GREMLIN Database
HupE_UreJ_2 - HupE / UreJ protein
PFAM: PF13795 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 154 (151)
Sequences: 21499 (11406)
Seq/√Len: 928.2
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_R36_K4.3071.00
2_L135_L3.8051.00
63_L66_A3.2031.00
30_R33_R2.9521.00
3_R7_E2.7591.00
4_L7_E2.5671.00
33_R36_K2.3221.00
38_V141_V2.3001.00
7_E11_T2.2821.00
68_I107_G2.2471.00
16_L140_V2.1591.00
55_G58_S2.0021.00
40_A94_W1.9391.00
21_G75_V1.8981.00
51_L56_L1.8781.00
67_L103_I1.8631.00
52_A106_F1.8351.00
57_V106_F1.8181.00
124_L128_S1.7751.00
20_L144_V1.7001.00
63_L67_L1.6531.00
77_L81_R1.6481.00
44_A98_F1.6351.00
40_A98_F1.6321.00
78_E93_R1.5881.00
74_Y78_E1.5591.00
55_G113_R1.5491.00
62_R66_A1.5451.00
61_S110_G1.5371.00
35_L138_L1.5101.00
92_R95_L1.4471.00
21_G76_A1.4411.00
2_L128_S1.3741.00
6_V135_L1.3641.00
122_L125_A1.3621.00
95_L99_A1.3491.00
50_A54_L1.3481.00
37_T97_A1.3211.00
143_A146_P1.3101.00
11_T111_A1.3061.00
131_V135_L1.2911.00
50_A53_A1.2871.00
99_A103_I1.2751.00
6_V139_A1.2571.00
7_E10_L1.2441.00
81_R85_R1.2401.00
6_V10_L1.2371.00
144_V148_L1.2101.00
40_A97_A1.2081.00
60_P63_L1.1901.00
51_L57_V1.1731.00
48_T102_L1.1701.00
53_A112_L1.1511.00
46_S130_N1.1361.00
146_P150_L1.1341.00
54_L122_L1.1281.00
31_L35_L1.1221.00
66_A70_L1.1221.00
59_L63_L1.0971.00
85_R88_L1.0941.00
2_L6_V1.0941.00
45_H134_E1.0921.00
22_L97_A1.0821.00
29_R33_R1.0821.00
36_K94_W1.0801.00
34_L38_V1.0621.00
8_H15_H1.0601.00
58_S113_R1.0581.00
20_L140_V1.0521.00
9_I133_V1.0501.00
61_S66_A1.0481.00
130_N137_Q1.0481.00
139_A142_A1.0481.00
147_L150_L1.0461.00
123_L127_L1.0461.00
9_I136_G1.0441.00
4_L115_L1.0381.00
120_G124_L1.0341.00
139_A143_A1.0331.00
16_L20_L1.0311.00
51_L55_G1.0311.00
140_V144_V1.0281.00
86_P90_R1.0211.00
59_L106_F1.0201.00
116_G119_G1.0201.00
27_L30_R1.0131.00
150_L153_R1.0011.00
146_P149_A1.0001.00
145_L149_A0.9981.00
82_F85_R0.9931.00
127_L131_V0.9901.00
138_L142_A0.9871.00
33_R93_R0.9691.00
23_L141_V0.9631.00
10_L139_A0.9501.00
47_I51_L0.9421.00
148_L152_R0.9351.00
128_S131_V0.9321.00
15_H104_H0.9321.00
87_G90_R0.9231.00
149_A152_R0.9131.00
142_A146_P0.9001.00
19_L38_V0.8981.00
111_A115_L0.8961.00
149_A153_R0.8831.00
81_R84_G0.8761.00
107_G111_A0.8691.00
101_G105_G0.8661.00
71_S75_V0.8641.00
23_L144_V0.8641.00
73_V77_L0.8631.00
86_P91_R0.8461.00
119_G122_L0.8461.00
6_V11_T0.8371.00
121_A125_A0.8291.00
13_Y17_L0.8261.00
133_V136_G0.8251.00
79_N93_R0.8241.00
121_A124_L0.8231.00
1_Y4_L0.8151.00
