GREMLIN Database
DoxX_3 - DoxX-like family
PFAM: PF13781 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (101)
Sequences: 6051 (4630)
Seq/√Len: 460.7
META: 0.899

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G46_I3.1241.00
5_L49_G2.8321.00
51_W61_A2.6661.00
77_T84_W2.4331.00
35_R39_I2.2341.00
44_L68_L2.1521.00
66_I98_L2.0111.00
33_L36_L1.8901.00
3_V96_P1.8411.00
6_Y92_V1.7981.00
19_R22_A1.7491.00
71_G75_G1.7401.00
48_L65_Q1.7201.00
7_T11_S1.7161.00
26_R82_E1.7041.00
84_W91_L1.6871.00
21_L35_R1.6421.00
69_I94_N1.5671.00
30_P34_A1.5451.00
76_A91_L1.5331.00
6_Y10_V1.5191.00
90_P94_N1.5011.00
22_A26_R1.4691.00
97_I101_A1.4371.00
5_L46_I1.4231.00
73_T94_N1.3721.00
4_W65_Q1.3641.00
60_L63_L1.3501.00
96_P99_A1.3381.00
94_N97_I1.3231.00
51_W55_R1.3161.00
66_I101_A1.3141.00
7_T92_V1.3011.00
89_G93_K1.2951.00
48_L61_A1.2811.00
22_A25_A1.2781.00
61_A65_Q1.2731.00
96_P100_L1.2541.00
55_R58_P1.2411.00
36_L39_I1.2071.00
98_L101_A1.2011.00
2_L6_Y1.2001.00
51_W54_S1.1561.00
8_G12_K1.1321.00
21_L25_A1.1291.00
30_P33_L1.1161.00
10_V16_P1.1091.00
65_Q69_I1.1091.00
52_I62_A1.0981.00
69_I97_I1.0861.00
57_R60_L1.0821.00
63_L67_A1.0801.00
31_G34_A1.0581.00
36_L40_A1.0471.00
45_D72_Y1.0351.00
27_A75_G1.0341.00
73_T77_T1.0271.00
44_L47_A1.0201.00
15_Y21_L1.0181.00
39_I43_L1.0021.00
75_G79_L0.9741.00
26_R81_P0.9741.00
9_L14_L0.9601.00
86_D90_P0.9601.00
69_I98_L0.9561.00
69_I73_T0.9291.00
40_A44_L0.9231.00
70_L74_L0.8881.00
94_N98_L0.8821.00
48_L64_A0.8821.00
44_L48_L0.8811.00
52_I65_Q0.8641.00
25_A31_G0.8571.00
38_L41_G0.8501.00
27_A79_L0.8481.00
72_Y76_A0.8421.00
52_I58_P0.8371.00
86_D93_K0.8271.00
66_I70_L0.8241.00
83_L86_D0.8241.00
64_A68_L0.8221.00
65_Q101_A0.8101.00
97_I100_L0.8051.00
41_G45_D0.8021.00
5_L9_L0.7941.00
73_T76_A0.7821.00
86_D89_G0.7821.00
31_G35_R0.7801.00
80_L83_L0.7681.00
76_A80_L0.7451.00
48_L68_L0.7451.00
43_L47_A0.7371.00
58_P62_A0.7361.00
1_A53_L0.7301.00
14_L17_V0.7261.00
24_L38_L0.7211.00
59_R63_L0.7161.00
12_K42_G0.7061.00
76_A83_L0.7051.00
25_A34_A0.7051.00
32_A36_L0.6941.00
49_G53_L0.6911.00
17_V21_L0.6901.00
32_A35_R0.6741.00
73_T90_P0.6681.00
29_L37_L0.6651.00
12_K43_L0.6611.00
62_A101_A0.6531.00
72_Y75_G0.6501.00
67_A71_G0.6491.00
61_A64_A0.6471.00
34_A38_L0.6461.00
17_V20_E0.6441.00
90_P97_I0.6431.00
13_L16_P0.6371.00
88_F91_L0.6340.99
62_A66_I0.6340.99
91_L94_N0.6340.99
89_G92_V0.6320.99
21_L34_A0.6310.99
7_T93_K0.6280.99
50_L54_S0.6160.99
12_K45_D0.6100.99
15_Y18_P0.6060.99
11_S42_G0.6060.99
70_L98_L0.6010.99
26_R80_L0.5980.99
2_L92_V0.5970.99
11_S38_L0.5950.99
25_A28_G0.5860.99
60_L64_A0.5850.99
1_A8_G0.5830.99
65_Q68_L0.5760.99
7_T89_G0.5710.99
77_T91_L0.5670.99
85_L92_V0.5660.99
27_A82_E0.5440.98
21_L38_L0.5440.98
7_T20_E0.5440.98
93_K96_P0.5410.98
16_P20_E0.5370.98
30_P35_R0.5320.98
53_L57_R0.5220.98
92_V96_P0.5220.98
13_L46_I0.5200.98
52_I61_A0.5130.98
39_I56_R0.5110.98
74_L78_L0.5090.98
87_P90_P0.5090.98
6_Y12_K0.5080.98
62_A100_L0.5000.97
77_T81_P0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u5rA 3 0.4216 1 0.935 Contact Map
2k9pA 1 0.7353 0.9 0.937 Contact Map
4j2jD 1 0.1373 0.8 0.938 Contact Map
4twkA 2 0.3235 0.8 0.94 Contact Map
2nwlA 3 0.4216 0.7 0.94 Contact Map
1fftB 1 0.2059 0.7 0.941 Contact Map
4hygA 3 0.951 0.7 0.943 Contact Map
3qhoA 1 0.2843 0.7 0.943 Contact Map
1z96A 1 0.3725 0.6 0.943 Contact Map
1ajoA 1 0.3725 0.6 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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