GREMLIN Database
MotB_plug - Membrane MotB of proton-channel complex MotA/MotB
PFAM: PF13677 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (53)
Sequences: 20679 (10770)
Seq/√Len: 1479.3
META: 0.908

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_Y26_V2.9771.00
30_M34_V2.4591.00
22_Y27_T2.4451.00
19_L23_A2.2441.00
43_D46_K2.2231.00
21_T25_F1.8871.00
44_E48_K1.5401.00
42_V47_F1.5281.00
51_A55_R1.4921.00
20_V23_A1.4611.00
15_G20_V1.3851.00
17_R20_V1.3431.00
41_S44_E1.3001.00
45_E48_K1.2861.00
49_A52_E1.2841.00
23_A27_T1.2691.00
14_H17_R1.2691.00
52_E56_D1.2601.00
10_E13_H1.2501.00
12_G15_G1.2491.00
42_V46_K1.2041.00
32_F36_L1.1791.00
47_F51_A1.1731.00
54_F57_A1.1721.00
31_A35_V1.1651.00
6_K9_E1.1401.00
48_K52_E1.1311.00
46_K49_A1.1011.00
45_E49_A1.0951.00
28_L31_A1.0801.00
39_M42_V1.0041.00
32_F35_V0.9901.00
28_L34_V0.9771.00
5_K8_E0.9631.00
17_R21_T0.9361.00
44_E47_F0.9311.00
21_T24_D0.9181.00
21_T28_L0.9151.00
18_W24_D0.9021.00
35_V39_M0.8791.00
4_K8_E0.8581.00
24_D27_T0.8301.00
5_K10_E0.8011.00
34_V38_S0.7781.00
8_E12_G0.7451.00
39_M50_L0.7401.00
18_W21_T0.7391.00
50_L54_F0.7321.00
26_V30_M0.7291.00
19_L28_L0.7161.00
39_M47_F0.6981.00
38_S42_V0.6941.00
51_A56_D0.6791.00
16_E19_L0.6791.00
20_V25_F0.6761.00
9_E12_G0.6731.00
50_L53_S0.6611.00
5_K9_E0.6601.00
12_G16_E0.6601.00
40_S43_D0.6531.00
37_Y47_F0.6461.00
34_V37_Y0.6411.00
11_E16_E0.6391.00
4_K10_E0.6361.00
13_H16_E0.6301.00
30_M37_Y0.6221.00
34_V41_S0.6121.00
8_E11_E0.6041.00
41_S45_E0.5981.00
21_T35_V0.5951.00
27_T31_A0.5911.00
6_K10_E0.5761.00
13_H17_R0.5751.00
48_K51_A0.5621.00
10_E14_H0.5311.00
40_S46_K0.5281.00
18_W50_L0.5051.00
17_R25_F0.5031.00
25_F57_A0.5011.00
37_Y42_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a16A 2 1 5.1 0.867 Contact Map
4nqiA 2 0.069 4 0.873 Contact Map
1dbgA 1 0.1897 4 0.873 Contact Map
3hisA 1 0.4655 3.6 0.877 Contact Map
3owqA 1 0.0517 3.4 0.878 Contact Map
4n78D 1 0.1207 3.4 0.878 Contact Map
3h3hA 2 0.3276 2.7 0.885 Contact Map
4av3A 2 0.7586 2.7 0.885 Contact Map
1vkyA 2 0.4828 2.6 0.885 Contact Map
1wdiA 1 0.4828 2.5 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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