GREMLIN Database
DUF4176 - Domain of unknown function (DUF4176)
PFAM: PF13780 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (73)
Sequences: 1690 (1435)
Seq/√Len: 167.9
META: 0.77

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R71_E4.1551.00
64_E67_Q3.4201.00
15_K42_E2.9971.00
16_K68_D2.9831.00
21_G36_S2.4041.00
37_G53_F2.3181.00
11_K59_E1.9531.00
20_I44_N1.9331.00
16_K62_V1.9231.00
9_L60_E1.8501.00
26_D33_Y1.7091.00
67_Q72_E1.6771.00
69_E72_E1.6751.00
9_L59_E1.6001.00
46_G49_Q1.5031.00
9_L62_V1.4861.00
63_F66_Y1.4791.00
9_L16_K1.4121.00
26_D29_E1.3991.00
17_L51_Y1.3861.00
20_I38_C1.3801.00
67_Q71_E1.3621.00
10_L13_G1.2941.00
18_M38_C1.2701.00
33_Y54_N1.2391.00
16_K66_Y1.2211.00
6_S64_E1.1821.00
2_L6_S1.1781.00
16_K70_E1.1611.00
4_I18_M1.1191.00
20_I36_S1.0520.99
20_I50_T1.0420.99
13_G17_L1.0290.99
40_Y66_Y1.0190.99
34_D54_N0.9980.99
33_Y57_D0.9910.99
20_I24_Q0.9770.99
25_I30_G0.9750.99
25_I32_I0.9350.99
24_Q36_S0.9310.99
4_I22_R0.9260.99
27_E30_G0.9220.99
26_D52_L0.9110.98
31_K54_N0.9080.98
44_N50_T0.9080.98
38_C50_T0.8930.98
39_L51_Y0.8860.98
21_G24_Q0.8660.98
69_E73_E0.8660.98
24_Q52_L0.8460.97
21_G70_E0.8420.97
36_S50_T0.8250.97
19_I37_G0.8220.97
20_I49_Q0.8070.97
8_V53_F0.8060.97
9_L13_G0.7810.96
8_V17_L0.7460.95
9_L14_T0.7370.94
23_K32_I0.7290.94
15_K70_E0.7070.93
10_L53_F0.7060.93
10_L17_L0.6940.92
56_E59_E0.6920.92
7_V62_V0.6910.92
17_L37_G0.6810.92
45_I49_Q0.6610.90
42_E45_I0.6560.90
27_E32_I0.6520.90
19_I53_F0.6470.90
21_G34_D0.6460.89
11_K33_Y0.6400.89
60_E66_Y0.6390.89
26_D32_I0.6380.89
4_I21_G0.6360.89
23_K49_Q0.6350.89
63_F71_E0.6310.88
24_Q44_N0.6300.88
28_G31_K0.6280.88
36_S44_N0.6270.88
64_E72_E0.6230.88
11_K29_E0.5990.86
22_R52_L0.5970.85
42_E70_E0.5960.85
61_V72_E0.5930.85
34_D55_H0.5930.85
44_N49_Q0.5770.83
3_P64_E0.5750.83
40_Y58_I0.5700.83
2_L5_G0.5700.83
62_V66_Y0.5690.83
1_L55_H0.5670.82
62_V67_Q0.5660.82
12_G42_E0.5630.82
20_I23_K0.5570.81
62_V68_D0.5550.81
6_S18_M0.5520.81
6_S63_F0.5510.81
10_L51_Y0.5460.80
11_K73_E0.5440.80
4_I20_I0.5430.80
70_E73_E0.5410.79
36_S49_Q0.5360.79
4_I14_T0.5320.78
26_D31_K0.5320.78
38_C44_N0.5300.78
25_I49_Q0.5240.77
4_I7_V0.5110.75
1_L52_L0.5050.75
46_G60_E0.5010.74
8_V37_G0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t6aA 1 1 11 0.886 Contact Map
3tlaA 2 0.3378 6.5 0.897 Contact Map
4jvoA 2 0.3378 6.1 0.899 Contact Map
3g1jA 1 0.9054 4.7 0.904 Contact Map
4mp8A 2 0.3649 4.4 0.905 Contact Map
1qc6A 2 0.9324 4.1 0.906 Contact Map
1h7nA 5 0.4054 4 0.907 Contact Map
4anoA 1 0.8919 3.4 0.91 Contact Map
4annA 1 0.8784 3.3 0.911 Contact Map
2c1wA 1 0.5541 3.1 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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