GREMLIN Database
DUF4173 - Domain of unknown function (DUF4173)
PFAM: PF13777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 190 (187)
Sequences: 6618 (4895)
Seq/√Len: 357.9
META: 0.888

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_R43_E3.2721.00
78_G130_L3.1901.00
124_L139_A2.7821.00
157_D182_S2.7811.00
107_L111_V2.7261.00
99_I112_L2.6481.00
106_R157_D2.5941.00
158_A162_R2.5091.00
111_V115_M2.4151.00
95_M112_L2.3441.00
154_V159_L2.2301.00
173_L178_L2.2111.00
95_M111_V2.1901.00
38_R42_F2.0731.00
78_G126_L2.0321.00
81_I122_L1.9841.00
55_L77_A1.9571.00
104_L163_Y1.9381.00
33_Y102_Y1.8441.00
120_V143_A1.8431.00
75_V79_L1.8161.00
4_N83_L1.7791.00
146_V150_A1.7721.00
4_N80_L1.7671.00
51_A84_T1.7651.00
117_W143_A1.7551.00
121_G140_A1.7351.00
88_L119_A1.7351.00
166_A169_E1.7221.00
162_R188_A1.7101.00
3_L54_L1.7081.00
71_R75_V1.6811.00
117_W144_A1.6781.00
114_F118_L1.6591.00
170_G173_L1.6501.00
93_L96_R1.6171.00
72_L75_V1.5561.00
90_S94_R1.5521.00
106_R160_I1.5311.00
95_M115_M1.5141.00
161_A185_A1.5011.00
67_A71_R1.4991.00
34_A102_Y1.4951.00
92_L112_L1.4871.00
113_V147_V1.4781.00
7_F51_A1.4741.00
33_Y101_A1.4641.00
123_V127_V1.4581.00
161_A165_V1.3991.00
113_V151_L1.3901.00
81_I126_L1.3431.00
96_R100_D1.3241.00
136_L140_A1.3201.00
109_L159_L1.3181.00
99_I163_Y1.3101.00
93_L97_L1.3091.00
80_L87_L1.3021.00
109_L156_P1.2971.00
163_Y166_A1.2961.00
99_I104_L1.2951.00
85_L119_A1.2891.00
4_N8_L1.2631.00
176_A179_A1.2561.00
11_V83_L1.2491.00
55_L81_I1.2431.00
162_R166_A1.2381.00
183_A186_V1.2361.00
4_N76_L1.2301.00
155_N158_A1.2151.00
155_N184_D1.2081.00
85_L89_A1.2041.00
111_V114_F1.1951.00
52_L122_L1.1861.00
73_L77_A1.1801.00
110_Y151_L1.1661.00
165_V169_E1.1581.00
158_A188_A1.1521.00
163_Y167_R1.1451.00
120_V147_V1.1431.00
48_A122_L1.1421.00
25_V28_P1.1361.00
174_D177_Y1.1251.00
35_E39_R1.1191.00
104_L112_L1.1111.00
161_A188_A1.1081.00
148_L152_N1.1031.00
34_A38_R1.1011.00
8_L83_L1.0711.00
5_L9_L1.0651.00
19_F90_S1.0631.00
85_L123_V1.0561.00
176_A180_S1.0481.00
11_V87_L1.0421.00
96_R112_L1.0411.00
8_L12_A1.0281.00
117_W147_V1.0241.00
4_N79_L1.0191.00
42_F46_A1.0181.00
23_A27_L1.0161.00
16_A20_G1.0081.00
31_L39_R1.0071.00
17_Y43_E1.0061.00
10_F14_Q0.9841.00
64_R70_R0.9571.00
151_L156_P0.9571.00
48_A118_L0.9571.00
82_A86_V0.9551.00
113_V116_L0.9541.00
88_L122_L0.9501.00
66_T69_D0.9411.00
92_L116_L0.9391.00
57_A61_L0.9391.00
135_W138_R0.9361.00
71_R74_R0.9281.00
140_A143_A0.9251.00
9_L12_A0.9251.00
52_L125_L0.9151.00
168_Y173_L0.9111.00
132_R137_A0.9091.00
70_R74_R0.8931.00
13_V17_Y0.8931.00
2_L6_L0.8831.00
48_A84_T0.8831.00
116_L120_V0.8811.00
41_F114_F0.8801.00
19_F86_V0.8761.00
106_R110_Y0.8691.00
11_V86_V0.8661.00
42_F45_V0.8631.00
159_L163_Y0.8591.00
17_Y36_Y0.8571.00
157_D181_L0.8501.00
77_A129_I0.8431.00
161_A178_L0.8371.00
68_R71_R0.8361.00
143_A147_V0.8341.00
11_V14_Q0.8331.00
159_L162_R0.8271.00
128_K136_L0.8191.00
142_V145_L0.8191.00
48_A88_L0.8181.00
104_L159_L0.8111.00
49_L53_L0.8051.00
59_F128_K0.8041.00
28_P31_L0.8021.00
132_R135_W0.8011.00
