GREMLIN Database
DUF4160 - Domain of unknown function (DUF4160)
PFAM: PF13711 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 65 (64)
Sequences: 38708 (25684)
Seq/√Len: 3210.5
META: 0.971

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_F46_L2.4771.00
18_F53_A2.3361.00
5_F21_E2.1451.00
57_R61_L2.0651.00
30_W33_P1.9811.00
28_K37_A1.9481.00
56_H59_E1.9091.00
30_W37_A1.8981.00
34_V53_A1.7311.00
9_N12_D1.7281.00
59_E63_A1.6111.00
32_E61_L1.6021.00
16_P61_L1.5881.00
28_K38_E1.5831.00
42_P45_E1.5081.00
29_F36_L1.5061.00
21_E26_E1.4841.00
36_L46_L1.4481.00
22_Y25_Y1.4371.00
30_W35_E1.3561.00
46_L50_L1.3461.00
29_F50_L1.2941.00
2_I20_V1.2181.00
27_A41_L1.1971.00
25_Y42_P1.1851.00
12_D15_P1.1821.00
22_Y45_E1.1791.00
50_L53_A1.1431.00
58_D62_E1.1291.00
16_P60_L1.0981.00
15_P30_W1.0941.00
41_L49_V1.0201.00
53_A60_L1.0131.00
27_A36_L1.0051.00
43_R47_R0.9801.00
48_L51_E0.9621.00
27_A46_L0.9521.00
53_A57_R0.9501.00
19_H28_K0.9431.00
62_E65_N0.9401.00
41_L45_E0.8981.00
14_E28_K0.8931.00
32_E57_R0.8621.00
52_W56_H0.8481.00
50_L54_E0.8471.00
45_E48_L0.8381.00
61_L65_N0.8301.00
31_I60_L0.8211.00
36_L39_G0.8181.00
34_V50_L0.8111.00
25_Y41_L0.8091.00
5_F8_S0.7991.00
34_V57_R0.7891.00
20_V49_V0.7891.00
20_V29_F0.7891.00
52_W55_E0.7851.00
5_F26_E0.7621.00
21_E24_G0.7611.00
4_I60_L0.7321.00
7_Y10_D0.7321.00
39_G46_L0.7301.00
58_D61_L0.7291.00
25_Y40_G0.7271.00
47_R50_L0.7261.00
44_R48_L0.7171.00
4_I52_W0.7151.00
2_I22_Y0.7051.00
4_I18_F0.7041.00
1_G22_Y0.6901.00
59_E62_E0.6901.00
3_R21_E0.6841.00
2_I49_V0.6741.00
51_E55_E0.6571.00
26_E38_E0.6561.00
29_F53_A0.6541.00
2_I45_E0.6511.00
48_L52_W0.6471.00
54_E57_R0.6431.00
51_E54_E0.6371.00
2_I41_L0.6371.00
47_R51_E0.6291.00
45_E51_E0.6091.00
16_P65_N0.6071.00
30_W34_V0.6031.00
31_I61_L0.5911.00
55_E59_E0.5841.00
15_P32_E0.5801.00
52_W60_L0.5541.00
8_S12_D0.5471.00
44_R47_R0.5381.00
9_N13_H0.5381.00
15_P35_E0.5231.00
33_P57_R0.5221.00
4_I49_V0.5161.00
3_R7_Y0.5031.00
20_V41_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4akgA 2 0.8615 10.9 0.845 Contact Map
3pmcA 2 0.3077 10.3 0.847 Contact Map
3pmdA 2 0.4154 10.2 0.847 Contact Map
3dljA 2 0.3846 9.6 0.849 Contact Map
2bnlA 2 0.3231 9.5 0.849 Contact Map
3vkgA 2 0.8615 9 0.851 Contact Map
2l4hA 1 0.3846 9 0.851 Contact Map
4rh7A 1 0.8615 8.4 0.853 Contact Map
2kglA 1 0.5077 6.3 0.861 Contact Map
4bj6A 1 1 5.5 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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