GREMLIN Database
DUF4942 - Domain of unknown function (DUF4942)
PFAM: PF13708 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 199 (192)
Sequences: 1949 (1623)
Seq/√Len: 117.1
META: 0.819

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_R180_E4.8591.00
163_E182_K4.8311.00
28_E32_K3.4471.00
129_D166_Y2.9501.00
92_K180_E2.7641.00
26_A64_E2.3401.00
163_E168_R2.2401.00
94_I179_L2.2291.00
43_T46_N2.1661.00
12_L42_F2.1361.00
6_R35_E2.1281.00
29_E33_Q2.1101.00
144_L148_I2.0921.00
72_K117_K2.0691.00
52_E56_A2.0421.00
8_Y42_F2.0221.00
5_K41_E1.9701.00
92_K184_P1.9561.00
11_A15_K1.9461.00
94_I181_F1.9341.00
57_N60_E1.8871.00
97_P174_K1.8671.00
184_P188_D1.8101.00
25_K68_E1.7861.00
53_Q57_N1.7711.00
44_E48_Y1.7321.00
145_L148_I1.7041.00
25_K28_E1.6941.00
162_I169_V1.6831.00
32_K36_E1.6821.00
168_R182_K1.6641.00
93_R170_R1.6561.00
24_S116_D1.6141.00
129_D183_R1.5951.00
185_D188_D1.5791.00
183_R186_L1.5711.00
141_T145_L1.5541.00
157_G160_K1.5291.00
169_V177_A1.5251.00
131_K165_E1.5241.00
194_V198_Y1.5201.00
23_T26_A1.4771.00
193_I196_R1.4761.00
10_R14_D1.4671.00
144_L147_A1.4661.00
189_K193_I1.4581.00
62_F127_Y1.4561.00
137_R140_I1.4451.00
141_T144_L1.4411.00
19_T31_N1.4111.00
113_S116_D1.3951.00
23_T68_E1.3831.00
25_K29_E1.3761.00
67_L198_Y1.3761.00
24_S28_E1.3731.00
22_M30_W1.3591.00
63_E193_I1.3401.00
17_G20_K1.3401.00
187_L190_L1.3391.00
142_S146_D1.3371.00
114_A117_K1.3251.00
169_V179_L1.3221.00
90_I190_L1.3181.00
102_Y106_G1.3161.00
99_L177_A1.3021.00
143_R146_D1.3011.00
84_T93_R1.2991.00
125_F186_L1.2971.00
184_P187_L1.2670.99
73_L94_I1.2650.99
140_I144_L1.2610.99
181_F187_L1.2530.99
102_Y105_W1.2300.99
76_R79_Y1.2220.99
84_T95_I1.2200.99
100_V103_G1.2120.99
189_K192_R1.2030.99
66_V193_I1.1960.99
71_D198_Y1.1950.99
192_R196_R1.1940.99
32_K35_E1.1940.99
126_A166_Y1.1710.99
26_A29_E1.1660.99
12_L47_I1.1590.99
100_V106_G1.1320.99
101_S106_G1.1240.99
116_D119_D1.1180.99
171_F177_A1.1060.99
84_T180_E1.1020.98
66_V190_L1.1010.98
97_P176_T1.0990.98
90_I194_V1.0820.98
80_E174_K1.0810.98
122_E164_T1.0790.98
89_K188_D1.0490.98
161_W168_R1.0430.98
49_A53_Q1.0370.98
16_T51_L1.0330.98
188_D192_R1.0260.98
48_Y52_E1.0250.98
136_H140_I1.0220.98
74_S81_G1.0200.97
28_E31_N1.0120.97
144_L149_R1.0060.97
128_L189_K0.9820.97
70_F194_V0.9810.97
60_E64_E0.9750.97
10_R31_N0.9680.97
161_W180_E0.9600.96
137_R141_T0.9320.96
23_T64_E0.9260.96
125_F187_L0.9230.95
194_V197_H0.9120.95
71_D85_N0.8980.95
100_V104_W0.8970.95
40_P50_T0.8960.95
18_I22_M0.8890.94
54_L58_R0.8840.94
91_G187_L0.8830.94
71_D74_S0.8820.94
49_A52_E0.8820.94
43_T177_A0.8790.94
63_E197_H0.8790.94
63_E196_R0.8760.94
19_T27_R0.8740.94
24_S120_D0.8690.94
73_L179_L0.8640.94
146_D149_R0.8550.93
131_K166_Y0.8400.93
16_T54_L0.8360.92
122_E167_F0.8350.92
14_D19_T0.8320.92
111_S114_A0.8240.92
93_R180_E0.8210.92
161_W170_R0.8200.92
58_R61_I0.8150.91
140_I145_L0.8100.91
129_D186_L0.8080.91
74_S87_P0.8070.91
101_S109_S0.8070.91
140_I143_R0.8050.91
22_M54_L0.7970.91
190_L194_V0.7950.90
12_L15_K0.7900.90
67_L197_H0.7900.90
44_E47_I0.7860.90
65_G123_K0.7830.90
22_M26_A0.7780.89
96_L177_A0.7610.88
55_I58_R0.7610.88
