GREMLIN Database
SpoVAB - Stage V sporulation protein AB
PFAM: PF13782 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (109)
Sequences: 1010 (765)
Seq/√Len: 73.3
META: 0.665

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_T23_Y7.9791.00
14_T23_Y4.2051.00
54_F58_A4.0441.00
7_I27_I3.2101.00
102_A106_F2.5911.00
46_L50_L2.3761.00
1_L31_G2.3131.00
36_L42_I2.0431.00
105_L109_L1.9481.00
101_V104_S1.8311.00
31_G67_A1.7641.00
47_G50_L1.7221.00
34_G38_S1.7221.00
5_G38_S1.7191.00
13_L68_A1.6351.00
67_A70_A1.5750.99
101_V105_L1.5720.99
3_V65_L1.5590.99
4_L68_A1.5130.99
10_L64_C1.4460.99
4_L75_V1.4420.99
5_G34_G1.4370.99
98_L102_A1.4310.99
66_A96_I1.4160.99
33_L37_L1.3890.98
9_R12_Q1.3750.98
48_P57_F1.3490.98
98_L101_V1.3060.98
55_G83_I1.2750.97
67_A93_I1.2610.97
49_I53_I1.2330.97
7_I11_A1.2320.97
36_L40_F1.2280.96
79_L83_I1.2110.96
72_V75_V1.1760.96
44_L47_G1.1730.95
50_L73_L1.1560.95
96_I100_K1.1360.95
33_L52_I1.1330.94
24_E82_R1.1150.94
27_I66_A1.0870.93
25_W28_I1.0710.93
11_A24_E1.0660.92
10_L67_A1.0640.92
26_A37_L1.0440.92
35_T38_S1.0380.91
94_L98_L1.0260.91
43_S55_G1.0090.90
37_L98_L0.9750.89
24_E34_G0.9680.88
17_A107_Y0.9680.88
33_L98_L0.9660.88
64_C108_W0.9620.88
76_I93_I0.9430.87
49_I52_I0.9420.87
3_V76_I0.9400.87
21_R25_W0.9370.87
34_G82_R0.9320.86
24_E31_G0.9310.86
13_L67_A0.9230.86
104_S108_W0.9180.86
34_G58_A0.9170.85
6_I23_Y0.9150.85
35_T40_F0.9140.85
90_G94_L0.9050.85
32_I35_T0.9040.85
61_F104_S0.8920.84
26_A78_I0.8880.84
55_G62_V0.8830.83
26_A30_G0.8560.81
25_W29_L0.8490.81
37_L41_D0.8480.81
36_L49_I0.8430.80
2_T108_W0.8340.80
8_P65_L0.8330.79
64_C70_A0.8270.79
13_L64_C0.8150.78
50_L89_L0.8130.78
84_G101_V0.8110.78
61_F66_A0.8100.78
61_F96_I0.8050.77
55_G106_F0.7930.76
24_E62_V0.7890.76
34_G103_G0.7880.76
95_A104_S0.7860.75
32_I37_L0.7810.75
47_G53_I0.7710.74
38_S62_V0.7590.73
33_L41_D0.7520.72
58_A86_K0.7510.72
49_I84_G0.7420.71
15_K26_A0.7370.71
90_G93_I0.7330.70
2_T96_I0.7250.69
45_P50_L0.7160.68
3_V96_I0.7110.68
96_I106_F0.7100.68
83_I86_K0.7060.67
87_R90_G0.7040.67
4_L65_L0.7030.67
76_I97_A0.7000.67
47_G54_F0.6960.66
48_P102_A0.6930.66
5_G96_I0.6910.66
15_K29_L0.6880.65
1_L84_G0.6770.64
73_L85_L0.6730.64
28_I95_A0.6730.64
10_L66_A0.6720.63
13_L66_A0.6720.63
10_L65_L0.6700.63
16_T20_I0.6690.63
78_I97_A0.6670.63
43_S102_A0.6650.63
87_R108_W0.6600.62
77_P103_G0.6540.61
32_I45_P0.6540.61
1_L75_V0.6480.61
72_V77_P0.6430.60
30_G34_G0.6350.59
10_L85_L0.6300.59
17_A109_L0.6200.57
6_I65_L0.6150.57
105_L108_W0.6130.56
8_P12_Q0.6100.56
70_A77_P0.6010.55
48_P53_I0.6000.55
71_E100_K0.5960.54
31_G91_Y0.5920.54
8_P13_L0.5840.53
49_I54_F0.5750.52
13_L97_A0.5720.51
51_L55_G0.5610.50
46_L73_L0.5610.50
99_G103_G0.5600.50
33_L87_R0.5590.50
5_G64_C0.5580.50
22_L26_A0.5570.50
47_G88_G0.5510.49
26_A61_F0.5460.48
78_I82_R0.5450.48
27_I78_I0.5450.48
8_P81_R0.5440.48
22_L25_W0.5410.48
68_A75_V0.5400.47
58_A62_V0.5390.47
25_W51_L0.5390.47
45_P53_I0.5370.47
26_A36_L0.5360.47
11_A17_A0.5340.47
64_C109_L0.5340.47
68_A72_V0.5330.47
1_L38_S0.5320.46
67_A72_V0.5300.46
84_G87_R0.5280.46
33_L42_I0.5240.45
35_T39_L0.5210.45
19_H51_L0.5200.45
65_L73_L0.5140.44
33_L43_S0.5130.44
66_A72_V0.5110.44
52_I55_G0.5090.44
46_L109_L0.5040.43
84_G91_Y0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.945 21.9 0.917 Contact Map
3l1lA 2 0.7706 13.7 0.924 Contact Map
2zy9A 2 0.945 13 0.925 Contact Map
2nwlA 3 0.7615 11.9 0.926 Contact Map
3orgA 2 0.5963 6.8 0.934 Contact Map
4u9nA 2 0.9541 6.7 0.934 Contact Map
4djkA 2 0.7248 6.2 0.935 Contact Map
4m64A 1 0.945 5.7 0.936 Contact Map
4j05A 3 0.9541 5.6 0.937 Contact Map
4ikvA 1 0.9083 5.4 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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