GREMLIN Database
DUF4167 - Domain of unknown function (DUF4167)
PFAM: PF13763 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (71)
Sequences: 5331 (2471)
Seq/√Len: 293.3
META: 0.959

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_N61_H2.9421.00
43_A59_L2.8671.00
66_F70_N2.4261.00
36_Y66_F2.2281.00
47_Q55_A2.1931.00
54_L58_Y2.0901.00
47_Q59_L2.0651.00
36_Y40_L1.9381.00
36_Y69_L1.9271.00
44_R48_S1.9151.00
9_R12_N1.8571.00
10_N13_R1.4941.00
5_R8_N1.4781.00
20_D27_K1.4661.00
54_L57_N1.4311.00
40_L59_L1.4191.00
4_N7_N1.3521.00
26_V29_R1.3341.00
19_F23_G1.2991.00
6_N9_R1.2531.00
66_F71_A1.2501.00
28_I35_I1.2391.00
21_S24_P1.2331.00
7_N10_N1.2081.00
6_N10_N1.1551.00
8_N12_N1.1521.00
5_R10_N1.1421.00
33_Q69_L1.1211.00
55_A59_L1.1141.00
42_L58_Y1.1001.00
46_A51_D1.0981.00
9_R13_R1.0961.00
17_R21_S1.0931.00
12_N15_R1.0891.00
32_A68_I1.0671.00
39_Y42_L1.0511.00
41_Q45_D1.0411.00
70_N73_Q1.0341.00
37_E41_Q1.0331.00
7_N11_R1.0251.00
5_R9_R1.0221.00
26_V30_G1.0081.00
45_D48_S1.0061.00
25_D28_I0.9991.00
33_Q36_Y0.9951.00
17_R22_N0.9421.00
44_R66_F0.9341.00
19_F24_P0.9241.00
68_I72_A0.9191.00
35_I40_L0.9161.00
18_S24_P0.9031.00
69_L73_Q0.8721.00
66_F69_L0.8671.00
28_I34_Q0.8651.00
51_D59_L0.8511.00
4_N11_R0.8341.00
24_P30_G0.8251.00
63_E66_F0.8071.00
18_S21_S0.7950.99
23_G28_I0.7780.99
19_F35_I0.7670.99
32_A35_I0.7650.99
20_D23_G0.7590.99
8_N11_R0.7530.99
27_K30_G0.7310.99
34_Q37_E0.7210.99
33_Q72_A0.7200.99
40_L66_F0.7090.99
23_G29_R0.7060.99
23_G26_V0.7030.99
20_D29_R0.6910.99
24_P29_R0.6860.98
54_L72_A0.6820.98
33_Q37_E0.6790.98
44_R52_R0.6770.98
37_E40_L0.6760.98
69_L72_A0.6700.98
17_R23_G0.6680.98
52_R59_L0.6570.98
32_A37_E0.6540.98
20_D24_P0.6450.98
18_S22_N0.6390.98
51_D54_L0.6370.97
48_S54_L0.6350.97
17_R20_D0.6330.97
45_D52_R0.6200.97
64_H67_R0.5990.96
44_R49_S0.5860.96
8_N13_R0.5720.95
7_N12_N0.5530.94
30_G68_I0.5530.94
22_N25_D0.5500.94
63_E67_R0.5460.94
17_R24_P0.5420.94
52_R55_A0.5420.94
25_D29_R0.5340.93
38_K46_A0.5340.93
41_Q44_R0.5330.93
3_R13_R0.5260.93
34_Q62_A0.5210.92
31_N34_Q0.5150.92
21_S29_R0.5140.92
39_Y65_Y0.5100.92
35_I38_K0.5070.91
40_L44_R0.5060.91
41_Q70_N0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uuzA 2 0.28 10.5 0.894 Contact Map
3mkqA 2 0.96 7.8 0.9 Contact Map
2jpuA 1 0.6133 7.1 0.902 Contact Map
5a1uD 1 1 4.7 0.91 Contact Map
5a1uC 1 0.9867 4.2 0.912 Contact Map
4jhrA 2 0.3333 3.5 0.915 Contact Map
2oh3A 2 0.76 3.5 0.915 Contact Map
3s6nM 1 0.2 3.2 0.916 Contact Map
2lniA 1 0.7333 2.7 0.92 Contact Map
2oo2A 2 0.6533 2.6 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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