GREMLIN Database
RloB - RloB-like protein
PFAM: PF13707 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 193 (185)
Sequences: 6660 (5747)
Seq/√Len: 422.5
META: 0.875

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_K191_E4.5141.00
171_D187_Y3.8691.00
115_D166_N3.3361.00
65_E192_E3.1421.00
115_D169_K2.9921.00
67_W99_A2.9911.00
105_F109_L2.9621.00
7_G11_E2.7031.00
114_E128_K2.5811.00
162_T166_N2.4631.00
12_P16_E2.4421.00
15_F186_V2.2801.00
107_L170_L2.2151.00
107_L111_L2.1661.00
114_E132_H2.0961.00
15_F69_V2.0611.00
43_S46_S2.0181.00
171_D185_T1.9721.00
111_L170_L1.9351.00
185_T188_K1.8961.00
162_T165_K1.8941.00
171_D188_K1.8811.00
7_G10_T1.8581.00
65_E97_K1.8111.00
164_I191_E1.7931.00
52_I95_N1.7751.00
1_I192_E1.7411.00
2_L63_Y1.6721.00
50_R53_E1.6661.00
3_I15_F1.6601.00
52_I96_I1.6321.00
16_E19_K1.5741.00
50_R54_L1.5421.00
21_L157_L1.4901.00
82_H86_N1.4821.00
121_S124_E1.4801.00
90_K94_K1.4651.00
45_L49_E1.4281.00
122_R125_Y1.4161.00
104_C122_R1.4151.00
86_N90_K1.4131.00
9_K13_N1.3951.00
88_A92_A1.3891.00
168_K187_Y1.3771.00
122_R126_I1.3491.00
91_K95_N1.3481.00
99_A186_V1.3381.00
85_F88_A1.3271.00
82_H85_F1.3151.00
128_K131_K1.3081.00
101_S184_T1.3041.00
103_P121_S1.2911.00
42_S47_L1.2841.00
47_L68_C1.2601.00
67_W97_K1.2541.00
42_S46_S1.2531.00
4_V54_L1.2521.00
87_E91_K1.2401.00
159_K162_T1.2351.00
161_E165_K1.2131.00
4_V66_V1.2011.00
44_P47_L1.1951.00
14_Y112_H1.1901.00
110_L128_K1.1871.00
13_N16_E1.1831.00
145_Y148_N1.1721.00
72_R100_Y1.1591.00
92_A98_V1.1411.00
167_A187_Y1.1291.00
110_L125_Y1.1281.00
48_V88_A1.1271.00
4_V51_A1.1061.00
83_E87_E1.0941.00
89_I92_A1.0871.00
89_I98_V1.0771.00
107_L116_T1.0601.00
82_H88_A1.0491.00
97_K188_K1.0461.00
88_A91_K1.0461.00
84_D87_E1.0411.00
124_E127_K1.0381.00
100_Y185_T1.0311.00
37_I40_G1.0301.00
21_L153_Y1.0291.00
171_D183_S1.0261.00
48_V51_A1.0181.00
45_L87_E1.0161.00
173_E177_N1.0161.00
109_L160_L1.0101.00
87_E90_K1.0021.00
103_P122_R1.0011.00
123_D126_I0.9931.00
118_A128_K0.9821.00
104_C126_I0.9791.00
18_L190_V0.9781.00
48_V68_C0.9771.00
49_E91_K0.9671.00
18_L22_L0.9671.00
164_I168_K0.9611.00
51_A66_V0.9551.00
45_L84_D0.9481.00
41_G46_S0.9391.00
165_K169_K0.9391.00
103_P125_Y0.9371.00
72_R102_N0.9361.00
134_Y137_G0.9341.00
166_N169_K0.9321.00
100_Y183_S0.9281.00
149_S152_I0.9251.00
47_L70_F0.9211.00
69_V99_A0.9211.00
165_K168_K0.9201.00
90_K93_K0.9201.00
117_T173_E0.9161.00
110_L132_H0.9091.00
3_I69_V0.9051.00
48_V52_I0.9011.00
108_W163_A0.8961.00
152_I156_L0.8961.00
168_K172_E0.8921.00
86_N89_I0.8891.00
120_I124_E0.8871.00
167_A184_T0.8841.00
110_L116_T0.8841.00
44_P76_F0.8831.00
109_L129_L0.8751.00
164_I190_V0.8731.00
68_C96_I0.8691.00
47_L51_A0.8651.00
49_E52_I0.8631.00
70_F100_Y0.8591.00
116_T120_I0.8421.00
45_L91_K0.8401.00
111_L167_A0.8401.00
128_K132_H0.8381.00
81_Q84_D0.8331.00
160_L164_I0.8251.00
103_P107_L0.8211.00
48_V92_A0.8101.00
103_P181_N0.8071.00
34_V37_I0.7991.00
72_R85_F0.7971.00
109_L156_L0.7961.00
110_L114_E0.7961.00
153_Y157_L0.7951.00
85_F89_I0.7851.00
