GREMLIN Database
DDE_Tnp_1_5 - Transposase DDE domain
PFAM: PF13737 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 112 (109)
Sequences: 7209 (4105)
Seq/√Len: 393.2
META: 0.923

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_A59_V4.8731.00
51_P54_Q4.2291.00
74_D77_T3.7971.00
41_A78_L2.7621.00
42_L82_A2.7051.00
56_E60_R2.4811.00
2_Q5_S2.4591.00
63_L72_V2.3791.00
77_T80_R2.2231.00
45_R82_A2.1281.00
5_S64_K1.9591.00
75_Y79_S1.9331.00
32_R71_P1.8201.00
36_L39_E1.7991.00
56_E75_Y1.7651.00
39_E88_P1.7291.00
52_L79_S1.7231.00
79_S83_K1.6431.00
45_R52_L1.5871.00
52_L75_Y1.5591.00
50_L58_F1.5531.00
52_L82_A1.5121.00
101_V110_Y1.4561.00
41_A55_T1.4271.00
63_L68_L1.4131.00
94_S97_P1.3861.00
4_G54_Q1.3561.00
29_R32_R1.3551.00
17_A36_L1.3541.00
27_R30_P1.3421.00
36_L40_T1.3411.00
56_E74_D1.3131.00
5_S60_R1.3031.00
20_R31_F1.2721.00
60_R72_V1.2621.00
63_L70_L1.2611.00
5_S61_S1.2451.00
25_G30_P1.1841.00
21_A31_F1.1671.00
34_S37_A1.1571.00
59_V63_L1.1381.00
93_K96_G1.1311.00
26_K31_F1.1311.00
12_E16_A1.0871.00
79_S82_A1.0821.00
61_S64_K1.0751.00
43_T47_V1.0411.00
23_P31_F1.0341.00
73_P77_T1.0311.00
10_F63_L1.0301.00
75_Y80_R1.0271.00
55_T78_L1.0111.00
43_T48_F1.0081.00
102_V109_V1.0081.00
38_I78_L1.0011.00
21_A24_R0.9771.00
58_F61_S0.9721.00
18_W37_A0.9561.00
45_R51_P0.9451.00
20_R23_P0.9441.00
37_A40_T0.9331.00
42_L45_R0.9141.00
35_D39_E0.9051.00
22_E26_K0.9031.00
20_R71_P0.8981.00
24_R31_F0.8971.00
5_S8_V0.8901.00
37_A77_T0.8881.00
76_S80_R0.8801.00
21_A26_K0.8771.00
24_R30_P0.8751.00
7_T99_H0.8671.00
14_A18_W0.8621.00
23_P26_K0.8611.00
5_S9_W0.8481.00
76_S79_S0.8281.00
76_S81_R0.8271.00
11_D14_A0.8241.00
92_R95_D0.8221.00
90_P93_K0.8181.00
50_L54_Q0.8151.00
14_A17_A0.8141.00
33_Y80_R0.8031.00
45_R55_T0.7791.00
60_R63_L0.7781.00
13_E17_A0.7701.00
8_V43_T0.7621.00
107_L111_G0.7611.00
56_E78_L0.7601.00
15_I20_R0.7531.00
42_L78_L0.7421.00
101_V109_V0.7421.00
42_L52_L0.7351.00
26_K30_P0.7351.00
44_L58_F0.7331.00
90_P94_S0.7261.00
10_F14_A0.7221.00
9_W99_H0.7161.00
21_A30_P0.6890.99
46_A49_H0.6790.99
91_R94_S0.6790.99
31_F34_S0.6650.99
64_K67_G0.6640.99
35_D85_L0.6570.99
105_T108_K0.6570.99
64_K69_D0.6530.99
46_A52_L0.6480.99
89_L92_R0.6470.99
12_E15_I0.6430.99
14_A20_R0.6350.99
36_L102_V0.6280.99
24_R27_R0.6260.99
20_R25_G0.6240.99
83_K86_E0.6210.99
25_G31_F0.6210.99
38_I73_P0.6170.99
6_L98_L0.6140.99
93_K97_P0.6060.99
17_A20_R0.6030.99
2_Q7_T0.6030.99
15_I36_L0.5990.99
51_P55_T0.5970.99
25_G29_R0.5950.99
98_L102_V0.5930.98
92_R97_P0.5870.98
99_H109_V0.5860.98
13_E18_W0.5860.98
59_V72_V0.5830.98
26_K29_R0.5740.98
46_A82_A0.5720.98
40_T75_Y0.5700.98
21_A25_G0.5660.98
69_D94_S0.5650.98
9_W12_E0.5640.98
43_T46_A0.5630.98
46_A51_P0.5600.98
56_E72_V0.5550.98
96_G99_H0.5550.98
8_V100_L0.5510.98
65_L68_L0.5450.97
62_L65_L0.5450.97
10_F44_L0.5450.97
60_R71_P0.5420.97
35_D81_R0.5400.97
16_A20_R0.5380.97
100_L110_Y0.5370.97
55_T58_F0.5350.97
33_Y71_P0.5330.97
20_R24_R0.5310.97
9_W44_L0.5280.97
91_R95_D0.5270.97
99_H102_V0.5250.97
61_S65_L0.5230.97
33_Y72_V0.5210.97
39_E85_L0.5140.96
47_V50_L0.5100.96
11_D104_S0.5090.96
53_R56_E0.5090.96
39_E46_A0.5090.96
9_W47_V0.5070.96
84_T89_L0.5070.96
22_E31_F0.5060.96
2_Q22_E0.5050.96
103_D106_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cobA 1 0.6161 18.5 0.914 Contact Map
4u7bA 2 0.875 13 0.92 Contact Map
4fcyA 4 0.9196 10.1 0.924 Contact Map
4n78F 1 0 8.6 0.926 Contact Map
1pdnC 1 0.6964 6.4 0.93 Contact Map
4ftbD 1 0.1875 5.8 0.932 Contact Map
2rqrA 1 0.375 5.7 0.932 Contact Map
1novD 1 0.1786 5.4 0.933 Contact Map
1f8vD 3 0.2321 4.9 0.934 Contact Map
2jmlA 1 0.5893 4.8 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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