GREMLIN Database
WxL - WxL domain surface cell wall-binding
PFAM: PF13731 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 212 (203)
Sequences: 1247 (1087)
Seq/√Len: 76.3
META: 0.211

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_V204_L7.1631.00
46_D91_T4.2181.00
15_T55_T3.2961.00
106_Q202_T3.2881.00
126_N184_S3.2121.00
109_F202_T2.9981.00
51_F124_L2.9441.00
88_V102_L2.8991.00
103_T155_A2.8981.00
46_D89_Q2.7591.00
107_S202_T2.6281.00
159_M172_Y2.5721.00
108_Q116_E2.4761.00
125_K186_T2.3881.00
121_E188_T2.3181.00
51_F185_V2.2951.00
17_G93_N2.2911.00
62_D188_T2.2301.00
145_V149_L2.1661.00
99_G166_G2.1041.00
13_T55_T2.0821.00
102_L208_L2.0771.00
107_S205_T2.0391.00
94_R210_D2.0131.00
15_T57_K1.9961.00
64_T188_T1.9741.00
103_T209_S1.9481.00
11_T52_D1.9401.00
56_Q65_Y1.9371.00
107_S203_T1.9161.00
97_N167_A1.9111.00
45_I102_L1.8831.00
65_Y189_V1.8701.00
43_L94_R1.8021.00
129_V159_M1.8021.00
59_S63_Q1.8011.00
191_G195_K1.7681.00
47_Y70_Q1.7541.00
64_T186_T1.6871.00
66_Y186_T1.6831.00
124_L185_V1.6661.00
102_L159_M1.6211.00
99_G161_A1.6031.00
130_V173_R1.5991.00
105_K155_A1.5740.99
162_A165_Q1.5450.99
44_S91_T1.5080.99
161_A166_G1.5050.99
87_Y171_V1.4950.99
46_D169_T1.4800.99
62_D191_G1.4580.99
113_G198_G1.4510.99
95_G166_G1.3900.99
47_Y87_Y1.3900.99
124_L145_V1.3890.99
166_G170_W1.3800.99
90_V100_W1.3650.98
7_T107_S1.3480.98
111_T198_G1.3230.98
66_Y183_D1.2650.97
149_L152_G1.2590.97
52_D68_K1.2430.97
137_A140_P1.2370.97
18_T57_K1.2240.97
122_L204_L1.2200.97
7_T203_T1.2100.97
53_F117_L1.2080.97
127_G174_F1.2070.97
128_T173_R1.2040.97
98_A210_D1.1910.96
157_T160_T1.1760.96
177_D180_A1.1640.96
60_S194_A1.1540.96
17_G57_K1.1440.95
65_Y191_G1.1400.95
21_T28_D1.1310.95
101_T160_T1.1150.95
118_T193_T1.1000.94
41_G89_Q1.0610.93
175_G184_S1.0450.93
131_S170_W1.0450.93
119_G190_P1.0400.92
132_N135_N1.0330.92
91_T169_T1.0240.92
122_L187_L1.0220.92
117_L189_V1.0050.91
51_F208_L0.9920.90
24_V171_V0.9860.90
88_V159_M0.9820.90
69_A182_N0.9680.89
155_A209_S0.9670.89
100_W170_W0.9640.89
95_G98_A0.9580.89
20_P23_P0.9560.89
106_Q151_P0.9500.88
37_P44_S0.9420.88
197_A200_Y0.9400.88
49_S70_Q0.9390.88
105_K205_T0.9380.88
94_R99_G0.9350.88
86_N184_S0.9330.87
142_A145_V0.9330.87
45_I49_S0.9300.87
123_T186_T0.9240.87
130_V171_V0.9190.87
4_T7_T0.9070.86
144_T147_L0.9010.86
26_P29_P0.8910.85
57_K63_Q0.8800.84
25_D84_R0.8780.84
10_G109_F0.8720.84
104_V202_T0.8660.83
170_W173_R0.8580.83
123_T188_T0.8490.82
161_A164_G0.8390.81
7_T13_T0.8380.81
35_P50_S0.8270.80
78_D81_T0.8240.80
17_G20_P0.8230.80
103_T157_T0.8230.80
95_G200_Y0.8180.80
120_A190_P0.8130.79
101_T157_T0.8130.79
127_G172_Y0.8110.79
45_I208_L0.8020.78
84_R170_W0.8010.78
95_G161_A0.7960.78
95_G99_G0.7940.78
25_D29_P0.7930.77
121_E146_T0.7880.77
6_A48_V0.7870.77
6_A45_I0.7860.77
7_T10_G0.7860.77
47_Y106_Q0.7760.76
78_D82_K0.7690.75
176_D180_A0.7680.75
43_L91_T0.7670.75
25_D35_P0.7640.75
40_T44_S0.7590.74
105_K152_G0.7560.74
110_K113_G0.7540.74
47_Y89_Q0.7540.74
108_Q152_G0.7540.74
35_P38_G0.7540.74
51_F106_Q0.7510.74
58_I62_D0.7490.73
52_D122_L0.7490.73
19_D22_D0.7470.73
131_S137_A0.7440.73
70_Q87_Y0.7440.73
89_Q169_T0.7410.73
9_N201_T0.7410.73
150_D153_G0.7410.73
170_W194_A0.7400.72
115_K196_A0.7360.72
25_D28_D0.7350.72
76_G79_G0.7340.72
44_S89_Q0.7340.72
