GREMLIN Database
DUF4178 - Domain of unknown function (DUF4178)
PFAM: PF13785 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 137 (132)
Sequences: 7992 (5841)
Seq/√Len: 508.4
META: 0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_R115_R3.2091.00
9_D133_E3.0491.00
71_T78_T2.8351.00
7_T12_D2.7211.00
5_R12_D2.6901.00
30_N45_E2.6541.00
5_R14_E2.6471.00
15_V34_L2.4351.00
20_Q30_N2.2551.00
11_V39_S2.2541.00
119_I129_W2.2491.00
73_T78_T2.0851.00
22_S88_T1.8841.00
18_R30_N1.8811.00
17_G93_G1.8801.00
86_A90_V1.8711.00
85_A89_Y1.8391.00
81_V106_A1.8221.00
32_Y45_E1.7701.00
16_I35_Y1.6961.00
20_Q28_F1.6851.00
77_R110_A1.6631.00
22_S28_F1.6461.00
7_T10_G1.6221.00
87_A90_V1.6091.00
87_A91_G1.6001.00
115_R133_E1.5791.00
84_R104_R1.5401.00
104_R121_Y1.5071.00
75_D131_L1.4701.00
34_L43_L1.4661.00
86_A102_T1.4081.00
23_Y27_Y1.3911.00
84_R91_G1.3861.00
54_L57_W1.3791.00
119_I127_P1.3681.00
36_D39_S1.3541.00
85_A91_G1.3521.00
121_Y127_P1.3271.00
85_A105_V1.3101.00
18_R32_Y1.2311.00
51_E54_L1.2281.00
56_F59_P1.2241.00
11_V36_D1.2221.00
115_R131_L1.2111.00
53_V56_F1.2061.00
105_V108_Y1.1901.00
79_Y117_L1.1811.00
52_Y55_S1.1681.00
33_L42_W1.1621.00
79_Y131_L1.1501.00
51_E55_S1.1471.00
101_E105_V1.1331.00
41_R56_F1.1131.00
106_A119_I1.1061.00
58_S62_P1.0841.00
93_G97_V1.0601.00
107_D111_P1.0601.00
60_V63_L1.0591.00
84_R88_T1.0461.00
95_W100_G1.0441.00
18_R92_E1.0431.00
82_F109_V1.0381.00
19_L42_W1.0291.00
11_V38_R1.0271.00
103_V108_Y1.0231.00
107_D118_S1.0151.00
88_T91_G1.0031.00
79_Y115_R0.9931.00
92_E95_W0.9801.00
37_G40_G0.9761.00
71_T80_R0.9741.00
57_W60_V0.9661.00
97_V100_G0.9591.00
59_P62_P0.9571.00
85_A88_T0.9381.00
49_Q53_V0.9351.00
77_R113_G0.9341.00
103_V109_V0.9311.00
36_D40_G0.9161.00
61_P64_P0.9061.00
93_G96_P0.9031.00
52_Y57_W0.9001.00
101_E108_Y0.8981.00
62_P65_P0.8881.00
53_V57_W0.8851.00
117_L129_W0.8831.00
112_P115_R0.8791.00
35_Y40_G0.8781.00
108_Y111_P0.8721.00
22_S90_V0.8621.00
52_Y56_F0.8571.00
61_P65_P0.8551.00
51_E56_F0.8431.00
106_A121_Y0.8291.00
86_A91_G0.8271.00
4_T15_V0.8041.00
67_R70_Q0.8031.00
23_Y26_G0.8031.00
85_A90_V0.7991.00
5_R38_R0.7961.00
19_L89_Y0.7881.00
33_L94_E0.7831.00
73_T76_G0.7811.00
103_V110_A0.7791.00
28_F88_T0.7761.00
101_E104_R0.7711.00
116_F134_Y0.7631.00
116_F132_G0.7621.00
109_V134_Y0.7611.00
49_Q55_S0.7601.00
56_F62_P0.7591.00
2_L16_I0.7561.00
44_S132_G0.7551.00
57_W61_P0.7541.00
27_Y83_E0.7531.00
110_A115_R0.7501.00
49_Q56_F0.7501.00
80_R83_E0.7451.00
103_V111_P0.7401.00
123_G128_T0.7361.00
98_R101_E0.7351.00
105_V109_V0.7351.00
13_F39_S0.7271.00
81_V84_R0.7271.00
23_Y105_V0.7271.00
51_E57_W0.7261.00
84_R89_Y0.7261.00
43_L54_L0.7241.00
46_E83_E0.7201.00
33_L39_S0.7141.00
14_E35_Y0.7131.00
63_L66_A0.7101.00
117_L131_L0.7091.00
114_G133_E0.6991.00
102_T108_Y0.6941.00
42_W94_E0.6801.00
22_S86_A0.6771.00
100_G103_V0.6731.00
54_L59_P0.6711.00
45_E48_D0.6661.00
19_L93_G0.6651.00
122_S125_G0.6621.00
122_S128_T0.6531.00
58_S63_L0.6501.00
35_Y38_R0.6451.00
29_W42_W0.6441.00
8_Y56_F0.6401.00
54_L60_V0.6381.00
121_Y125_G0.6271.00
9_D13_F0.6231.00
13_F41_R0.6231.00
11_V40_G0.6191.00
8_Y13_F0.6111.00
51_E134_Y0.6091.00
16_I33_L0.6040.99
68_P72_V0.6030.99
60_V65_P0.5990.99
73_T77_R0.5980.99
74_Y117_L0.5940.99
86_A89_Y0.5890.99
6_G34_L0.5880.99
38_R41_R0.5780.99
49_Q52_Y0.5780.99
41_R58_S0.5740.99
51_E61_P0.5740.99
75_D115_R0.5720.99
112_P134_Y0.5720.99
102_T111_P0.5710.99
42_W130_S0.5670.99
111_P114_G0.5630.99
18_R89_Y0.5610.99
2_L92_E0.5610.99
107_D110_A0.5600.99
103_V107_D0.5560.99
57_W132_G0.5540.99
31_E118_S0.5540.99
37_G41_R0.5490.99
19_L95_W0.5490.99
6_G15_V0.5480.99
23_Y83_E0.5420.99
12_D37_G0.5400.99
19_L87_A0.5390.99
56_F64_P0.5380.99
23_Y85_A0.5360.99
82_F134_Y0.5300.99
84_R87_A0.5260.99
84_R90_V0.5210.99
105_V110_A0.5210.99
62_P66_A0.5200.98
33_L40_G0.5190.98
95_W98_R0.5140.98
59_P65_P0.5130.98
60_V64_P0.5120.98
55_S58_S0.5060.98
77_R114_G0.5020.98
60_V74_Y0.5010.98
8_Y11_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h43A 5 0.1679 20.5 0.883 Contact Map
2ls01 1 0.3869 16.5 0.888 Contact Map
2wfwA 3 0.6715 7.9 0.903 Contact Map
2oaiA 2 0.2263 7.8 0.903 Contact Map
1k0hA 1 0.3066 6.4 0.907 Contact Map
3er0A 1 0.9124 4.5 0.913 Contact Map
2f9hA 2 0.4818 3.9 0.916 Contact Map
2kz4A 1 0.2774 3.8 0.917 Contact Map
1ah9A 1 0.1752 3.2 0.919 Contact Map
1ed7A 1 0.2701 3.1 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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