GREMLIN Database
DUF4153 - Domain of unknown function (DUF4153)
PFAM: PF13687 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 216 (213)
Sequences: 3992 (3348)
Seq/√Len: 229.4
META: 0.839

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_N186_S3.6251.00
144_G148_S3.1731.00
147_I160_L2.7961.00
152_L204_I2.6801.00
145_L149_Q2.6061.00
152_L160_L2.5901.00
24_F27_D2.3601.00
140_F163_G2.3541.00
143_I159_V2.3141.00
82_I86_L2.2971.00
147_I152_L2.2961.00
11_L15_A2.2241.00
154_E205_S2.2011.00
30_I34_G2.0761.00
97_Y101_A2.0731.00
29_F33_A1.9851.00
165_W186_S1.8931.00
110_Y113_V1.8691.00
60_I65_I1.8691.00
83_K87_T1.8631.00
119_R123_L1.8601.00
43_A46_P1.8551.00
106_L111_N1.8171.00
3_A6_F1.8101.00
14_D25_Y1.7281.00
197_G200_D1.7241.00
92_K95_V1.7141.00
119_R122_R1.6971.00
157_Y161_L1.6851.00
31_F34_G1.6731.00
200_D203_R1.6551.00
36_F40_F1.6501.00
106_L109_L1.6501.00
146_R156_R1.6271.00
77_L80_Y1.6031.00
123_L126_R1.5871.00
103_I106_L1.5761.00
176_R180_R1.5711.00
206_V210_L1.5671.00
137_V141_Y1.5401.00
203_R207_R1.5401.00
35_L39_A1.5261.00
12_A17_F1.5111.00
182_N185_I1.4821.00
169_Y173_Y1.4501.00
98_L101_A1.4331.00
176_R179_K1.4331.00
2_F6_F1.4331.00
146_R150_Y1.4331.00
133_L136_L1.4301.00
89_L92_K1.4061.00
130_L174_L1.4031.00
87_T91_P1.3991.00
178_R181_W1.3891.00
11_L14_D1.3821.00
99_V102_F1.3731.00
161_L194_S1.3681.00
170_A173_Y1.3671.00
41_F44_L1.3651.00
107_L111_N1.3601.00
132_L136_L1.3421.00
77_L85_L1.3341.00
157_Y204_I1.3191.00
143_I160_L1.3191.00
111_N114_Y1.3181.00
32_I35_L1.3151.00
141_Y145_L1.3091.00
84_I91_P1.2991.00
164_L168_G1.2991.00
17_F79_A1.2971.00
23_D27_D1.2971.00
67_L71_L1.2891.00
95_V99_V1.2781.00
103_I107_L1.2621.00
176_R181_W1.2591.00
59_K63_Q1.2581.00
139_A163_G1.2571.00
78_Y81_L1.2541.00
52_I55_P1.2541.00
71_L75_L1.2531.00
177_K181_W1.2501.00
77_L84_I1.2481.00
140_F167_L1.2391.00
150_Y156_R1.2361.00
32_I36_F1.1981.00
51_E55_P1.1961.00
158_Y201_A1.1851.00
106_L113_V1.1831.00
13_I17_F1.1651.00
168_G172_Y1.1591.00
25_Y29_F1.1551.00
140_F160_L1.1531.00
24_F28_L1.1481.00
74_L102_F1.1441.00
80_Y84_I1.1431.00
36_F46_P1.1381.00
153_T156_R1.1341.00
127_W130_L1.1331.00
78_Y83_K1.1321.00
76_I80_Y1.1221.00
18_V26_A1.1221.00
205_S208_S1.1101.00
8_L11_L1.1041.00
125_A128_F1.1041.00
145_L148_S1.1011.00
81_L138_L1.0891.00
77_L83_K1.0851.00
201_A205_S1.0801.00
204_I207_R1.0661.00
210_L214_E1.0601.00
165_W169_Y1.0581.00
83_K86_L1.0571.00
171_L175_F1.0551.00
167_L170_A1.0531.00
208_S212_R1.0431.00
60_I64_Y1.0421.00
85_L88_W1.0391.00
98_L102_F1.0221.00
41_F46_P1.0151.00
90_W141_Y1.0141.00
74_L78_Y1.0011.00
73_Y77_L1.0011.00
196_F200_D0.9931.00
9_A76_I0.9731.00
36_F41_F0.9731.00
34_G39_A0.9731.00
143_I163_G0.9731.00
194_S197_G0.9691.00
183_I186_S0.9671.00
78_Y134_P0.9581.00
80_Y83_K0.9541.00
53_E57_R0.9531.00
207_R211_A0.9511.00
207_R210_L0.9511.00
23_D26_A0.9481.00
184_P197_G0.9401.00
86_L91_P0.9351.00
10_L28_L0.9321.00
106_L114_Y0.9311.00
97_Y100_L0.9251.00
59_K62_L0.9181.00
13_I29_F0.9161.00
50_A53_E0.9141.00
151_G208_S0.9091.00
209_Q213_L0.9070.99
203_R206_V0.9020.99
15_A94_W0.9000.99
184_P187_L0.8910.99
92_K96_S0.8870.99
129_P132_L0.8850.99
80_Y91_P0.8760.99
31_F36_F0.8750.99
22_I26_A0.8710.99
157_Y201_A0.8690.99
177_K180_R0.8640.99
26_A29_F0.8590.99
114_Y117_G0.8550.99
61_L65_I0.8520.99
99_V139_A0.8510.99
78_Y82_I0.8450.99
88_W91_P0.8340.99
199_L204_I0.8330.99
35_L42_L0.8300.99
27_D31_F0.8270.99
42_L45_I0.8260.99
184_P198_P0.8250.99
