GREMLIN Database
CstA_5TM - 5TM C-terminal transporter carbon starvation CstA
PFAM: PF13722 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 115 (113)
Sequences: 15573 (7108)
Seq/√Len: 668.7
META: 0.893

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_T101_T5.2241.00
98_A102_L3.7691.00
92_I98_A2.4831.00
102_L106_V2.4611.00
85_L105_A2.3021.00
99_W103_I2.2191.00
111_V114_T2.2091.00
49_T52_A2.1471.00
40_K43_R2.0981.00
41_P44_N1.9681.00
27_G52_A1.7991.00
107_F111_V1.7591.00
88_T102_L1.7251.00
47_P50_L1.7191.00
90_Y94_M1.6971.00
97_Y100_V1.6701.00
48_A52_A1.5871.00
4_W8_A1.5521.00
49_T53_V1.5481.00
31_L35_L1.4981.00
81_A109_L1.4691.00
53_V56_A1.4661.00
6_H9_I1.4581.00
81_A112_T1.4471.00
57_V61_F1.4401.00
109_L113_L1.4111.00
60_A63_G1.4091.00
56_A59_L1.3891.00
81_A85_L1.3811.00
88_T98_A1.3741.00
54_A58_A1.3591.00
48_A51_I1.3571.00
91_L101_T1.3531.00
52_A56_A1.3331.00
98_A101_T1.3151.00
106_V110_V1.2631.00
83_A87_A1.2541.00
67_T70_P1.2451.00
74_I78_L1.2151.00
27_G56_A1.2061.00
56_A60_A1.1981.00
24_T56_A1.1921.00
13_A17_L1.1821.00
53_V57_V1.1781.00
40_K44_N1.1671.00
103_I106_V1.1621.00
87_A101_T1.1601.00
38_V41_P1.1511.00
58_A61_F1.1261.00
8_A11_F1.1241.00
89_V92_I1.1111.00
85_L109_L1.1111.00
110_V114_T1.0741.00
47_P51_I1.0731.00
88_T92_I1.0471.00
8_A16_I1.0461.00
50_L54_A1.0401.00
44_N47_P1.0291.00
92_I95_G1.0191.00
20_L23_G1.0121.00
30_I34_L1.0111.00
36_G39_Q0.9931.00
63_G66_N0.9891.00
80_A108_M0.9831.00
47_P52_A0.9781.00
55_L59_L0.9741.00
5_Y8_A0.9631.00
46_W50_L0.9561.00
99_W102_L0.9391.00
93_K96_K0.9381.00
18_T22_T0.9181.00
54_A57_V0.8961.00
52_A55_L0.8911.00
12_E16_I0.8661.00
4_W7_F0.8651.00
105_A108_M0.8581.00
35_L39_Q0.8501.00
108_M111_V0.8491.00
43_R47_P0.8471.00
65_I70_P0.8461.00
50_L53_V0.8421.00
49_T57_V0.8311.00
48_A53_V0.8301.00
18_T21_D0.8261.00
81_A84_L0.8241.00
11_F14_L0.8231.00
74_I108_M0.8201.00
78_L112_T0.8191.00
31_L52_A0.8181.00
5_Y9_I0.8131.00
105_A109_L0.8071.00
58_A62_W0.7981.00
50_L55_L0.7941.00
19_T72_F0.7911.00
32_Q48_A0.7861.00
81_A90_Y0.7731.00
91_L98_A0.7641.00
19_T26_V0.7511.00
43_R46_W0.7471.00
89_V93_K0.7341.00
53_V59_L0.7311.00
35_L38_V0.7271.00
51_I55_L0.7251.00
49_T56_A0.7221.00
51_I54_A0.7201.00
3_F6_H0.7181.00
11_F15_F0.7171.00
37_I47_P0.7171.00
27_G30_I0.7141.00
82_L93_K0.7051.00
26_V29_F0.7021.00
91_L94_M0.7021.00
42_L46_W0.7011.00
78_L81_A0.6931.00
90_Y93_K0.6921.00
6_H11_F0.6911.00
87_A91_L0.6891.00
36_G43_R0.6871.00
31_L48_A0.6831.00
8_A12_E0.6801.00
87_A90_Y0.6781.00
10_M17_L0.6761.00
66_N70_P0.6761.00
10_M14_L0.6761.00
34_L38_V0.6751.00
84_L105_A0.6751.00
48_A54_A0.6631.00
55_L58_A0.6611.00
91_L96_K0.6551.00
94_M98_A0.6501.00
42_L47_P0.6251.00
73_G77_Q0.6251.00
37_I43_R0.6231.00
107_F110_V0.6101.00
19_T24_T0.6071.00
51_I56_A0.6031.00
102_L105_A0.5981.00
6_H10_M0.5851.00
92_I102_L0.5801.00
108_M112_T0.5771.00
71_L74_I0.5681.00
41_P45_R0.5641.00
86_V90_Y0.5641.00
84_L87_A0.5621.00
66_N74_I0.5611.00
34_L79_L0.5601.00
85_L89_V0.5601.00
19_T22_T0.5581.00
63_G67_T0.5561.00
29_F32_Q0.5541.00
20_L24_T0.5511.00
57_V60_A0.5431.00
65_I68_L0.5401.00
15_F29_F0.5391.00
24_T53_V0.5381.00
83_A86_V0.5371.00
69_W108_M0.5250.99
103_I107_F0.5160.99
98_A105_A0.5150.99
47_P54_A0.5130.99
10_M13_A0.5130.99
37_I44_N0.5130.99
6_H12_E0.5100.99
3_F19_T0.5080.99
13_A16_I0.5080.99
73_G81_A0.5030.99
62_W66_N0.5030.99
14_L17_L0.5020.99
48_A55_L0.5010.99
9_I12_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wswA 3 0.7652 57.3 0.877 Contact Map
4c7rA 3 0.7826 38.2 0.89 Contact Map
4xp4A 1 1 11.4 0.914 Contact Map
3giaA 1 0.9565 9.8 0.917 Contact Map
2a65A 2 0.9826 5.9 0.925 Contact Map
4wgvA 2 0.9739 4.8 0.928 Contact Map
3m73A 3 0.9478 3.7 0.931 Contact Map
4p02A 1 0.5913 2.3 0.939 Contact Map
3dh4A 3 0.9739 2.2 0.939 Contact Map
3hb3B 1 0.7913 2.2 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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