GREMLIN Database
Sensor_TM1 - Sensor N-terminal transmembrane domain
PFAM: PF13755 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (67)
Sequences: 2869 (1429)
Seq/√Len: 174.5
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_D72_L2.8511.00
23_A27_L2.5951.00
10_S14_R2.3491.00
48_S52_Q2.1921.00
11_S15_R2.1581.00
36_Q39_A1.9881.00
19_L45_R1.9761.00
33_Y37_F1.9181.00
11_S14_R1.8871.00
65_S72_L1.8151.00
39_A43_D1.8041.00
22_L25_A1.7391.00
45_R56_I1.7341.00
4_L7_L1.5731.00
67_T70_T1.5441.00
28_V31_I1.5431.00
68_V71_D1.4411.00
5_V9_F1.3571.00
8_R35_N1.3511.00
19_L27_L1.3371.00
65_S69_D1.3341.00
9_F28_V1.3071.00
50_V54_E1.2761.00
67_T71_D1.2491.00
55_I58_G1.2011.00
42_I46_V1.1751.00
16_I20_N1.0971.00
52_Q55_I1.0811.00
32_L35_N1.0601.00
20_N27_L1.0591.00
65_S71_D1.0521.00
51_T54_E1.0491.00
31_I35_N1.0481.00
35_N46_V1.0390.99
43_D47_Q1.0380.99
46_V57_A1.0320.99
10_S32_L1.0050.99
16_I38_R0.9730.99
25_A36_Q0.9560.99
9_F13_T0.9260.99
53_A57_A0.9250.99
5_V8_R0.9250.99
16_I27_L0.8980.98
49_L53_A0.8900.98
12_L16_I0.8880.98
54_E58_G0.8870.98
46_V51_T0.8680.98
18_A33_Y0.8570.98
68_V72_L0.8560.98
62_A65_S0.8160.97
38_R45_R0.8100.97
19_L23_A0.8060.97
45_R52_Q0.8060.97
8_R18_A0.8040.97
4_L47_Q0.7920.97
19_L37_F0.7740.96
23_A47_Q0.7710.96
24_L60_I0.7610.96
11_S36_Q0.7510.95
9_F21_L0.7460.95
13_T19_L0.7380.95
57_A61_A0.7360.95
65_S70_T0.7320.95
37_F46_V0.7320.95
7_L29_A0.7250.94
29_A67_T0.7190.94
66_A70_T0.7040.94
29_A32_L0.6990.93
46_V56_I0.6770.92
58_G62_A0.6730.92
44_A56_I0.6720.92
30_G49_L0.6650.92
15_R57_A0.6560.91
65_S68_V0.6540.91
34_L72_L0.6350.90
31_I39_A0.6320.89
9_F14_R0.6100.88
47_Q71_D0.5970.87
15_R44_A0.5970.87
31_I41_L0.5930.86
44_A48_S0.5910.86
40_G44_A0.5820.85
16_I45_R0.5720.84
66_A72_L0.5710.84
52_Q57_A0.5690.84
18_A28_V0.5620.83
35_N40_G0.5600.83
4_L8_R0.5530.82
31_I62_A0.5520.82
62_A71_D0.5500.82
15_R18_A0.5400.81
32_L39_A0.5270.79
50_V57_A0.5230.78
6_S21_L0.5150.77
21_L28_V0.5140.77
42_I56_I0.5120.77
27_L53_A0.5090.77
19_L51_T0.5080.76
19_L31_I0.5020.76
15_R33_Y0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cq4A 4 0 31.6 0.845 Contact Map
3e4oA 2 0.4545 28.2 0.849 Contact Map
3cwfA 2 0.5065 21.5 0.857 Contact Map
2kseA 1 0.4805 12.9 0.871 Contact Map
2w3zA 1 0.039 9.9 0.878 Contact Map
2mj6A 1 0.5584 7.6 0.884 Contact Map
4k0jA 3 0.9221 2.8 0.905 Contact Map
3cuqA 1 0.3766 2.7 0.906 Contact Map
4akkA 2 0.6753 2.4 0.908 Contact Map
4k08A 2 0.4935 2.2 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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