GREMLIN Database
DUF4166 - Domain of unknown function (DUF4166)
PFAM: PF13761 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 182 (167)
Sequences: 4670 (3430)
Seq/√Len: 265.4
META: 0.858

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R53_D3.6551.00
77_T80_G3.6471.00
160_R181_W3.4161.00
166_E174_L3.0671.00
51_G54_V3.0411.00
24_D52_R3.0411.00
129_G140_P2.6411.00
8_R19_Y2.6351.00
154_R162_R2.5521.00
24_D179_R2.3931.00
119_E124_R2.3251.00
20_R57_T2.3041.00
122_G152_R2.2131.00
164_D179_R2.1691.00
174_L177_R2.1151.00
169_H172_F2.0821.00
69_G90_T2.0101.00
164_D177_R1.9861.00
57_T77_T1.8711.00
4_A7_R1.8601.00
26_E177_R1.8561.00
4_A156_D1.8311.00
34_R38_R1.7261.00
150_T166_E1.7141.00
134_W146_A1.6721.00
168_R174_L1.6561.00
65_D69_G1.6461.00
3_P7_R1.6401.00
75_T88_R1.6261.00
124_R150_T1.6211.00
3_P6_R1.6181.00
77_T86_R1.6071.00
27_R37_A1.6021.00
38_R41_R1.5731.00
24_D53_D1.5501.00
18_V57_T1.5211.00
112_A128_G1.5181.00
49_E81_R1.5121.00
166_E177_R1.4971.00
33_A37_A1.4901.00
152_R164_D1.4091.00
133_R138_G1.4021.00
112_A132_L1.3861.00
110_A133_R1.3841.00
92_R100_V1.3441.00
114_V126_R1.3401.00
124_R152_R1.2991.00
27_R174_L1.2771.00
113_L125_F1.2681.00
155_A159_G1.2531.00
73_T90_T1.2431.00
75_T86_R1.2281.00
62_T75_T1.2181.00
93_F96_G1.2131.00
122_G154_R1.2111.00
18_V60_T1.2091.00
23_A163_F1.2071.00
73_T88_R1.1821.00
148_R168_R1.1751.00
54_V78_F1.1661.00
100_V110_A1.1561.00
162_R181_W1.1391.00
32_L172_F1.1291.00
110_A135_G1.1151.00
92_R108_G1.1021.00
100_V108_G1.0951.00
28_G33_A1.0931.00
148_R153_E1.0921.00
30_G33_A1.0851.00
109_L113_L1.0631.00
22_R55_P1.0631.00
110_A129_G1.0581.00
125_F161_F1.0521.00
8_R17_V1.0481.00
87_F91_M1.0391.00
79_G84_P1.0381.00
157_E162_R1.0341.00
148_R154_R1.0181.00
62_T65_D1.0151.00
24_D51_G1.0141.00
169_H175_L1.0071.00
47_F85_R1.0051.00
111_L125_F0.9941.00
99_L125_F0.9941.00
143_R146_A0.9871.00
92_R102_R0.9791.00
58_V61_V0.9741.00
66_A90_T0.9651.00
115_V120_D0.9631.00
172_F175_L0.9621.00
108_G135_G0.9601.00
148_R170_P0.9551.00
91_M125_F0.9521.00
149_A167_V0.9311.00
114_V130_Y0.9231.00
158_D162_R0.9191.00
98_G110_A0.9171.00
151_A165_V0.9121.00
2_P121_G0.9081.00
8_R61_V0.9061.00
66_A69_G0.8991.00
25_V179_R0.8961.00
143_R148_R0.8941.00
26_E179_R0.8931.00
162_R179_R0.8901.00
58_V161_F0.8901.00
123_L153_E0.8831.00
22_R54_V0.8781.00
57_T60_T0.8711.00
51_G55_P0.8681.00
103_F107_L0.8671.00
74_W151_A0.8661.00
51_G80_G0.8651.00
108_G131_F0.8551.00
119_E126_R0.8471.00
25_V56_V0.8441.00
32_L35_L0.8430.99
27_R38_R0.8420.99
114_V119_E0.8390.99
115_V121_G0.8360.99
102_R108_G0.8290.99
47_F176_V0.8260.99
119_E122_G0.8140.99
126_R150_T0.8100.99
95_G98_G0.8090.99
156_D162_R0.8080.99
87_F103_F0.8010.99
49_E85_R0.7970.99
19_Y61_V0.7910.99
134_W141_L0.7860.99
6_R10_G0.7780.99
