GREMLIN Database
DUF4177 - Domain of unknown function (DUF4177)
PFAM: PF13783 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 65 (61)
Sequences: 6522 (4614)
Seq/√Len: 590.7
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_E63_K4.8241.00
4_K33_L2.9161.00
2_E64_R2.2961.00
41_V63_K2.1081.00
40_L60_L2.0861.00
29_V33_L1.9891.00
29_V32_E1.9451.00
40_L62_F1.8591.00
7_T57_E1.7041.00
43_I61_I1.6141.00
32_E36_E1.5991.00
30_L34_G1.5731.00
30_L60_L1.4751.00
33_L36_E1.4651.00
43_I60_L1.4221.00
6_V33_L1.4021.00
1_W39_E1.3911.00
5_V30_L1.3381.00
21_E25_D1.2691.00
20_P24_E1.2581.00
22_K25_D1.2351.00
34_G63_K1.2111.00
34_G39_E1.1991.00
1_W65_E1.1961.00
5_V31_N1.0871.00
40_L61_I1.0701.00
49_S52_F1.0671.00
1_W63_K1.0571.00
40_L43_I1.0371.00
6_V29_V1.0311.00
44_F59_V1.0001.00
6_V62_F0.9951.00
45_P48_G0.9891.00
1_W42_S0.9391.00
50_G54_G0.9211.00
5_V24_E0.9201.00
48_G51_G0.9101.00
32_E35_A0.9101.00
42_S61_I0.8851.00
44_F61_I0.8771.00
10_E13_F0.8681.00
30_L62_F0.8631.00
34_G40_L0.8551.00
44_F58_I0.8551.00
4_K24_E0.8451.00
52_F55_T0.8411.00
52_F57_E0.8271.00
23_L60_L0.8261.00
19_D22_K0.8241.00
51_G54_G0.8221.00
8_V29_V0.8181.00
51_G55_T0.7931.00
9_K12_G0.7521.00
34_G41_V0.7251.00
4_K36_E0.7201.00
49_S55_T0.7181.00
1_W34_G0.7011.00
18_F21_E0.6961.00
3_Y34_G0.6871.00
19_D23_L0.6701.00
54_G57_E0.6631.00
48_G55_T0.6571.00
50_G56_E0.6351.00
31_N34_G0.6281.00
25_D32_E0.6241.00
19_D24_E0.6221.00
47_D50_G0.6201.00
4_K62_F0.6141.00
31_N35_A0.6041.00
8_V60_L0.5981.00
55_T58_I0.5971.00
56_E59_V0.5871.00
30_L59_V0.5831.00
40_L44_F0.5711.00
17_K20_P0.5671.00
33_L62_F0.5610.99
5_V59_V0.5610.99
50_G53_G0.5600.99
14_G22_K0.5560.99
15_G18_F0.5540.99
43_I59_V0.5530.99
50_G55_T0.5480.99
48_G54_G0.5420.99
38_W65_E0.5380.99
2_E31_N0.5340.99
3_Y63_K0.5230.99
5_V61_I0.5120.99
23_L61_I0.5050.99
48_G56_E0.5030.99
1_W37_G0.5030.99
10_E51_G0.5030.99
30_L33_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jg5A 3 0.6154 37 0.782 Contact Map
1qb3A 2 0.9692 18.4 0.812 Contact Map
3qy2A 4 0.9692 15.4 0.818 Contact Map
1pucA 2 0.9692 14.6 0.82 Contact Map
4yc6B 1 0.8308 7.8 0.841 Contact Map
1cksA 5 0.8308 6.5 0.846 Contact Map
4tvpG 3 0.3385 5 0.854 Contact Map
4ui9E 1 0.7538 4.4 0.858 Contact Map
4kgnA 2 0.9692 4.1 0.86 Contact Map
4hgzA 4 1 4 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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