GREMLIN Database
Sensor - Putative sensor
PFAM: PF13796 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 162 (162)
Sequences: 9523 (7306)
Seq/√Len: 574.0
META: 0.757

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_T124_W2.9371.00
15_V42_A2.7691.00
48_A64_R2.6891.00
79_R83_R2.6471.00
66_P90_D2.6161.00
76_R79_R2.5281.00
14_V18_T2.3821.00
10_I14_V2.3111.00
19_G39_T2.2851.00
17_V21_S2.2171.00
55_R61_R2.1641.00
102_I106_V2.1391.00
54_A158_A2.1211.00
50_E53_R2.0491.00
7_P10_I2.0051.00
99_P102_I1.9801.00
23_G35_L1.8991.00
126_L129_A1.8291.00
73_G76_R1.7961.00
13_F17_V1.7061.00
85_P89_R1.6951.00
8_L12_Y1.6041.00
15_V19_G1.5991.00
115_G140_L1.5681.00
23_G36_L1.5501.00
30_L34_P1.5341.00
121_A132_A1.5181.00
115_G139_L1.5111.00
120_T123_L1.4861.00
86_A90_D1.4601.00
47_A90_D1.4511.00
54_A58_L1.4491.00
45_G48_A1.4471.00
130_L134_A1.4041.00
44_R84_D1.4021.00
86_A89_R1.3861.00
44_R87_T1.3831.00
18_T22_L1.3611.00
96_L157_L1.3591.00
141_L144_P1.3361.00
43_A94_L1.3351.00
11_A14_V1.3281.00
157_L160_A1.3261.00
127_P130_L1.3151.00
55_R60_V1.3141.00
106_V110_T1.2961.00
24_L28_V1.2791.00
111_L143_A1.2611.00
16_L94_L1.2591.00
34_P37_A1.2551.00
152_R156_A1.2491.00
6_L10_I1.2361.00
22_L26_L1.2341.00
67_P70_R1.2281.00
62_I158_A1.2221.00
60_V155_A1.2171.00
153_L156_A1.2131.00
43_A91_L1.2081.00
129_A133_A1.2011.00
72_G76_R1.2001.00
25_G28_V1.1991.00
21_S25_G1.1981.00
126_L130_L1.1971.00
12_Y46_L1.1911.00
60_V159_R1.1751.00
115_G143_A1.1701.00
44_R90_D1.1681.00
149_G153_L1.1631.00
7_P11_A1.1631.00
99_P103_V1.1631.00
108_A112_W1.1621.00
40_L87_T1.1481.00
156_A160_A1.1381.00
11_A15_V1.1261.00
23_G39_T1.1191.00
104_A150_L1.1101.00
22_L25_G1.1051.00
112_W147_A1.1011.00
84_D87_T1.0891.00
114_V117_A1.0851.00
53_R97_K1.0771.00
46_L94_L1.0761.00
145_W148_R1.0721.00
53_R56_A1.0651.00
95_L99_P1.0611.00
72_G80_A1.0591.00
98_L102_I1.0561.00
68_R71_P1.0561.00
67_P71_P1.0541.00
148_R152_R1.0521.00
144_P148_R1.0501.00
51_R62_I1.0481.00
38_L41_L1.0291.00
23_G27_L1.0091.00
137_L141_L1.0071.00
125_T128_E0.9981.00
41_L45_G0.9971.00
155_A159_R0.9871.00
109_V113_A0.9811.00
49_L52_R0.9671.00
100_L157_L0.9671.00
110_T114_V0.9661.00
10_I18_T0.9651.00
26_L29_L0.9651.00
105_F109_V0.9511.00
27_L33_L0.9451.00
5_G53_R0.9341.00
122_P133_A0.9331.00
76_R80_A0.9231.00
100_L104_A0.9161.00
1_Y93_Y0.9121.00
48_A52_R0.9031.00
14_V22_L0.9021.00
31_V34_P0.8941.00
40_L43_A0.8851.00
1_Y5_G0.8761.00
102_I105_F0.8731.00
18_T21_S0.8731.00
25_G29_L0.8701.00
151_A155_A0.8611.00
52_R56_A0.8591.00
41_L81_R0.8571.00
127_P131_L0.8561.00
96_L99_P0.8491.00
141_L145_W0.8481.00
119_L122_P0.8431.00
119_L137_L0.8411.00
140_L144_P0.8411.00