97_K192_E0.7851.00
174_H178_G0.7751.00
32_V35_I0.7751.00
184_T187_Y0.7741.00
187_Y191_E0.7721.00
115_D170_L0.7721.00
52_I91_K0.7711.00
16_E20_K0.7691.00
172_E175_E0.7681.00
176_E180_D0.7641.00
76_F79_E0.7631.00
4_V63_Y0.7561.00
46_S49_E0.7551.00
101_S186_V0.7531.00
188_K192_E0.7531.00
164_I187_Y0.7511.00
105_F186_V0.7481.00
4_V47_L0.7441.00
186_V190_V0.7421.00
151_D154_E0.7411.00
188_K191_E0.7411.00
17_G151_D0.7411.00
113_F159_K0.7381.00
174_H183_S0.7361.00
81_Q85_F0.7341.00
180_D183_S0.7331.00
40_G50_R0.7321.00
36_V39_G0.7291.00
120_I125_Y0.7231.00
175_E178_G0.7181.00
124_E128_K0.7161.00
101_S107_L0.7161.00
151_D155_I0.7151.00
85_F92_A0.7151.00
149_S153_Y0.7141.00
43_S84_D0.7101.00
174_H177_N0.7081.00
109_L152_I0.7081.00
10_T106_E0.7061.00
60_L63_Y0.7011.00
146_K150_K0.7011.00
32_V36_V0.6991.00
159_K166_N0.6981.00
126_I130_K0.6941.00
174_H179_P0.6921.00
70_F98_V0.6911.00
36_V40_G0.6901.00
82_H89_I0.6901.00
101_S187_Y0.6821.00
156_L160_L0.6741.00
186_V189_L0.6711.00
72_R82_H0.6681.00
69_V186_V0.6661.00
83_E86_N0.6661.00
15_F105_F0.6640.99
173_E176_E0.6620.99
172_E176_E0.6620.99
111_L184_T0.6520.99
153_Y160_L0.6410.99
111_L166_N0.6400.99
17_G20_K0.6380.99
3_I189_L0.6370.99
10_T109_L0.6300.99
25_I29_V0.6250.99
118_A121_S0.6240.99
56_K62_E0.6220.99
39_G42_S0.6210.99
17_G154_E0.6200.99
46_S50_R0.6170.99
160_L190_V0.6170.99
91_K94_K0.6120.99
17_G21_L0.6110.99
138_K141_K0.6100.99
113_F132_H0.6080.99
148_N153_Y0.6020.99
116_T128_K0.6020.99
22_L25_I0.6010.99
146_K149_S0.6010.99
38_K42_S0.6000.99
99_A185_T0.5990.99
36_V54_L0.5960.99
15_F189_L0.5910.99
84_D88_A0.5880.99
148_N151_D0.5880.99
18_L160_L0.5820.99
6_E39_G0.5820.99
89_I93_K0.5810.99
170_L182_P0.5810.99
85_F100_Y0.5800.99
51_A54_L0.5780.99
69_V189_L0.5750.99
82_H94_K0.5720.98
79_E85_F0.5720.98
149_S156_L0.5690.98
148_N152_I0.5690.98
33_V37_I0.5690.98
14_Y108_W0.5690.98
49_E53_E0.5680.98
67_W192_E0.5670.98
13_N17_G0.5630.98
5_C12_P0.5600.98
2_L66_V0.5590.98
154_E157_L0.5590.98
82_H92_A0.5580.98
67_W189_L0.5550.98
155_I158_D0.5540.98
114_E166_N0.5510.98
56_K61_E0.5420.98
51_A70_F0.5390.98
47_L50_R0.5390.98
111_L116_T0.5360.98
72_R75_D0.5360.98
14_Y163_A0.5360.98
147_K151_D0.5300.98
157_L160_L0.5300.98
169_K173_E0.5270.97
123_D127_K0.5230.97
149_S155_I0.5210.97
72_R77_P0.5210.97
108_W167_A0.5200.97
25_I28_N0.5180.97
108_W112_H0.5170.97
42_S50_R0.5120.97
6_E42_S0.5110.97
39_G44_P0.5100.97
134_Y145_Y0.5050.97
161_E164_I0.5040.97
75_D103_P0.5020.97
68_C88_A0.5020.97
19_K26_K0.5020.97
135_E138_K0.5000.97
51_A68_C0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p62A 2 0.8756 64.1 0.9 Contact Map
2au3A 1 0.7617 5.1 0.943 Contact Map
2fcjA 2 0.5907 5 0.943 Contact Map
1t6t1 2 0.4767 4.7 0.944 Contact Map
4kieA 1 0.2176 4.6 0.944 Contact Map
1czaN 1 0.2902 2.9 0.95 Contact Map
1gxgA 1 0.3264 2.7 0.95 Contact Map
2gecA 2 0.2435 2.6 0.95 Contact Map
4bwpA 2 0.4508 2.5 0.951 Contact Map
4o5pA 1 0.3679 2.5 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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