GREMLIN Database
Sigma_reg_C - Sigma factor regulator C-terminal
PFAM: PF13791 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (153)
Sequences: 778 (637)
Seq/√Len: 51.5
META: 0.447

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_D20_Y6.8681.00
21_T24_E4.3761.00
10_A137_T3.8191.00
136_P139_E3.3611.00
11_E155_G2.6981.00
41_V87_F2.4731.00
14_I133_V2.3481.00
115_K119_D2.3371.00
114_L118_L2.3321.00
38_W62_G2.1191.00
2_E141_L2.0771.00
16_F131_V2.0261.00
149_I152_A1.9491.00
138_E141_L1.9310.99
120_Y124_N1.8500.99
78_Y81_E1.8480.99
91_L94_L1.8390.99
28_L146_E1.7920.99
16_F20_Y1.7450.99
22_L84_E1.7250.99
38_W43_T1.7150.99
6_E138_E1.7020.99
92_K122_K1.6840.99
11_E132_V1.6610.98
135_G155_G1.6350.98
36_I39_Y1.6350.98
78_Y82_E1.6280.98
87_F91_L1.6240.98
44_G129_Y1.6080.98
76_E81_E1.6020.98
120_Y125_G1.5930.98
12_V140_L1.5340.97
13_A16_F1.5330.97
72_D75_K1.4640.96
39_Y42_D1.4550.96
121_L125_G1.4520.96
9_V136_P1.4200.96
2_E5_P1.3940.95
61_I91_L1.3560.94
15_S41_V1.3410.94
70_G73_D1.3340.94
11_E135_G1.3320.94
133_V140_L1.3270.94
86_H90_A1.3170.94
7_G143_L1.3060.93
40_W129_Y1.2840.93
21_T78_Y1.2730.92
11_E15_S1.2560.92
19_P129_Y1.2510.92
24_E27_K1.2470.91
107_D111_Y1.2310.91
114_L117_R1.2250.91
68_S74_P1.2060.90
14_I33_N1.1960.90
152_A155_G1.1910.89
12_V149_I1.1870.89
6_E28_L1.1620.88
134_T137_T1.1470.88
11_E20_Y1.1260.87
7_G120_Y1.1220.86
40_W132_V1.1210.86
118_L121_L1.1130.86
118_L122_K1.1110.86
13_A132_V1.1040.86
20_Y25_V1.0870.85
6_E9_V1.0850.85
77_K82_E1.0740.84
89_S93_Y1.0570.83
102_K109_D1.0490.83
89_S103_K1.0460.82
41_V126_V1.0410.82
43_T91_L1.0280.81
40_W125_G1.0240.81
9_V137_T1.0020.80
37_V63_F0.9920.79
61_I94_L0.9910.79
13_A40_W0.9880.79
77_K80_S0.9850.78
13_A155_G0.9840.78
10_A140_L0.9640.77
76_E79_P0.9600.77
34_L133_V0.9470.76
79_P82_E0.9450.75
13_A140_L0.9350.75
50_E53_K0.9240.74
4_L8_T0.9190.73
85_E150_R0.9160.73
100_F103_K0.9100.73
11_E83_R0.9000.72
127_K147_P0.8940.71
128_I150_R0.8910.71
85_E88_I0.8890.71
90_A93_Y0.8880.71
14_I131_V0.8800.70
110_G128_I0.8760.70
38_W149_I0.8750.70
86_H93_Y0.8710.69
40_W136_P0.8670.69
69_N72_D0.8660.69
132_V135_G0.8640.69
100_F104_L0.8580.68
22_L26_Q0.8540.68
20_Y128_I0.8400.66
39_Y65_P0.8390.66
44_G117_R0.8290.65
94_L126_V0.8200.65
29_L139_E0.8190.64
65_P90_A0.8050.63
108_L149_I0.8040.63
70_G74_P0.8020.63
20_Y155_G0.7820.61
5_P8_T0.7820.61
43_T154_L0.7810.61
38_W114_L0.7780.60
48_E51_E0.7750.60
83_R155_G0.7730.60
18_K27_K0.7720.60
25_V29_L0.7690.60
15_S129_Y0.7670.59
13_A122_K0.7620.59
97_N115_K0.7610.59
18_K24_E0.7590.59
