GREMLIN Database
DUF4169 - Domain of unknown function (DUF4169)
PFAM: PF13770 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (55)
Sequences: 7971 (5621)
Seq/√Len: 758.0
META: 0.925

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_R39_D2.8441.00
45_R49_D2.4311.00
49_D53_H1.9481.00
38_L42_E1.9401.00
19_E26_R1.8931.00
33_K37_A1.6481.00
31_R35_E1.5861.00
8_R12_A1.4031.00
24_A28_R1.2781.00
46_A49_D1.2681.00
32_T35_E1.2601.00
13_K17_E1.2491.00
14_A17_E1.2481.00
43_A47_R1.2391.00
21_Q24_A1.2341.00
17_E21_Q1.2141.00
12_A16_A1.2091.00
25_N29_F1.2001.00
20_A23_A1.1901.00
37_A40_E1.1791.00
44_E48_R1.1661.00
40_E44_E1.1511.00
9_A12_A1.1451.00
35_E39_D1.1361.00
47_R51_D1.1361.00
23_A26_R1.1311.00
39_D42_E1.1221.00
38_L41_A1.1171.00
42_E45_R1.1061.00
14_A18_K1.1051.00
43_A46_A1.0881.00
6_L10_R1.0791.00
42_E46_A1.0641.00
37_A41_A1.0641.00
18_K21_Q1.0541.00
48_R52_G1.0471.00
46_A50_L1.0341.00
22_A26_R1.0261.00
16_A19_E1.0201.00
21_Q25_N1.0021.00
2_E26_R0.9961.00
9_A13_K0.9731.00
7_R19_E0.9431.00
25_N28_R0.9361.00
13_K16_A0.9181.00
44_E47_R0.9101.00
50_L53_H0.9051.00
40_E43_A0.8821.00
41_A45_R0.8681.00
36_R40_E0.8261.00
16_A20_A0.8231.00
41_A44_E0.8171.00
17_E20_A0.8081.00
39_D43_A0.7761.00
28_R43_A0.7501.00
4_V9_A0.7471.00
23_A27_A0.7141.00
24_A27_A0.6981.00
48_R51_D0.6971.00
19_E23_A0.6921.00
12_A19_E0.6811.00
45_R48_R0.6781.00
51_D54_R0.6641.00
6_L9_A0.6521.00
20_A24_A0.6501.00
32_T36_R0.6441.00
31_R34_A0.6331.00
4_V7_R0.6301.00
28_R39_D0.6271.00
6_L13_K0.6231.00
10_R13_K0.6201.00
49_D52_G0.6081.00
50_L55_R0.5921.00
38_L45_R0.5621.00
7_R11_K0.5571.00
52_G55_R0.5421.00
5_N8_R0.5281.00
29_F36_R0.5261.00
29_F33_K0.5191.00
34_A38_L0.5181.00
35_E38_L0.5121.00
15_R19_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nysA 2 0 4.5 0.858 Contact Map
1ne3A 1 0.3455 2.3 0.879 Contact Map
3o2uA 1 0.8909 1.2 0.896 Contact Map
4rb5B 1 1 1.1 0.898 Contact Map
3bbnB 1 1 1.1 0.899 Contact Map
2nvuC 1 0.8727 1 0.901 Contact Map
4wjwA 2 0.5455 0.9 0.904 Contact Map
4ujpG 1 0.4727 0.9 0.904 Contact Map
4ftbA 7 0.4545 0.8 0.907 Contact Map
4qvrA 1 0.8 0.8 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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