GREMLIN Database
PilX - Type IV pilus assembly protein PilX C-term
PFAM: PF13681 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (100)
Sequences: 1959 (1678)
Seq/√Len: 167.8
META: 0.866

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_T101_Q4.2631.00
88_R97_Q3.9061.00
60_E84_R3.8611.00
36_G39_T3.1531.00
48_G51_V3.0501.00
93_S96_T2.4481.00
33_V37_T2.1401.00
82_V105_R2.1091.00
53_A94_P2.0281.00
61_Y81_Y1.9591.00
88_R99_V1.9091.00
62_L103_T1.7201.00
35_Y39_T1.7071.00
34_A37_T1.6911.00
27_P30_A1.6721.00
85_I102_S1.6611.00
60_E86_T1.6291.00
10_T13_P1.6271.00
62_L84_R1.6011.00
35_Y38_F1.5821.00
58_I86_T1.5761.00
33_V38_F1.5621.00
24_F28_A1.4711.00
53_A90_F1.4631.00
91_G96_T1.4551.00
7_P12_P1.4021.00
33_V36_G1.3811.00
84_R101_Q1.3531.00
73_L76_A1.3381.00
9_A14_P1.3351.00
59_I101_Q1.3021.00
34_A38_F1.2991.00
90_F97_Q1.2901.00
32_T35_Y1.2791.00
32_T37_T1.2591.00
82_V103_T1.2291.00
98_V101_Q1.2221.00
46_G51_V1.2051.00
11_G14_P1.1711.00
25_T28_A1.1661.00
39_T43_F1.1571.00
32_T36_G1.1421.00
60_E101_Q1.0911.00
64_D79_P1.0831.00
3_G60_E1.0550.99
18_A58_I1.0500.99
24_F27_P1.0250.99
45_A48_G1.0150.99
92_G96_T1.0120.99
64_D81_Y1.0070.99
58_I85_I1.0050.99
6_A11_G0.9550.99
51_V54_Q0.9110.98
22_V25_T0.9080.98
10_T14_P0.8900.98
52_A55_P0.8870.98
38_F41_A0.8770.98
43_F54_Q0.8750.98
55_P91_G0.8730.98
3_G7_P0.8710.98
6_A9_A0.8650.98
39_T42_A0.8470.97
20_T25_T0.8400.97
33_V39_T0.8360.97
63_G81_Y0.8300.97
55_P58_I0.8250.97
70_S79_P0.8170.97
56_R89_G0.8160.97
67_D72_G0.8160.97
21_T26_D0.8110.97
8_A11_G0.8060.97
8_A13_P0.8040.97
21_T27_P0.7940.96
58_I99_V0.7880.96
62_L79_P0.7760.96
9_A12_P0.7620.95
43_F51_V0.7590.95
19_W99_V0.7570.95
61_Y83_Y0.7570.95
74_A78_T0.7380.94
99_V103_T0.7360.94
58_I101_Q0.7350.94
52_A94_P0.7340.94
25_T29_T0.7270.94
35_Y43_F0.7260.94
41_A92_G0.7250.94
66_P72_G0.7140.93
66_P79_P0.7100.93
25_T99_V0.6960.93
44_G48_G0.6910.92
58_I89_G0.6760.91
90_F94_P0.6750.91
46_G49_P0.6650.91
68_G83_Y0.6630.91
9_A13_P0.6620.91
74_A77_S0.6550.90
87_A100_L0.6540.90
3_G57_Y0.6520.90
8_A14_P0.6500.90
7_P10_T0.6460.89
56_R91_G0.6370.89
52_A90_F0.6310.88
78_T87_A0.6310.88
18_A26_D0.6300.88
68_G80_R0.6290.88
41_A50_G0.6260.88
7_P11_G0.6220.88
5_C61_Y0.6160.87
34_A40_G0.6110.87
33_V40_G0.6050.86
26_D29_T0.6040.86
21_T24_F0.6000.86
69_G80_R0.5950.85
80_R83_Y0.5930.85
61_Y102_S0.5780.84
7_P62_L0.5770.83
63_G98_V0.5770.83
81_Y104_Y0.5750.83
11_G87_A0.5740.83
57_Y88_R0.5740.83
68_G71_A0.5690.83
32_T104_Y0.5640.82
63_G89_G0.5630.82
3_G14_P0.5580.81
41_A44_G0.5570.81
89_G93_S0.5570.81
20_T23_D0.5530.81
56_R83_Y0.5470.80
45_A51_V0.5370.79
94_P97_Q0.5370.79
56_R88_R0.5370.79
68_G104_Y0.5340.79
91_G94_P0.5330.78
19_W22_V0.5320.78
83_Y105_R0.5320.78
8_A12_P0.5300.78
19_W102_S0.5280.78
65_V71_A0.5270.78
8_A83_Y0.5250.77
43_F46_G0.5210.77
88_R98_V0.5140.76
64_D93_S0.5120.76
22_V104_Y0.5120.76
90_F99_V0.5110.75
20_T24_F0.5100.75
71_A77_S0.5070.75
79_P82_V0.5060.75
74_A79_P0.5060.75
84_R98_V0.5000.74
55_P89_G0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s6sA 1 0.1226 3.4 0.909 Contact Map
2h57A 1 0.2358 2.2 0.917 Contact Map
2a5jA 1 0.3302 1.7 0.922 Contact Map
4lpvA 5 0.7642 1.4 0.926 Contact Map
2l53B 1 0.1698 1.4 0.927 Contact Map
3lluA 3 0.2264 1.3 0.927 Contact Map
4g97A 1 0.3585 1.3 0.927 Contact Map
4sbvA 8 0.6509 1.2 0.928 Contact Map
2h17A 1 0.2264 1.2 0.929 Contact Map
4c2lA 1 0.2358 1.2 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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