97_N201_T0.7330.72
83_E182_N0.7320.72
8_S49_S0.7320.72
97_N196_A0.7320.72
120_A193_T0.7310.72
152_G156_Q0.7300.71
24_V28_D0.7300.71
185_V190_P0.7230.71
106_Q204_L0.7220.71
100_W208_L0.7190.70
151_P154_A0.7180.70
99_G168_G0.7160.70
100_W124_L0.7100.69
18_T178_E0.7060.69
206_W212_P0.7050.69
65_Y185_V0.7040.69
76_G81_T0.7030.69
44_S93_N0.7030.69
177_D181_T0.7010.68
157_T209_S0.7000.68
58_I65_Y0.6960.68
86_N126_N0.6960.68
34_P153_G0.6960.68
93_N195_K0.6960.68
6_A39_T0.6930.67
168_G190_P0.6930.67
27_T85_P0.6920.67
167_A198_G0.6900.67
77_T80_G0.6860.67
109_F172_Y0.6850.67
39_T195_K0.6730.65
145_V157_T0.6720.65
108_Q120_A0.6680.65
23_P29_P0.6680.65
98_A164_G0.6660.64
14_F201_T0.6630.64
109_F203_T0.6610.64
60_S134_G0.6590.64
131_S166_G0.6570.63
37_P89_Q0.6570.63
10_G202_T0.6540.63
95_G167_A0.6530.63
32_T35_P0.6510.63
13_T199_T0.6510.63
194_A197_A0.6490.62
193_T198_G0.6480.62
9_N203_T0.6460.62
16_P42_P0.6430.62
19_D185_V0.6420.62
125_K184_S0.6380.61
59_S191_G0.6380.61
22_D26_P0.6370.61
53_F206_W0.6310.60
20_P31_P0.6290.60
11_T15_T0.6280.60
77_T81_T0.6260.60
46_D117_L0.6230.59
86_N185_V0.6200.59
166_G200_Y0.6170.59
67_A70_Q0.6160.58
45_I48_V0.6150.58
105_K154_A0.6090.58
38_G50_S0.6090.58
41_G46_D0.6060.57
118_T155_A0.6040.57
52_D55_T0.6010.57
180_A183_D0.5970.56
150_D154_A0.5940.56
43_L46_D0.5930.56
7_T62_D0.5890.55
45_I88_V0.5860.55
164_G167_A0.5850.55
147_L150_D0.5840.54
133_S139_P0.5830.54
42_P95_G0.5820.54
115_K118_T0.5800.54
58_I195_K0.5760.53
77_T84_R0.5740.53
76_G82_K0.5720.53
84_R182_N0.5720.53
23_P38_G0.5710.53
100_W161_A0.5710.53
64_T110_K0.5700.53
95_G168_G0.5690.53
17_G95_G0.5660.52
49_S102_L0.5660.52
24_V29_P0.5650.52
86_N109_F0.5640.52
57_K132_N0.5630.52
90_V178_E0.5620.52
105_K207_T0.5620.52
133_S138_P0.5610.52
21_T32_T0.5610.52
93_N200_Y0.5610.52
149_L189_V0.5600.51
191_G194_A0.5550.51
189_V195_K0.5540.51
146_T149_L0.5530.51
87_Y172_Y0.5530.51
13_T201_T0.5530.51
123_T144_T0.5520.50
106_Q205_T0.5520.50
29_P34_P0.5510.50
19_D113_G0.5500.50
90_V208_L0.5490.50
42_P191_G0.5470.50
121_E186_T0.5450.50
174_F184_S0.5450.50
8_S63_Q0.5440.49
15_T19_D0.5440.49
30_D36_P0.5430.49
33_D192_G0.5400.49
4_T210_D0.5380.49
174_F206_W0.5350.48
142_A146_T0.5340.48
69_A127_G0.5320.48
195_K200_Y0.5320.48
12_V182_N0.5310.48
196_A202_T0.5300.48
60_S97_N0.5300.48
10_G116_E0.5300.48
13_T18_T0.5290.47
99_G119_G0.5280.47
25_D34_P0.5280.47
109_F122_L0.5280.47
18_T21_T0.5250.47
143_S146_T0.5240.47
42_P93_N0.5240.47
25_D32_T0.5240.47
150_D205_T0.5230.47
22_D30_D0.5230.47
20_P27_T0.5210.46
4_T11_T0.5190.46
7_T113_G0.5160.46
13_T211_T0.5120.45
20_P37_P0.5110.45
77_T82_K0.5100.45
207_T210_D0.5080.45
161_A170_W0.5050.44
9_N50_S0.5050.44
145_V154_A0.5030.44
102_L197_A0.5020.44
119_G166_G0.5020.44
12_V22_D0.5020.44
33_D36_P0.5000.44
159_M170_W0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f85A 1 0.9009 3.2 0.947 Contact Map
2ns0A 1 0.1792 2.9 0.948 Contact Map
3f83A 1 0.8679 2.4 0.95 Contact Map
3onrA 5 0.3066 1.5 0.955 Contact Map
3e21A 1 0.1509 1.5 0.955 Contact Map
4lmxA 2 0.2406 1.4 0.956 Contact Map
1j83A 1 0.5943 1.4 0.956 Contact Map
2cc6A 5 0.2783 1.3 0.957 Contact Map
4jrfA 3 0.2642 1.3 0.957 Contact Map
3emfA 3 0.4953 1.3 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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