120_W124_F0.8230.99
85_L91_P0.8220.99
133_L170_A0.8170.99
125_A129_P0.8140.99
105_V111_N0.8130.99
195_S200_D0.8110.99
209_Q212_R0.8100.99
22_I25_Y0.8060.99
73_Y98_L0.8010.99
49_E53_E0.7990.99
13_I18_V0.7970.99
120_W123_L0.7940.99
96_S99_V0.7940.99
104_A109_L0.7920.99
79_A82_I0.7910.99
187_L198_P0.7890.99
37_A46_P0.7880.99
34_G37_A0.7880.99
182_N187_L0.7870.99
99_V135_L0.7840.99
158_Y161_L0.7830.99
51_E54_Y0.7750.98
21_G25_Y0.7720.98
41_F45_I0.7650.98
38_P41_F0.7640.98
10_L13_I0.7570.98
7_W11_L0.7570.98
122_R125_A0.7480.98
106_L128_F0.7460.98
43_A47_E0.7450.98
103_I111_N0.7440.98
106_L112_A0.7440.98
107_L114_Y0.7410.98
182_N190_L0.7380.98
162_L166_L0.7310.98
133_L137_V0.7280.98
103_I114_Y0.7190.97
35_L40_F0.7160.97
124_F128_F0.7130.97
172_Y176_R0.7130.97
202_F206_V0.7010.97
96_S159_V0.7000.97
3_A7_W0.6980.97
18_V23_D0.6970.97
49_E52_I0.6970.97
72_I107_L0.6940.97
111_N117_G0.6920.97
40_F43_A0.6890.97
155_N159_V0.6880.97
158_Y162_L0.6850.97
93_G98_L0.6810.96
95_V142_A0.6780.96
47_E51_E0.6770.96
158_Y194_S0.6750.96
20_I24_F0.6660.96
81_L85_L0.6650.96
210_L213_L0.6640.96
170_A174_L0.6610.96
14_D18_V0.6580.96
79_A83_K0.6570.96
78_Y84_I0.6560.96
34_G41_F0.6560.96
93_G96_S0.6530.95
85_L89_L0.6520.95
97_Y102_F0.6520.95
111_N115_Q0.6520.95
14_D19_L0.6490.95
157_Y200_D0.6480.95
4_G8_L0.6480.95
32_I41_F0.6480.95
34_G38_P0.6430.95
61_L64_Y0.6420.95
49_E55_P0.6390.95
110_Y114_Y0.6370.95
49_E54_Y0.6350.95
90_W93_G0.6350.95
84_I88_W0.6330.95
60_I63_Q0.6260.94
18_V21_G0.6220.94
113_V116_D0.6200.94
34_G42_L0.6170.94
95_V98_L0.6160.94
169_Y172_Y0.6160.94
186_S189_L0.6110.94
47_E50_A0.6070.93
205_S209_Q0.6050.93
6_F29_F0.6050.93
84_I87_T0.6020.93
32_I37_A0.6020.93
136_L170_A0.6010.93
33_A36_F0.5990.93
37_A42_L0.5980.93
146_R149_Q0.5980.93
81_L84_I0.5970.93
12_A15_A0.5950.93
109_L113_V0.5950.93
161_L165_W0.5920.92
20_I25_Y0.5880.92
55_P58_L0.5850.92
30_I33_A0.5840.92
122_R126_R0.5830.92
31_F35_L0.5820.92
102_F131_L0.5800.92
144_G160_L0.5790.92
8_L12_A0.5780.92
150_Y153_T0.5730.91
96_S139_A0.5720.91
199_L203_R0.5720.91
32_I46_P0.5710.91
189_L193_L0.5710.91
4_G11_L0.5670.91
185_I188_A0.5650.91
67_L70_V0.5630.91
185_I189_L0.5620.90
31_F46_P0.5600.90
165_W187_L0.5540.90
142_A146_R0.5540.90
182_N197_G0.5490.89
122_R127_W0.5470.89
124_F127_W0.5470.89
27_D30_I0.5450.89
95_V102_F0.5410.89
9_A12_A0.5380.88
82_I85_L0.5370.88
10_L24_F0.5370.88
33_A38_P0.5340.88
190_L194_S0.5330.88
103_I113_V0.5310.88
84_I138_L0.5310.88
96_S102_F0.5300.88
78_Y85_L0.5300.88
13_I25_Y0.5300.88
80_Y85_L0.5270.87
15_A18_V0.5240.87
10_L20_I0.5190.87
37_A40_F0.5180.87
59_K64_Y0.5150.86
94_W98_L0.5150.86
38_P45_I0.5150.86
136_L167_L0.5140.86
2_F29_F0.5120.86
38_P42_L0.5100.86
81_L90_W0.5090.86
25_Y28_L0.5070.85
188_A191_A0.5070.85
90_W96_S0.5060.85
101_A106_L0.5050.85
33_A45_I0.5040.85
32_I38_P0.5040.85
19_L22_I0.5030.85
211_A214_E0.5020.85
103_I136_L0.5020.85
36_F39_A0.5010.85
10_L14_D0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfF 1 0.4074 7 0.94 Contact Map
2a65A 2 0.5648 2.7 0.951 Contact Map
2i68A 2 0.338 2.5 0.952 Contact Map
4hfiA 3 0.6065 2.2 0.953 Contact Map
2mgyA 1 0.7037 2.1 0.954 Contact Map
4hyjA 2 0.7824 2.1 0.954 Contact Map
2yevC 1 0.1806 1.7 0.956 Contact Map
2jnaA 2 0.1667 1.5 0.957 Contact Map
2mofA 1 0.1944 1.5 0.957 Contact Map
2cp8A 1 0.088 1.3 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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