46_N49_A0.7610.88
133_I136_H0.7600.88
63_E67_L0.7590.88
27_R116_D0.7590.88
101_S104_W0.7580.88
139_G142_S0.7570.88
96_L99_L0.7560.88
103_G106_G0.7540.88
158_E161_W0.7520.88
90_I187_L0.7470.87
75_N82_Y0.7420.87
141_T146_D0.7390.87
135_D138_N0.7350.87
69_V124_V0.7350.87
142_S145_L0.7330.86
73_L195_A0.7260.86
26_A61_I0.7210.86
60_E63_E0.7210.86
70_F90_I0.7210.86
72_K120_D0.7200.85
134_P138_N0.7140.85
143_R148_I0.7110.85
167_F179_L0.7100.85
5_K8_Y0.7080.85
185_D189_K0.7050.84
129_D165_E0.7040.84
6_R15_K0.7040.84
98_G114_A0.7020.84
4_L8_Y0.7000.84
137_R142_S0.6970.84
6_R34_L0.6970.84
74_S82_Y0.6960.84
54_L61_I0.6910.83
95_I178_H0.6880.83
27_R31_N0.6860.83
101_S105_W0.6850.83
73_L77_H0.6820.82
57_N61_I0.6820.82
132_P136_H0.6820.82
129_D189_K0.6780.82
193_I197_H0.6770.82
149_R155_E0.6770.82
166_Y186_L0.6750.82
87_P195_A0.6660.81
22_M61_I0.6610.80
71_D172_Y0.6580.80
170_R180_E0.6540.80
34_L40_P0.6530.79
70_F73_L0.6510.79
77_H80_E0.6480.79
73_L90_I0.6480.79
4_L126_A0.6420.78
52_E55_I0.6380.78
58_R62_F0.6380.78
159_G170_R0.6340.77
61_I123_K0.6330.77
118_L122_E0.6220.76
136_H139_G0.6210.76
29_E64_E0.6210.76
86_S89_K0.6210.76
80_E84_T0.6190.76
114_A143_R0.6160.75
136_H141_T0.6130.75
85_N178_H0.6130.75
105_W113_S0.6120.75
47_I68_E0.6110.75
139_G144_L0.6100.75
68_E72_K0.6080.74
122_E165_E0.6030.74
77_H87_P0.6010.74
33_Q41_E0.6010.74
88_Y96_L0.5970.73
132_P135_D0.5960.73
107_F111_S0.5960.73
65_G124_V0.5940.73
125_F167_F0.5930.73
41_E44_E0.5930.73
157_G161_W0.5930.73
3_E7_K0.5890.72
36_E39_T0.5870.72
81_G87_P0.5870.72
138_N141_T0.5850.72
18_I26_A0.5840.72
135_D141_T0.5830.71
98_G113_S0.5830.71
134_P137_R0.5830.71
142_S147_A0.5800.71
13_F26_A0.5800.71
143_R147_A0.5790.71
67_L194_V0.5790.71
119_D122_E0.5780.71
41_E46_N0.5770.71
100_V105_W0.5760.70
148_I171_F0.5760.70
160_K171_F0.5730.70
75_N81_G0.5700.70
53_Q56_A0.5690.70
6_R38_D0.5680.69
64_E68_E0.5680.69
15_K20_K0.5670.69
81_G97_P0.5670.69
74_S79_Y0.5640.69
55_I59_G0.5630.69
36_E52_E0.5610.68
33_Q36_E0.5590.68
25_K64_E0.5560.68
69_V121_L0.5520.67
82_Y97_P0.5470.67
124_V128_L0.5460.66
10_R35_E0.5430.66
34_L37_Q0.5410.66
66_V124_V0.5390.65
64_E197_H0.5390.65
82_Y190_L0.5360.65
27_R119_D0.5350.65
69_V73_L0.5330.65
75_N78_Y0.5330.65
111_S146_D0.5300.64
15_K18_I0.5290.64
73_L96_L0.5280.64
109_S112_Y0.5280.64
18_I51_L0.5250.63
139_G145_L0.5250.63
99_L115_R0.5250.63
59_G63_E0.5220.63
183_R187_L0.5180.62
66_V194_V0.5160.62
8_Y18_I0.5150.62
112_Y117_K0.5140.62
82_Y176_T0.5140.62
125_F181_F0.5120.61
94_I159_G0.5110.61
103_G144_L0.5090.61
13_F34_L0.5060.61
125_F128_L0.5060.61
34_L54_L0.5010.60
40_P78_Y0.5010.60
66_V76_R0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qneA 2 0.3166 16.4 0.942 Contact Map
4yycA 2 0.2764 11.7 0.946 Contact Map
1n4cA 1 0.3769 8.8 0.949 Contact Map
4yiiA 1 0.3367 8.4 0.949 Contact Map
1z5hA 3 0.3417 6.7 0.951 Contact Map
1mg4A 1 0.1809 5.3 0.954 Contact Map
4ie5A 1 0.2915 5.2 0.954 Contact Map
4kx7A 1 0.3819 4.9 0.954 Contact Map
2x6hA 2 0.3719 4.7 0.955 Contact Map
2k6lA 2 0.1357 4.5 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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