GREMLIN Database
DDE_Tnp_1_6 - Transposase DDE domain
PFAM: PF13751 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (123)
Sequences: 50299 (30726)
Seq/√Len: 2770.4
META: 0.962

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_A38_L3.8541.00
6_K32_D3.6631.00
70_T73_G3.0041.00
38_L41_Q2.4561.00
95_H122_K2.3321.00
84_V87_V2.2731.00
29_R32_D2.1501.00
92_K98_R2.1301.00
58_E62_E2.0951.00
102_L107_K2.0471.00
10_Y13_T1.9981.00
100_F108_V1.9621.00
64_A67_R1.9401.00
109_R113_L1.9311.00
39_R43_T1.8991.00
93_R98_R1.8961.00
1_T7_T1.8181.00
90_T94_N1.7011.00
90_T95_H1.6991.00
104_G107_K1.6981.00
64_A68_L1.6801.00
10_Y26_A1.6551.00
90_T119_Y1.6471.00
91_L115_A1.6381.00
30_A34_R1.6011.00
97_L115_A1.5861.00
79_R82_A1.5231.00
59_E63_A1.4951.00
100_F111_E1.4941.00
101_R111_E1.4821.00
88_F92_K1.4661.00
91_L119_Y1.4491.00
68_L73_G1.3681.00
77_Y81_K1.3601.00
51_I55_P1.3511.00
112_F116_A1.3491.00
105_L109_R1.3481.00
78_R81_K1.3401.00
60_L63_A1.3221.00
79_R83_T1.3021.00
90_T122_K1.2851.00
63_A67_R1.2491.00
21_Y24_Y1.2441.00
4_A37_P1.2311.00
62_E66_A1.1831.00
82_A86_H1.1761.00
86_H89_G1.1711.00
83_T86_H1.1521.00
65_R69_D1.1491.00
73_G77_Y1.1491.00
53_R56_E1.1491.00
75_E79_R1.1451.00
87_V119_Y1.1371.00
56_E60_L1.0801.00
89_G94_N1.0661.00
86_H90_T1.0651.00
113_L116_A1.0631.00
111_E115_A1.0361.00
71_E75_E1.0131.00
93_R99_R1.0031.00
51_I54_S1.0001.00
89_G93_R0.9961.00
102_L111_E0.9771.00
33_C36_C0.9761.00
21_Y25_R0.9681.00
11_R29_R0.9641.00
107_K110_T0.9611.00
49_R52_R0.9531.00
22_K25_R0.9521.00
49_R53_R0.9481.00
63_A66_A0.9411.00
34_R39_R0.9391.00
91_L97_L0.9281.00
102_L108_V0.9211.00
100_F112_F0.9171.00
74_K77_Y0.9101.00
27_R50_T0.9101.00
58_E61_L0.9061.00
110_T114_L0.9021.00
95_H119_Y0.8981.00
66_A70_T0.8901.00
76_L79_R0.8771.00
72_E75_E0.8691.00
20_G23_R0.8691.00
43_T48_G0.8511.00
32_D35_A0.8451.00
115_A118_A0.8411.00
61_L65_R0.8391.00
66_A69_D0.8371.00
91_L112_F0.8341.00
94_N122_K0.8311.00
36_C42_C0.8311.00
71_E74_K0.8171.00
68_L77_Y0.8161.00
60_L64_A0.8131.00
19_R23_R0.8001.00
51_I56_E0.7941.00
112_F115_A0.7911.00
13_T24_Y0.7861.00
23_R26_A0.7851.00
67_R70_T0.7781.00
22_K26_A0.7781.00
108_V111_E0.7741.00
18_G21_Y0.7741.00
46_K49_R0.7691.00
74_K78_R0.7601.00
53_R58_E0.7461.00
62_E65_R0.7361.00
19_R22_K0.7341.00
87_V90_T0.7221.00
56_E59_E0.7111.00
106_E109_R0.7101.00
90_T123_R0.7101.00
72_E76_L0.7101.00
33_C42_C0.7061.00
28_Y32_D0.7051.00
89_G92_K0.7031.00
86_H123_R0.7031.00
81_K86_H0.7021.00
75_E78_R0.7011.00
95_H115_A0.6971.00
113_L117_L0.6901.00
59_E62_E0.6841.00
12_G27_R0.6711.00
91_L116_A0.6631.00
67_R76_L0.6491.00
67_R73_G0.6481.00
109_R112_F0.6421.00
48_G51_I0.6421.00
14_N17_K0.6391.00
10_Y14_N0.6361.00
119_Y123_R0.6361.00
52_R55_P0.6351.00
61_L64_A0.6351.00
20_G26_A0.6331.00
96_G99_R0.6281.00
102_L110_T0.6261.00
111_E118_A0.6221.00
114_L117_L0.6151.00
49_R55_P0.6141.00
18_G24_Y0.6021.00
110_T113_L0.6001.00
97_L112_F0.5971.00
12_G15_R0.5961.00
15_R22_K0.5961.00
3_P38_L0.5951.00
35_A39_R0.5911.00
14_N52_R0.5891.00
84_V88_F0.5811.00
25_R52_R0.5811.00
30_A47_K0.5811.00
94_N99_R0.5791.00
84_V89_G0.5761.00
77_Y82_A0.5691.00
9_T12_G0.5641.00
29_R50_T0.5611.00
9_T29_R0.5601.00
8_L28_Y0.5591.00
19_R25_R0.5571.00
99_R103_R0.5571.00
106_E110_T0.5571.00
31_S35_A0.5521.00
92_K97_L0.5501.00
78_R82_A0.5471.00
18_G22_K0.5441.00
39_R48_G0.5421.00
97_L100_F0.5381.00
27_R51_I0.5371.00
30_A48_G0.5361.00
29_R48_G0.5361.00
50_T54_S0.5341.00
88_F91_L0.5331.00
17_K22_K0.5291.00
14_N27_R0.5281.00
87_V91_L0.5171.00
45_S48_G0.5161.00
83_T87_V0.5141.00
48_G53_R0.5121.00
64_A73_G0.5091.00
20_G24_Y0.5081.00
18_G23_R0.5031.00
108_V115_A0.5021.00
119_Y122_K0.5011.00
27_R52_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.952 51.9 0.851 Contact Map
1keaA 2 0.352 14 0.889 Contact Map
1kg2A 1 0.432 8.7 0.898 Contact Map
2abkA 1 0.368 7.4 0.901 Contact Map
4uobA 1 0.392 5 0.909 Contact Map
3d06A 1 0.36 3.6 0.915 Contact Map
1ornA 1 0.376 3.6 0.915 Contact Map
4unfA 1 0.424 3.4 0.916 Contact Map
2xwcA 2 0.44 2.8 0.92 Contact Map
2qkdA 2 0.968 2 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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