136_L139_A0.7971.00
157_D160_I0.7881.00
32_T35_E0.7841.00
181_L185_A0.7831.00
177_Y181_L0.7821.00
34_A98_Y0.7811.00
67_A70_R0.7771.00
168_Y171_G0.7771.00
79_L83_L0.7771.00
47_V84_T0.7751.00
124_L136_L0.7711.00
121_G125_L0.7711.00
124_L143_A0.7661.00
62_A73_L0.7611.00
21_G25_V0.7551.00
22_F26_L0.7531.00
103_G167_R0.7531.00
36_Y40_G0.7501.00
34_A174_D0.7441.00
145_L152_N0.7401.00
141_L145_L0.7381.00
150_A154_V0.7341.00
92_L96_R0.7331.00
88_L115_M0.7301.00
85_L88_L0.7261.00
68_R72_L0.7210.99
15_F20_G0.7190.99
131_R135_W0.7160.99
12_A16_A0.7070.99
64_R74_R0.7050.99
34_A37_A0.7040.99
52_L121_G0.7030.99
74_R129_I0.7020.99
109_L160_I0.7020.99
34_A103_G0.7000.99
63_R70_R0.6970.99
179_A183_A0.6830.99
72_L76_L0.6800.99
119_A123_V0.6800.99
99_I105_T0.6790.99
146_V149_L0.6770.99
98_Y105_T0.6750.99
75_V78_G0.6740.99
78_G82_A0.6720.99
110_Y114_F0.6710.99
175_V179_A0.6700.99
109_L154_V0.6680.99
56_L60_R0.6660.99
22_F28_P0.6650.99
36_Y94_R0.6650.99
156_P160_I0.6630.99
81_I85_L0.6620.99
174_D178_L0.6610.99
169_E172_K0.6550.99
122_L125_L0.6540.99
147_V150_A0.6520.99
112_L116_L0.6520.99
88_L92_L0.6500.99
135_W139_A0.6490.99
47_V87_L0.6460.99
6_L9_L0.6440.99
165_V168_Y0.6410.99
11_V15_F0.6400.99
66_T70_R0.6370.99
45_V114_F0.6340.99
161_A181_L0.6340.99
42_F95_M0.6320.99
13_V20_G0.6320.99
125_L136_L0.6290.99
148_L151_L0.6290.99
96_R99_I0.6230.98
53_L57_A0.6190.98
45_V49_L0.6180.98
13_V18_L0.6120.98
147_V151_L0.6110.98
59_F64_R0.6110.98
13_V33_Y0.6090.98
15_F18_L0.6060.98
143_A150_A0.6030.98
114_F117_W0.6020.98
37_A42_F0.5990.98
22_F29_A0.5920.98
32_T102_Y0.5840.98
10_F43_E0.5800.98
81_I129_I0.5750.97
176_A183_A0.5750.97
92_L115_M0.5740.97
149_L153_L0.5740.97
38_R111_V0.5720.97
46_A49_L0.5710.97
165_V178_L0.5710.97
4_N7_F0.5710.97
45_V111_V0.5690.97
165_V188_A0.5690.97
59_F77_A0.5640.97
40_G94_R0.5630.97
64_R73_L0.5600.97
18_L37_A0.5600.97
60_R63_R0.5580.97
37_A111_V0.5570.97
63_R66_T0.5570.97
95_M107_L0.5540.97
112_L115_M0.5540.97
74_R78_G0.5510.97
117_W121_G0.5500.97
110_Y156_P0.5450.97
78_G129_I0.5450.97
23_A26_L0.5440.96
172_K176_A0.5420.96
55_L125_L0.5410.96
5_L8_L0.5400.96
85_L126_L0.5400.96
10_F41_F0.5380.96
11_V19_F0.5370.96
22_F27_L0.5360.96
109_L113_V0.5360.96
106_R177_Y0.5360.96
51_A80_L0.5350.96
25_V93_L0.5280.96
86_V89_A0.5270.96
134_R138_R0.5260.96
14_Q19_F0.5250.96
58_A77_A0.5240.96
75_V127_V0.5220.96
13_V90_S0.5220.96
17_Y20_G0.5210.96
144_A151_L0.5170.95
178_L189_L0.5160.95
51_A54_L0.5140.95
81_I125_L0.5100.95
120_V124_L0.5060.95
111_V118_L0.5040.95
9_L13_V0.5020.95
142_V146_V0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xgrA 1 0.1632 3.8 0.955 Contact Map
3j9pD 4 0.7474 3.4 0.956 Contact Map
1jmuA 3 0.1368 3.3 0.956 Contact Map
2rddB 1 0.1947 1.9 0.961 Contact Map
1bzkA 1 0.2105 1.8 0.962 Contact Map
4il3A 1 0.9632 1.7 0.962 Contact Map
1rz2A 1 0.1684 1.7 0.962 Contact Map
4aw6A 2 0.9579 1.6 0.963 Contact Map
4l0nA 2 0.1 1.5 0.963 Contact Map
4o6yA 2 0.4684 1.4 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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