GREMLIN Database
DUF4180 - Domain of unknown function (DUF4180)
PFAM: PF13788 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 112 (108)
Sequences: 3653 (2834)
Seq/√Len: 272.7
META: 0.84

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_E58_E3.2831.00
104_D107_E3.0171.00
36_R69_R2.8481.00
103_A107_E2.6961.00
27_G31_E2.4731.00
60_L89_F2.3751.00
17_D20_D2.3561.00
60_L99_I2.1621.00
54_G58_E2.1541.00
85_S88_D2.1351.00
28_A31_E1.9931.00
41_K78_K1.9761.00
50_D85_S1.9081.00
40_P43_N1.9051.00
91_Y95_R1.8491.00
23_D27_G1.7991.00
87_R91_Y1.7871.00
88_D91_Y1.7761.00
61_Q65_N1.7321.00
47_D50_D1.7271.00
84_K88_D1.7191.00
52_S85_S1.5081.00
16_R20_D1.5051.00
19_Q22_L1.4601.00
4_K33_G1.4431.00
105_L109_L1.4251.00
26_I29_A1.4101.00
106_E109_L1.4071.00
7_E105_L1.3581.00
48_F56_A1.3401.00
39_L70_L1.3311.00
89_F93_S1.3181.00
100_F111_R1.2991.00
49_F79_Y1.2851.00
38_I73_V1.2801.00
107_E110_E1.2781.00
64_V98_Q1.2701.00
76_F90_I1.2461.00
83_S86_L1.2381.00
97_R100_F1.2241.00
55_L59_I1.2151.00
41_K46_P1.1791.00
19_Q23_D1.1761.00
86_L90_I1.1681.00
38_I105_L1.1621.00
45_T55_L1.1611.00
102_V111_R1.1461.00
21_A63_F1.1461.00
7_E40_P1.1131.00
47_D53_T1.0991.00
37_I68_V1.0971.00
67_R98_Q1.0921.00
28_A32_T1.0901.00
25_L29_A1.0821.00
106_E110_E1.0581.00
63_F70_L1.0511.00
40_P105_L1.0501.00
36_R108_A1.0461.00
72_I99_I1.0381.00
18_E54_G1.0361.00
29_A35_D1.0141.00
90_I101_F1.0111.00
26_I68_V1.0031.00
3_V36_R0.9691.00
5_I109_L0.9521.00
12_G43_N0.8901.00
5_I38_I0.8881.00
36_R71_A0.8851.00
29_A68_V0.8811.00
10_S13_P0.8771.00
41_K79_Y0.8711.00
73_V102_V0.8661.00
15_I59_I0.8611.00
13_P16_R0.8591.00
3_V35_D0.8571.00
16_R45_T0.8521.00
96_G100_F0.8401.00
14_L43_N0.8361.00
47_D55_L0.8260.99
18_E55_L0.8210.99
84_K87_R0.8200.99
51_L92_E0.8180.99
102_V108_A0.8160.99
60_L93_S0.8100.99
102_V107_E0.8020.99
35_D67_R0.8000.99
76_F79_Y0.7690.99
44_L72_I0.7530.99
25_L68_V0.7490.99
35_D68_V0.7300.99
25_L63_F0.7270.99
10_S14_L0.7180.99
75_D78_K0.7170.99
26_I30_Y0.7120.98
73_V105_L0.7120.98
21_A59_I0.7060.98
93_S99_I0.6980.98
76_F86_L0.6920.98
29_A34_A0.6840.98
89_F97_R0.6780.98
26_I37_I0.6770.98
27_G30_Y0.6690.98
71_A100_F0.6670.98
89_F92_E0.6640.98
28_A34_A0.6620.98
61_Q64_V0.6550.97
3_V7_E0.6510.97
78_K82_T0.6490.97
69_R98_Q0.6450.97
50_D54_G0.6370.97
11_D42_E0.6370.97
63_F68_V0.6230.96
100_F108_A0.6180.96
61_Q93_S0.6170.96
8_V25_L0.6100.96
57_G65_N0.6100.96
40_P73_V0.6090.96
13_P43_N0.6070.96
86_L93_S0.6040.96
69_R100_F0.6020.96
22_L62_K0.6010.96
4_K13_P0.5950.95
20_D23_D0.5950.95
9_S13_P0.5930.95
63_F99_I0.5910.95
64_V67_R0.5880.95
64_V99_I0.5870.95
41_K76_F0.5800.95
74_G82_T0.5760.94
62_K66_Y0.5750.94
103_A110_E0.5730.94
94_N101_F0.5730.94
75_D79_Y0.5730.94
71_A108_A0.5680.94
8_V39_L0.5660.94
38_I71_A0.5610.94
93_S101_F0.5570.93
59_I63_F0.5560.93
38_I108_A0.5550.93
30_Y68_V0.5540.93
26_I31_E0.5500.93
15_I44_L0.5440.93
38_I45_T0.5430.93
18_E22_L0.5350.92
13_P44_L0.5340.92
23_D66_Y0.5320.92
79_Y82_T0.5320.92
26_I32_T0.5290.92
4_K7_E0.5280.92
65_N86_L0.5270.91
60_L70_L0.5250.91
23_D26_I0.5250.91
44_L49_F0.5230.91
55_L60_L0.5210.91
90_I94_N0.5140.90
30_Y35_D0.5130.90
30_Y33_G0.5090.90
25_L37_I0.5060.90
56_A59_I0.5040.90
82_T101_F0.5010.89
64_V96_G0.5010.89
22_L27_G0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bl4A 2 0.9018 82.6 0.878 Contact Map
2q3lA 2 0.9196 80.3 0.881 Contact Map
2ookA 2 0.9196 76.7 0.885 Contact Map
4xs5A 1 0.8929 66.2 0.893 Contact Map
2ka5A 1 0.8929 55.5 0.9 Contact Map
1th8B 1 0.8929 45.7 0.906 Contact Map
4qtpA 2 0.8839 45.6 0.906 Contact Map
2vg3A 2 0.9554 45.5 0.906 Contact Map
1h4xA 1 0.8839 45.5 0.906 Contact Map
4q9mA 2 0.9643 44.9 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0058 seconds.