86_P89_T0.8131.00
53_A123_L0.8071.00
145_L148_L0.8041.00
118_P125_A0.8001.00
130_N134_E0.7971.00
46_S49_L0.7961.00
89_T92_R0.7941.00
124_L127_L0.7941.00
78_E92_R0.7911.00
70_L73_V0.7861.00
118_P121_A0.7731.00
58_S62_R0.7671.00
148_L151_L0.7621.00
93_R96_V0.7561.00
6_V9_I0.7471.00
4_L11_T0.7471.00
140_V146_P0.7461.00
39_T42_T0.7411.00
28_V32_R0.7361.00
32_R35_L0.7301.00
142_A149_A0.7291.00
59_L64_V0.7221.00
75_V78_E0.7191.00
67_L70_L0.7181.00
50_A126_L0.7151.00
100_F109_A0.7131.00
18_F100_F0.7131.00
112_L116_G0.7121.00
94_W133_V0.7121.00
119_G125_A0.7081.00
91_R95_L0.7021.00
75_V79_N0.6961.00
116_G125_A0.6911.00
44_A102_L0.6811.00
19_L37_T0.6751.00
1_Y116_G0.6731.00
60_P66_A0.6671.00
56_L59_L0.6631.00
143_A147_L0.6631.00
71_S100_F0.6631.00
39_T137_Q0.6621.00
36_K40_A0.6611.00
68_I71_S0.6561.00
15_H45_H0.6541.00
88_L92_R0.6541.00
147_L151_L0.6521.00
23_L37_T0.6491.00
3_R6_V0.6471.00
42_T137_Q0.6441.00
134_E137_Q0.6441.00
11_T16_L0.6411.00
28_V31_L0.6371.00
8_H45_H0.6181.00
23_L148_L0.6171.00
77_L82_F0.6131.00
135_L139_A0.6111.00
37_T93_R0.6081.00
37_T79_N0.6051.00
65_E68_I0.6031.00
42_T134_E0.5971.00
54_L123_L0.5961.00
53_A122_L0.5951.00
110_G114_E0.5941.00
35_L39_T0.5931.00
33_R37_T0.5911.00
94_W97_A0.5881.00
107_G110_G0.5871.00
111_A114_E0.5801.00
71_S103_I0.5781.00
74_Y89_T0.5771.00
24_L79_N0.5701.00
51_L59_L0.5681.00
115_L125_A0.5681.00
21_G78_E0.5621.00
19_L22_L0.5621.00
52_A109_A0.5571.00
98_F102_L0.5491.00
117_L120_G0.5481.00
51_L106_F0.5481.00
8_H39_T0.5481.00
8_H68_I0.5471.00
43_V46_S0.5471.00
41_F45_H0.5461.00
46_S108_F0.5421.00
43_V98_F0.5411.00
42_T65_E0.5371.00
52_A113_R0.5371.00
34_L141_V0.5361.00
35_L42_T0.5311.00
21_G24_L0.5301.00
46_S50_A0.5301.00
15_H68_I0.5291.00
24_L27_L0.5281.00
82_F86_P0.5271.00
81_R87_G0.5211.00
81_R86_P0.5201.00
23_L34_L0.5191.00
146_P151_L0.5171.00
136_G139_A0.5151.00
53_A117_L0.5131.00
10_L16_L0.5111.00
88_L91_R0.5081.00
117_L125_A0.5081.00
145_L150_L0.5061.00
120_G123_L0.5061.00
83_R87_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k0jA 3 0.8896 4.9 0.928 Contact Map
2kluA 1 0.2403 4.4 0.93 Contact Map
2m20A 2 0.1948 4.3 0.931 Contact Map
2l2tA 2 0.2403 3.8 0.932 Contact Map
3ne5A 3 0.974 3 0.936 Contact Map
1iijA 1 0.2273 2.9 0.936 Contact Map
2l9uA 2 0.2143 2.6 0.938 Contact Map
1tviA 1 0.3377 2.2 0.94 Contact Map
3w9iA 3 0.974 1.7 0.944 Contact Map
4mt1A 3 0.9545 1.7 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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