10_A39_Y0.7580.58
92_K95_K0.7530.58
15_S135_G0.7530.58
42_D131_V0.7490.58
42_D132_V0.7370.56
14_I117_R0.7350.56
91_L118_L0.7340.56
16_F149_I0.7300.56
31_P139_E0.7300.56
2_E31_P0.7280.55
9_V37_V0.7250.55
121_L124_N0.7240.55
93_Y97_N0.7220.55
69_N74_P0.7200.55
87_F121_L0.7150.54
104_L107_D0.7140.54
103_K124_N0.7030.53
67_P72_D0.7010.53
41_V63_F0.7010.53
22_L39_Y0.6990.52
12_V152_A0.6980.52
55_I58_G0.6920.52
94_L98_E0.6910.52
92_K96_D0.6900.51
20_Y28_L0.6860.51
25_V131_V0.6860.51
36_I131_V0.6840.51
15_S47_D0.6740.50
87_F90_A0.6690.49
23_E46_E0.6660.49
29_L143_L0.6630.49
130_G140_L0.6570.48
40_W45_S0.6570.48
125_G129_Y0.6540.48
66_S70_G0.6540.48
139_E142_K0.6480.47
63_F126_V0.6430.47
49_D53_K0.6410.46
106_E109_D0.6310.45
8_T136_P0.6310.45
64_P114_L0.6250.45
65_P96_D0.6240.45
117_R120_Y0.6210.44
77_K81_E0.6200.44
11_E134_T0.6190.44
45_S49_D0.6170.44
103_K109_D0.6160.44
25_V28_L0.6160.44
105_A109_D0.6150.44
54_L57_E0.6140.44
31_P34_L0.6130.43
59_D124_N0.6120.43
7_G24_E0.6100.43
14_I152_A0.6090.43
34_L140_L0.6060.43
41_V128_I0.6000.42
41_V146_E0.6000.42
107_D110_G0.6000.42
69_N73_D0.5990.42
38_W134_T0.5930.41
92_K149_I0.5930.41
31_P155_G0.5900.41
37_V40_W0.5870.41
7_G136_P0.5850.41
125_G141_L0.5810.40
134_T144_K0.5800.40
45_S142_K0.5800.40
128_I132_V0.5770.40
22_L126_V0.5760.40
120_Y154_L0.5750.40
8_T137_T0.5740.40
25_V90_A0.5740.40
88_I95_K0.5720.39
51_E116_E0.5720.39
29_L134_T0.5680.39
116_E119_D0.5670.39
44_G124_N0.5660.39
61_I117_R0.5640.39
15_S42_D0.5610.38
74_P79_P0.5600.38
42_D150_R0.5540.38
33_N144_K0.5520.37
101_A140_L0.5490.37
68_S71_D0.5470.37
4_L129_Y0.5430.36
122_K125_G0.5400.36
2_E26_Q0.5390.36
114_L124_N0.5360.36
55_I59_D0.5350.36
117_R122_K0.5340.36
137_T153_S0.5330.36
14_I49_D0.5310.35
37_V134_T0.5310.35
36_I148_W0.5290.35
4_L114_L0.5280.35
141_L149_I0.5260.35
118_L124_N0.5250.35
36_I63_F0.5240.35
84_E141_L0.5200.34
13_A152_A0.5140.34
117_R125_G0.5120.34
101_A108_L0.5110.33
28_L126_V0.5110.33
94_L125_G0.5100.33
90_A125_G0.5070.33
48_E99_E0.5060.33
72_D89_S0.5050.33
137_T143_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q1zA 1 0.3269 15.9 0.92 Contact Map
3edyA 1 0.7308 14.8 0.921 Contact Map
4jwhA 1 0.8526 11.6 0.925 Contact Map
3whiA 2 0.391 9.5 0.928 Contact Map
2z30B 1 0.3718 8.9 0.929 Contact Map
3pmcA 2 0.4167 8.9 0.929 Contact Map
3o3mA 1 0.359 8.1 0.93 Contact Map
2ki0A 1 0.2115 7.8 0.931 Contact Map
3pmdA 2 0.4615 7.8 0.931 Contact Map
3afgA 1 0.5449 6.7 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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