
62_A119_L1.8000.96
25_H28_H1.7940.96
3_L6_A1.7150.94
67_P96_V1.6960.94
69_L125_K1.6700.93
32_N35_L1.6540.93
124_M137_A1.6470.93
123_K127_E1.6370.93
9_L13_G1.5810.91
45_L135_R1.5730.91
88_N109_T1.5710.91
59_A119_L1.5630.91
56_V115_L1.5250.90
115_L119_L1.4700.88
90_D110_R1.4390.87
75_C85_H1.4250.86
38_T97_K1.3710.84
74_P135_R1.3680.84
73_I131_L1.3460.83
23_H26_A1.3450.83
63_A89_L1.3350.82
8_L11_A1.3170.82
85_H91_C1.3100.81
108_G115_L1.3060.81
35_L110_R1.2870.80
106_D109_T1.2600.79
119_L122_I1.2430.78
140_E143_K1.2390.77
96_V102_V1.2340.77
59_A122_I1.2290.77
86_K90_D1.2280.77
8_L22_E1.2270.77
37_E49_L1.2230.76
10_A21_A1.2210.76
26_A29_A1.2010.75
77_C114_C1.1730.73
79_C114_C1.1730.73
87_S94_A1.1730.73
49_L104_W1.1720.73
70_L121_S1.1640.73
89_L96_V1.1600.73
122_I126_K1.1580.72
32_N83_A1.1510.72
110_R113_V1.1430.71
39_T48_F1.1420.71
64_A104_W1.1370.71
50_D57_R1.1330.71
75_C79_C1.1310.71
75_C114_C1.1310.71
45_L49_L1.1190.70
135_R138_I1.1110.69
23_H31_A1.1000.68
77_C91_C1.0740.67
91_C114_C1.0740.67
79_C91_C1.0740.67
39_T49_L1.0700.66
61_Q65_K1.0590.65
90_D105_D1.0570.65
12_C139_D1.0540.65
80_G84_G1.0350.64
75_C91_C1.0280.63
120_E137_A1.0190.62
76_Y129_K1.0170.62
71_E89_L1.0170.62
68_D138_I1.0170.62
150_T153_P1.0080.62
58_L61_Q1.0050.61
97_K103_V0.9920.60
42_A102_V0.9870.60
107_H111_C0.9660.58
7_L16_E0.9640.58
5_L16_E0.9520.57
15_K19_S0.9490.57
56_V108_G0.9460.57
9_L12_C0.9400.56
112_G116_E0.9330.56
71_E102_V0.9290.55
85_H114_C0.9240.55
79_C85_H0.9240.55
77_C85_H0.9240.55
48_F106_D0.9180.54
94_A101_S0.9120.54
24_E133_E0.9070.53
27_Q30_A0.9010.53
95_E100_G0.8930.52
128_G139_D0.8910.52
69_L115_L0.8720.51
18_S23_H0.8650.50
70_L105_D0.8650.50
122_I131_L0.8490.49
39_T46_P0.8480.49
72_W89_L0.8470.49
67_P89_L0.8420.48
83_A106_D0.8400.48
106_D113_V0.8400.48
15_K140_E0.8350.48
79_C111_C0.8330.47
77_C111_C0.8330.47
111_C114_C0.8330.47
13_G40_A0.8310.47
11_A116_E0.8230.47
34_D39_T0.8230.47
8_L16_E0.8230.47
87_S90_D0.8210.46
71_E87_S0.8180.46
15_K23_H0.8160.46
6_A17_A0.8100.45
135_R152_T0.8100.45
19_S31_A0.7980.44
74_P90_D0.7800.43
11_A153_P0.7800.43
97_K101_S0.7790.43
46_P107_H0.7780.43
75_C111_C0.7780.43
70_L88_N0.7740.43
146_Y149_P0.7680.42
23_H28_H0.7670.42
5_L98_E0.7630.42
105_D110_R0.7570.41
20_A24_E0.7560.41
31_A47_S0.7540.41
134_I139_D0.7540.41
81_E108_G0.7490.41
4_L7_L0.7460.40
51_D130_S0.7450.40
32_N36_Q0.7410.40
76_Y131_L0.7280.39
8_L18_S0.7270.39
91_C111_C0.7250.39
10_A17_A0.7220.38
89_L112_G0.7200.38
10_A23_H0.7080.37
4_L19_S0.7060.37
80_G139_D0.7020.37
3_L8_L0.7000.37
45_L142_Y0.6960.36
105_D117_I0.6900.36
9_L16_E0.6870.36
72_W95_E0.6870.36
72_W124_M0.6840.35
37_E93_I0.6750.35
81_E92_F0.6740.35
48_F104_W0.6700.34
63_A103_V0.6640.34
33_G147_A0.6620.34
32_N110_R0.6570.33
17_A24_E0.6560.33
41_S110_R0.6540.33
37_E48_F0.6520.33
65_K81_E0.6490.33
31_A34_D0.6490.33
62_A65_K0.6440.33
39_T104_W0.6420.32
18_S136_Q0.6380.32
56_V125_K0.6370.32
6_A15_K0.6350.32
59_A108_G0.6330.32
90_D113_V0.6310.32
52_K109_T0.6300.32
18_S121_S0.6290.31
130_S151_P0.6280.31
7_L24_E0.6280.31
83_A108_G0.6230.31
86_K118_A0.6210.31
54_E57_R0.6200.31
57_R67_P0.6170.31
97_K100_G0.6160.31
22_E28_H0.6140.30
58_L62_A0.6120.30
43_D65_K0.6070.30
32_N108_G0.5990.29
55_E140_E0.5960.29
108_G116_E0.5950.29
48_F109_T0.5870.29
29_A98_E0.5860.28
3_L16_E0.5780.28
22_E26_A0.5770.28
66_H151_P0.5650.27
52_K56_V0.5650.27
92_F142_Y0.5600.27
96_V100_G0.5580.27
33_G82_S0.5560.27
66_H132_K0.5540.26
85_H111_C0.5540.26
36_Q105_D0.5490.26
89_L151_P0.5470.26
19_S24_E0.5470.26
11_A17_A0.5470.26
54_E58_L0.5450.26
69_L73_I0.5410.26
145_G149_P0.5400.25
10_A26_A0.5340.25
43_D50_D0.5320.25
33_G38_T0.5320.25
29_A148_K0.5310.25
24_E129_K0.5300.25
78_G128_G0.5280.25
32_N50_D0.5240.25
57_R63_A0.5220.24
63_A122_I0.5210.24
38_T101_S0.5200.24
25_H29_A0.5200.24
62_A66_H0.5180.24
72_W131_L0.5170.24
66_H119_L0.5170.24
99_D106_D0.5140.24
133_E137_A0.5100.24
119_L123_K0.5020.23
57_R97_K0.5020.23
113_V146_Y0.5020.23
70_L118_A0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kw0A 1 0.5226 73.4 0.923 Contact Map
2hl7A 1 0.5161 58.9 0.93 Contact Map
3bqpA 1 0.2839 55.3 0.931 Contact Map
1l9lA 1 0.271 49.5 0.933 Contact Map
1nklA 1 0.271 43.4 0.936 Contact Map
3zbiC 1 0.1806 30.1 0.941 Contact Map
2gtgA 1 0.2774 26.6 0.943 Contact Map
1of9A 1 0.2774 24.4 0.944 Contact Map
3s64A 2 0.3032 19 0.946 Contact Map
1n69A 2 0.2903 18.2 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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