GREMLIN Database
zf-3CxxC - Zinc-binding domain
PFAM: PF13695 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 98 (96)
Sequences: 511 (375)
Seq/√Len: 38.3
META: 0.213

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_D91_L5.8541.00
66_C69_W3.8331.00
92_C95_C3.0451.00
3_F18_A2.7981.00
6_F17_S2.7041.00
23_L37_F2.4371.00
21_A36_V2.2841.00
41_C44_C2.2691.00
8_C11_C2.1950.99
21_A94_A2.0100.99
4_G20_V1.8570.98
63_L69_W1.8430.98
15_W39_Q1.7610.97
8_C41_C1.7410.97
38_G47_L1.7360.97
14_G19_K1.6770.96
8_C44_C1.6720.96
24_F94_A1.6500.96
24_F32_V1.5990.95
23_L49_N1.5660.94
42_K88_D1.5090.93
11_C41_C1.4900.92
58_L62_I1.4690.92
3_F55_N1.4370.91
73_P90_D1.4350.91
80_S97_Q1.4230.91
50_P86_P1.4140.90
35_R50_P1.3890.90
32_V58_L1.3110.87
29_G45_N1.2650.85
8_C15_W1.2620.84
32_V94_A1.2590.84
58_L94_A1.2210.82
85_G88_D1.2200.82
4_G33_N1.2140.82
23_L35_R1.1870.81
10_S78_V1.1740.80
3_F16_S1.1490.78
31_Q70_A1.1390.78
26_M38_G1.1240.77
26_M31_Q1.0830.74
20_V37_F1.0690.73
58_L66_C1.0080.69
73_P76_R1.0040.68
80_S83_S0.9820.66
13_R88_D0.9770.66
5_R55_N0.9730.66
13_R42_K0.9530.64
58_L67_Y0.9350.63
11_C44_C0.9080.60
5_R19_K0.8970.59
58_L69_W0.8840.58
2_A38_G0.8700.57
64_Y68_K0.8670.57
63_L66_C0.8580.56
20_V25_H0.8480.55
48_E57_N0.8270.53
68_K74_V0.8210.53
56_E60_E0.8200.53
62_I66_C0.8120.52
3_F52_F0.8050.51
50_P59_V0.8020.51
33_N65_R0.8000.51
10_S54_E0.7950.50
60_E68_K0.7630.47
42_K77_P0.7620.47
43_K47_L0.7590.47
18_A42_K0.7560.47
84_K90_D0.7530.47
10_S82_K0.7490.46
7_Q80_S0.7430.46
16_S55_N0.7420.46
81_D84_K0.7380.45
27_Y31_Q0.7230.44
5_R57_N0.7200.44
64_Y69_W0.7180.43
78_V81_D0.7160.43
11_C15_W0.7120.43
54_E83_S0.7090.43
13_R97_Q0.6960.42
54_E76_R0.6950.41
26_M50_P0.6870.41
7_Q73_P0.6820.40
67_Y72_V0.6810.40
45_N51_E0.6810.40
71_G75_E0.6780.40
10_S81_D0.6770.40
65_R93_E0.6760.40
38_G96_K0.6740.40
40_R61_R0.6730.40
7_Q78_V0.6650.39
12_S42_K0.6600.38
18_A34_M0.6580.38
38_G49_N0.6520.38
30_G67_Y0.6480.37
43_K80_S0.6480.37
73_P83_S0.6400.37
35_R52_F0.6400.37
4_G25_H0.6380.37
61_R66_C0.6380.37
4_G21_A0.6370.37
72_V77_P0.6350.36
82_K90_D0.6280.36
46_Q54_E0.6150.35
25_H93_E0.6150.35
29_G76_R0.6130.35
17_S36_V0.6110.34
22_I47_L0.6080.34
59_V63_L0.6080.34
12_S96_K0.6000.34
23_L38_G0.6000.34
59_V91_L0.5980.33
47_L54_E0.5910.33
16_S91_L0.5910.33
27_Y68_K0.5830.32
87_H91_L0.5810.32
16_S47_L0.5740.31
45_N83_S0.5740.31
16_S43_K0.5730.31
45_N54_E0.5690.31
40_R96_K0.5680.31
10_S74_V0.5660.31
36_V86_P0.5620.31
24_F66_C0.5570.30
57_N65_R0.5460.29
5_R30_G0.5410.29
20_V94_A0.5400.29
24_F62_I0.5400.29
38_G91_L0.5390.29
29_G89_S0.5340.28
14_G49_N0.5330.28
14_G59_V0.5310.28
9_S85_G0.5310.28
28_S81_D0.5240.28
10_S70_A0.5190.27
74_V81_D0.5180.27
3_F12_S0.5170.27
13_R43_K0.5160.27
87_H92_C0.5140.27
26_M37_F0.5130.27
34_M93_E0.5090.27
40_R94_A0.5060.26
28_S51_E0.5010.26
10_S16_S0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pofA 3 0.8163 32.4 0.875 Contact Map
2k2dA 1 0.4796 28.6 0.878 Contact Map
3ja82 1 0.8367 28.3 0.878 Contact Map
1ltlA 4 0.8061 27.6 0.879 Contact Map
4me3A 1 0.7959 17.4 0.89 Contact Map
2kdxA 1 0.5204 17 0.89 Contact Map
1qypA 1 0.1939 16.4 0.891 Contact Map
3ja86 1 0.8163 16.1 0.891 Contact Map
3ja87 1 0.8469 15.9 0.891 Contact Map
5aunA 1 0.6837 13.1 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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