97_K100_L0.8241.00
74_L77_R0.8211.00
75_W79_R0.8211.00
97_K154_H0.8181.00
111_L142_A0.8171.00
45_G49_L0.8141.00
40_L91_L0.8121.00
52_R55_R0.8101.00
43_A87_T0.8101.00
50_E97_K0.8041.00
51_R89_R0.8001.00
129_A132_A0.7991.00
103_V107_L0.7971.00
42_A45_G0.7971.00
148_R151_A0.7901.00
93_Y97_K0.7841.00
108_A147_A0.7821.00
66_P86_A0.7821.00
122_P136_G0.7811.00
149_G152_R0.7811.00
134_A138_L0.7691.00
32_G35_L0.7681.00
36_L40_L0.7621.00
156_A159_R0.7581.00
9_G97_K0.7511.00
40_L82_L0.7441.00
87_T90_D0.7421.00
4_L7_P0.7341.00
69_P80_A0.7341.00
118_L121_A0.7281.00
103_V106_V0.7271.00
136_G140_L0.7271.00
16_L91_L0.7221.00
38_L42_A0.7201.00
139_L142_A0.7161.00
130_L133_A0.7091.00
66_P84_D0.7071.00
102_I110_T0.7061.00
117_A121_A0.7041.00
157_L161_L0.6971.00
51_R90_D0.6951.00
65_P86_A0.6921.00
93_Y158_A0.6901.00
152_R155_A0.6881.00
47_A65_P0.6861.00
133_A137_L0.6821.00
89_R92_A0.6781.00
142_A146_L0.6771.00
118_L122_P0.6711.00
98_L101_G0.6691.00
6_L14_V0.6681.00
6_L105_F0.6641.00
50_E94_L0.6631.00
116_L120_T0.6541.00
50_E158_A0.6531.00
114_V118_L0.6481.00
12_Y94_L0.6431.00
16_L43_A0.6401.00
112_W143_A0.6391.00
151_A154_H0.6381.00
53_R154_H0.6341.00
128_E132_A0.6271.00
26_L30_L0.6191.00
115_G118_L0.6161.00
44_R81_R0.6121.00
144_P154_H0.6121.00
42_A46_L0.6101.00
87_T91_L0.6051.00
1_Y53_R0.6051.00
62_I65_P0.5991.00
47_A50_E0.5981.00
78_L81_R0.5941.00
117_A124_W0.5911.00
73_G77_R0.5881.00
54_A57_L0.5871.00
6_L98_L0.5791.00
143_A147_A0.5771.00
12_Y16_L0.5711.00
5_G154_H0.5711.00
142_A145_W0.5690.99
40_L90_D0.5690.99
118_L132_A0.5660.99
55_R62_I0.5620.99
125_T129_A0.5580.99
1_Y54_A0.5570.99
43_A90_D0.5440.99
22_L29_L0.5440.99
108_A111_L0.5430.99
114_V139_L0.5400.99
108_A150_L0.5390.99
115_G119_L0.5390.99
49_L53_R0.5360.99
131_L135_L0.5310.99
154_H158_A0.5300.99
135_L139_L0.5300.99
12_Y19_G0.5290.99
37_A41_L0.5280.99
106_V109_V0.5280.99
100_L154_H0.5240.99
75_W78_L0.5220.99
74_L78_L0.5210.99
9_G101_G0.5200.99
80_A83_R0.5200.99
150_L153_L0.5180.99
50_E154_H0.5170.99
13_F16_L0.5160.99
21_S27_L0.5130.99
115_G141_L0.5130.99
145_W149_G0.5110.99
22_L35_L0.5080.99
153_L157_L0.5070.99
126_L133_A0.5060.99
10_I98_L0.5040.99
13_F98_L0.5030.99
44_R77_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hkrA 3 0.679 1.9 0.933 Contact Map
4wisA 2 0.8951 1.2 0.941 Contact Map
3giaA 1 0.3642 1.1 0.942 Contact Map
4jweC 1 0.0617 1.1 0.943 Contact Map
2m20A 2 0.3642 0.8 0.946 Contact Map
1a87A 1 0.3704 0.7 0.949 Contact Map
4p02B 1 0.3086 0.7 0.95 Contact Map
2kncB 1 0.4568 0.6 0.951 Contact Map
4c7rA 3 0.4691 0.6 0.951 Contact Map
1f2vA 2 0.4012 0.6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0061 seconds.