GREMLIN Database
HXXEE - Protein of unknown function with HXXEE motif
PFAM: PF13787 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (110)
Sequences: 6825 (5582)
Seq/√Len: 532.2
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_F45_A3.2611.00
89_A99_L3.2561.00
77_L81_N2.2641.00
103_V108_P2.1811.00
46_L50_N2.1551.00
89_A96_S2.0181.00
6_A105_L2.0121.00
78_L81_N1.9901.00
13_E95_Y1.9581.00
42_L46_L1.8731.00
42_L45_A1.8661.00
17_G20_A1.8401.00
12_F16_I1.8381.00
9_L101_T1.6911.00
36_A40_E1.6551.00
35_L40_E1.6131.00
41_F44_A1.5831.00
6_A109_L1.5671.00
23_R26_R1.5471.00
19_P23_R1.5231.00
89_A94_G1.5211.00
7_Y11_Q1.5091.00
37_V40_E1.4941.00
77_L80_V1.4631.00
42_L50_N1.4371.00
87_L91_V1.4291.00
47_L50_N1.3901.00
49_V53_L1.3881.00
88_A96_S1.3741.00
21_W25_N1.3311.00
48_V52_L1.3261.00
84_F88_A1.3211.00
20_A24_R1.3061.00
50_N54_V1.3011.00
35_L38_A1.2891.00
82_G107_L1.2691.00
72_L75_A1.2621.00
22_L25_N1.2551.00
46_L49_V1.2491.00
18_F23_R1.2491.00
95_Y100_V1.2481.00
45_A49_V1.2171.00
18_F21_W1.2011.00
53_L56_L1.1881.00
4_P8_A1.1821.00
62_L65_P1.1781.00
99_L103_V1.1731.00
71_G74_L1.1331.00
11_Q15_Y1.1091.00
49_V52_L1.0911.00
79_L110_G1.0891.00
44_A47_L1.0691.00
18_F22_L1.0641.00
47_L51_A1.0581.00
44_A48_V1.0501.00
86_I90_I1.0471.00
20_A23_R1.0451.00
86_I103_V1.0441.00
106_F109_L1.0341.00
21_W24_R1.0301.00
3_L75_A1.0251.00
40_E44_A1.0251.00
19_P25_N1.0241.00
61_A64_G1.0131.00
36_A39_E1.0091.00
41_F50_N1.0091.00
43_L47_L1.0071.00
88_A92_L0.9871.00
45_A52_L0.9741.00
61_A65_P0.9721.00
42_L53_L0.9591.00
48_V51_A0.9571.00
60_A64_G0.9521.00
22_L28_L0.9371.00
59_L62_L0.9221.00
52_L55_W0.9111.00
21_W97_P0.9081.00
82_G103_V0.9051.00
11_Q102_A0.8891.00
48_V55_W0.8741.00
17_G21_W0.8741.00
45_A48_V0.8741.00
101_T106_F0.8701.00
60_A63_R0.8681.00
51_A54_V0.8631.00
19_P22_L0.8521.00
52_L56_L0.8501.00
22_L27_P0.8441.00
47_L54_V0.8411.00
73_A77_L0.8311.00
63_R66_R0.8241.00
58_Y61_A0.8211.00
33_F37_V0.8191.00
25_N28_L0.8111.00
38_A41_F0.8001.00
35_L39_E0.7911.00
71_G75_A0.7901.00
46_L51_A0.7741.00
51_A55_W0.7631.00
25_N29_P0.7601.00
43_L46_L0.7571.00
22_L26_R0.7571.00
42_L52_L0.7541.00
45_A51_A0.7541.00
88_A91_V0.7381.00
45_A53_L0.7361.00
63_R71_G0.7341.00
8_A12_F0.7281.00
3_L6_A0.7271.00
23_R28_L0.7021.00
59_L63_R0.7011.00
84_F96_S0.7011.00
96_S99_L0.6951.00
64_G67_A0.6921.00
41_F49_V0.6911.00
89_A92_L0.6771.00
11_Q106_F0.6701.00
19_P26_R0.6671.00
47_L52_L0.6531.00
70_L74_L0.6451.00
98_G102_A0.6441.00
67_A72_L0.6441.00
3_L109_L0.6411.00
46_L53_L0.6371.00
83_L87_L0.6371.00
50_N53_L0.6281.00
95_Y99_L0.6271.00
62_L67_A0.6231.00
21_W26_R0.6231.00
41_F46_L0.6171.00
46_L56_L0.6151.00
23_R27_P0.6101.00
19_P27_P0.6091.00
40_E45_A0.6021.00
12_F15_Y0.5991.00
18_F26_R0.5951.00
75_A110_G0.5951.00
41_F51_A0.5941.00
105_L108_P0.5921.00
58_Y62_L0.5921.00
5_L8_A0.5910.99
11_Q84_F0.5880.99
46_L57_A0.5840.99
86_I102_A0.5800.99
69_W73_A0.5780.99
24_R27_P0.5690.99
75_A81_N0.5650.99
59_L64_G0.5630.99
39_E42_L0.5620.99
66_R70_L0.5500.99
42_L49_V0.5490.99
68_P71_G0.5470.99
33_F36_A0.5450.99
17_G22_L0.5440.99
64_G69_W0.5420.99
76_A80_V0.5400.99
60_A66_R0.5310.99
8_A11_Q0.5280.99
65_P68_P0.5190.99
13_E101_T0.5160.99
11_Q96_S0.5130.99
41_F48_V0.5050.98
43_L50_N0.5020.98
39_E45_A0.5000.98
40_E43_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v54M 1 0.1593 3.2 0.904 Contact Map
1qp2A 1 0.2124 1 0.927 Contact Map
2ksfA 1 0.6018 1 0.927 Contact Map
3wmmA 3 0.3097 0.5 0.941 Contact Map
3iszA 2 0.3274 0.5 0.943 Contact Map
2i68A 2 0.4602 0.5 0.943 Contact Map
2jr1A 1 0.2478 0.5 0.943 Contact Map
3h3gB 1 0.1062 0.5 0.944 Contact Map
2qyvA 2 0.3363 0.4 0.947 Contact Map
1jqgA 1 0.2832 0.4 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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