GREMLIN Database
DUF4168 - Domain of unknown function (DUF4168)
PFAM: PF13767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 90 (77)
Sequences: 2888 (2145)
Seq/√Len: 244.4
META: 0.845

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_E72_E5.5591.00
80_A90_I3.4991.00
69_S72_E2.8891.00
8_F77_L2.8061.00
2_D89_R2.0241.00
14_E66_Q1.9771.00
60_V64_E1.7561.00
54_E58_E1.7141.00
63_V70_V1.6551.00
22_Y51_I1.6461.00
47_E50_R1.6041.00
53_Q57_A1.5731.00
18_I62_A1.5271.00
25_R54_E1.5001.00
14_E62_A1.4231.00
79_A86_L1.3621.00
32_D46_E1.3141.00
11_A68_L1.2831.00
49_Q53_Q1.2811.00
11_A66_Q1.2511.00
32_D47_E1.2401.00
80_A86_L1.2301.00
7_A68_L1.2221.00
9_A12_Y1.2121.00
79_A83_D1.2081.00
49_Q52_Q1.2071.00
16_E20_Q1.2041.00
72_E75_Q1.1841.00
22_Y26_L1.1671.00
10_A66_Q1.1561.00
19_R23_Q1.1531.00
33_P48_A1.0911.00
46_E49_Q1.0911.00
61_K65_D1.0571.00
26_L48_A1.0521.00
8_F76_I1.0511.00
3_Q7_A1.0241.00
18_I55_A1.0211.00
4_E76_I1.0191.00
21_E25_R1.0181.00
22_Y25_R1.0131.00
7_A67_G1.0091.00
55_A59_M1.0061.00
26_L52_Q1.0061.00
6_D9_A1.0011.00
48_A52_Q0.9811.00
70_V74_N0.9741.00
17_E20_Q0.9731.00
4_E7_A0.9681.00
84_P87_R0.9361.00
52_Q56_N0.9061.00
16_E56_N0.8901.00
85_E88_Q0.8811.00
1_S4_E0.8580.99
5_L80_A0.8560.99
16_E19_R0.8520.99
50_R54_E0.8440.99
12_Y80_A0.8380.99
11_A62_A0.8340.99
76_I86_L0.8260.99
26_L51_I0.8120.99
7_A66_Q0.8110.99
33_P46_E0.7920.99
77_L80_A0.7830.99
25_R51_I0.7500.98
22_Y58_E0.7390.98
78_Q81_Q0.7370.98
59_M63_V0.7280.98
56_N59_M0.7190.98
21_E58_E0.7150.98
71_E75_Q0.7090.98
29_A75_Q0.7080.98
31_E47_E0.6980.97
22_Y54_E0.6890.97
15_V59_M0.6880.97
30_A47_E0.6870.97
14_E17_E0.6730.97
3_Q6_D0.6730.97
18_I22_Y0.6720.97
13_L17_E0.6690.97
74_N77_L0.6670.97
30_A33_P0.6650.97
81_Q84_P0.6630.97
24_Q28_Q0.6590.96
56_N60_V0.6570.96
59_M70_V0.6410.96
30_A48_A0.6340.96
79_A82_N0.6310.95
75_Q79_A0.6250.95
18_I80_A0.6160.95
46_E57_A0.6150.95
19_R59_M0.5990.94
47_E51_I0.5990.94
29_A32_D0.5910.94
2_D6_D0.5840.93
61_K64_E0.5810.93
12_Y77_L0.5750.93
59_M62_A0.5740.93
80_A87_R0.5690.92
8_F52_Q0.5680.92
32_D48_A0.5670.92
24_Q29_A0.5620.92
19_R24_Q0.5610.92
79_A84_P0.5600.92
14_E18_I0.5560.91
9_A76_I0.5550.91
30_A58_E0.5520.91
9_A90_I0.5360.90
21_E24_Q0.5240.89
11_A15_V0.5230.89
83_D86_L0.5180.88
23_Q28_Q0.5090.87
76_I90_I0.5080.87
12_Y81_Q0.5030.87
56_N74_N0.5030.87
5_L89_R0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3viuA 1 0.3556 28 0.831 Contact Map
1zymA 2 0.9333 11.7 0.858 Contact Map
4xlgB 1 0.2667 10.3 0.861 Contact Map
4ynhA 2 0.4556 8.3 0.867 Contact Map
2wqdA 2 0.9333 7.3 0.87 Contact Map
3fh3A 2 0.9333 7.1 0.871 Contact Map
3b34A 1 0.7667 6.4 0.874 Contact Map
4qhpA 1 0.7667 6.3 0.874 Contact Map
4ka7A 1 0.9333 6.2 0.874 Contact Map
1jk0B 1 0.8556 6.1 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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