35_L38_R0.7760.99
40_L107_L0.7730.99
156_D181_W0.7720.99
115_V119_E0.7700.99
62_T66_A0.7690.99
5_V123_L0.7620.99
57_T78_F0.7570.99
153_E161_F0.7480.99
8_R161_F0.7460.99
27_R50_A0.7450.99
89_S101_E0.7450.99
25_V28_G0.7440.99
101_E107_L0.7380.99
11_V15_G0.7350.99
1_L5_V0.7280.99
31_L35_L0.7270.99
131_F149_A0.7160.98
23_A26_E0.7160.98
103_F161_F0.7150.98
16_A62_T0.7120.98
60_T77_T0.7070.98
41_R46_P0.7060.98
11_V18_V0.7060.98
97_R112_A0.7040.98
35_L39_L0.7020.98
22_R181_W0.7000.98
69_G73_T0.6950.98
26_E174_L0.6950.98
94_G100_V0.6930.98
90_T102_R0.6910.98
85_R89_S0.6890.98
155_A158_D0.6890.98
65_D70_E0.6850.98
91_M111_L0.6790.98
151_A155_A0.6760.98
97_R100_V0.6710.97
40_L151_A0.6700.97
149_A153_E0.6670.97
99_L115_V0.6650.97
11_V61_V0.6640.97
5_V125_F0.6600.97
11_V16_A0.6590.97
51_G79_G0.6540.97
40_L167_V0.6520.97
66_A73_T0.6510.97
65_D68_G0.6500.97
55_P58_V0.6500.97
89_S161_F0.6480.97
5_V8_R0.6470.97
148_R151_A0.6420.97
74_W147_P0.6400.97
113_L123_L0.6370.97
125_F146_A0.6370.97
61_V125_F0.6340.96
23_A87_F0.6340.96
67_G70_E0.6310.96
104_G167_V0.6310.96
93_F100_V0.6300.96
137_L140_P0.6250.96
154_R157_E0.6200.96
69_G92_R0.6190.96
28_G176_V0.6120.96
40_L87_F0.6080.96
32_L39_L0.6070.96
157_E160_R0.6050.95
25_V50_A0.6020.95
23_A54_V0.5960.95
27_R30_G0.5950.95
123_L161_F0.5950.95
10_G17_V0.5940.95
14_G18_V0.5930.95
149_A168_R0.5900.95
19_Y151_A0.5890.95
5_V17_V0.5840.94
110_A140_P0.5830.94
93_F99_L0.5770.94
25_V52_R0.5760.94
11_V17_V0.5740.94
150_T153_E0.5740.94
167_V176_V0.5730.94
5_V10_G0.5700.94
26_E52_R0.5690.94
28_G34_R0.5660.94
33_A172_F0.5630.93
150_T168_R0.5620.93
114_V128_G0.5560.93
19_Y23_A0.5550.93
4_A161_F0.5540.93
89_S163_F0.5520.93
23_A103_F0.5510.93
30_G34_R0.5490.92
121_G156_D0.5490.92
11_V14_G0.5460.92
79_G83_F0.5430.92
153_E178_Y0.5430.92
37_A176_V0.5420.92
148_R152_R0.5410.92
143_R170_P0.5410.92
128_G140_P0.5400.92
48_P85_R0.5400.92
93_F97_R0.5390.92
144_W147_P0.5390.92
17_V65_D0.5370.92
5_V154_R0.5330.91
159_G163_F0.5330.91
153_E157_E0.5330.91
94_G110_A0.5330.91
151_A154_R0.5320.91
105_P128_G0.5320.91
61_V91_M0.5290.91
120_D124_R0.5280.91
139_L144_W0.5230.91
126_R129_G0.5230.91
51_G81_R0.5120.90
149_A152_R0.5120.90
94_G98_G0.5070.89
5_V156_D0.5050.89
103_F153_E0.5010.89
100_V131_F0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l66A 2 0.1813 2.2 0.954 Contact Map
3or1C 1 0.2418 2.1 0.955 Contact Map
1ji8A 1 0.2418 2.1 0.955 Contact Map
1xcrA 1 0.5824 2 0.955 Contact Map
2mvhA 1 0.1429 2 0.955 Contact Map
1k77A 1 0.3516 1.9 0.956 Contact Map
1mvfD 1 0.1538 1.9 0.956 Contact Map
3ffvA 1 0.4835 1.8 0.956 Contact Map
1g92A 1 0.0714 1.8 0.957 Contact Map
3nqzA 1 0.4451 1.7 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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