GREMLIN Database
Stimulus_sens_1 - Stimulus-sensing domain
PFAM: PF13756 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 111 (108)
Sequences: 4496 (3073)
Seq/√Len: 295.7
META: 0.927

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_V49_L4.5051.00
79_Y90_Y3.1361.00
82_L89_D2.9631.00
6_A23_L2.6841.00
66_A70_W2.4141.00
59_L63_A2.3381.00
87_G93_V2.2791.00
76_L79_Y2.1901.00
64_Y68_R2.1691.00
16_P21_A2.0881.00
86_N89_D1.9171.00
63_A66_A1.9031.00
25_D29_R1.8781.00
14_V21_A1.8711.00
60_L63_A1.7811.00
61_E65_D1.6631.00
45_L49_L1.6201.00
25_D31_I1.5441.00
56_K60_L1.5061.00
99_G102_A1.4801.00
40_P43_D1.4681.00
92_E106_R1.4441.00
68_R71_L1.4331.00
63_A67_L1.4321.00
43_D47_F1.4001.00
10_L16_P1.3991.00
54_E57_P1.3701.00
14_V17_T1.3401.00
95_R100_E1.3341.00
52_P56_K1.3261.00
60_L64_Y1.3221.00
95_R102_A1.3011.00
42_G46_R1.2811.00
9_L12_R1.2601.00
91_P104_A1.2521.00
42_G45_L1.2211.00
41_R49_L1.2121.00
42_G47_F1.2091.00
65_D68_R1.2081.00
38_Y42_G1.1681.00
41_R45_L1.1521.00
14_V18_R1.1421.00
4_E8_P1.1421.00
12_R15_S1.1401.00
45_L48_D1.1361.00
56_K64_Y1.1171.00
13_L16_P1.1141.00
12_R35_R1.1131.00
58_G61_E1.0691.00
62_R65_D1.0621.00
62_R66_A1.0581.00
43_D46_R1.0561.00
34_S42_G1.0461.00
76_L90_Y1.0351.00
10_L21_A1.0261.00
5_R8_P1.0171.00
61_E64_Y1.0041.00
5_R9_L0.9991.00
83_G88_K0.9991.00
56_K59_L0.9761.00
41_R46_R0.9591.00
56_K65_D0.9481.00
7_A12_R0.9381.00
55_E59_L0.9281.00
82_L85_A0.9271.00
63_A73_R0.9261.00
85_A89_D0.9241.00
52_P55_E0.9211.00
99_G105_V0.9111.00
40_P46_R0.9101.00
65_D69_R0.8961.00
36_N45_L0.8851.00
3_P7_A0.8821.00
10_L14_V0.8771.00
42_G49_L0.8761.00
85_A90_Y0.8541.00
7_A32_A0.8511.00
92_E105_V0.8481.00
66_A69_R0.8291.00
59_L62_R0.8261.00
52_P57_P0.8241.00
44_V48_D0.8201.00
61_E68_R0.7991.00
44_V50_P0.7930.99
88_K94_A0.7870.99
13_L32_A0.7830.99
46_R49_L0.7820.99
10_L41_R0.7800.99
26_R36_N0.7750.99
57_P61_E0.7690.99
55_E58_G0.7610.99
16_P19_T0.7570.99
24_Y30_L0.7530.99
13_L21_A0.7450.99
17_T21_A0.7440.99
14_V19_T0.7430.99
81_E87_G0.7400.99
15_S18_R0.7300.99
21_A92_E0.7190.99
55_E61_E0.7160.99
24_Y85_A0.7160.99
20_R96_A0.7140.99
91_P95_R0.7090.99
9_L26_R0.7090.99
20_R81_E0.7020.99
9_L16_P0.6980.99
80_R88_K0.6980.99
104_A107_V0.6900.99
44_V47_F0.6900.99
57_P68_R0.6890.99
46_R50_P0.6770.98
82_L87_G0.6760.98
54_E58_G0.6650.98
24_Y90_Y0.6630.98
8_P23_L0.6620.98
7_A14_V0.6600.98
101_P104_A0.6560.98
56_K61_E0.6500.98
101_P105_V0.6490.98
64_Y70_W0.6470.98
90_Y93_V0.6400.98
56_K66_A0.6330.97
84_P87_G0.6210.97
8_P31_I0.6190.97
94_A98_A0.6190.97
65_D70_W0.6100.97
67_L70_W0.6090.97
72_G108_N0.6050.97
92_E99_G0.6010.97
91_P94_A0.6010.97
70_W75_D0.5940.96
59_L66_A0.5940.96
93_V99_G0.5890.96
79_Y87_G0.5730.95
83_G86_N0.5730.95
10_L34_S0.5660.95
20_R41_R0.5580.95
11_R42_G0.5560.95
66_A72_G0.5540.95
23_L34_S0.5530.95
3_P8_P0.5520.94
38_Y43_D0.5490.94
41_R47_F0.5480.94
81_E92_E0.5470.94
71_L76_L0.5440.94
47_F50_P0.5420.94
18_R101_P0.5410.94
45_L50_P0.5390.94
82_L88_K0.5360.94
9_L15_S0.5320.93
79_Y89_D0.5310.93
59_L69_R0.5250.93
58_G62_R0.5230.93
75_D78_L0.5150.92
7_A37_L0.5110.92
17_T24_Y0.5090.92
11_R15_S0.5070.92
2_N7_A0.5070.92
70_W76_L0.5050.91
81_E85_A0.5030.91
24_Y87_G0.5030.91
63_A69_R0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cwfA 2 0.5495 85.3 0.811 Contact Map
3pjvD 2 0.7387 8.9 0.899 Contact Map
2odaA 2 0.7387 4.6 0.912 Contact Map
3cjyA 2 0.3784 4.5 0.912 Contact Map
2v2fA 1 0.1351 4.5 0.913 Contact Map
3rqbA 2 0.3964 4.4 0.913 Contact Map
3i0uA 1 0.4865 4.3 0.914 Contact Map
1c8uA 2 0.3964 4.3 0.914 Contact Map
3zg9A 1 0.3694 4.1 0.914 Contact Map
4qd8A 3 0.3874 3.9 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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